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Wasting disease

MedGen UID:
22696
•Concept ID:
C0043046
•
Disease or Syndrome
Synonyms: Wasting Disease; Wasting Diseases; Wasting Syndrome; Wasting Syndromes
SNOMED CT: Wasting disease (288517002)

Definition

Pathologic loss of more than 10% of body weight concurrent with 30 or more days of either diarrhea or weakness and fever. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVWasting disease

Professional guidelines

PubMed

Nutrition Management for Chronic Kidney Disease: Differences and Special Needs for Children and Adults.
Mak RH, Iyengar A, Wang AY
Semin Nephrol 2023 Jul;43(4):151441. Epub 2023 Nov 18 doi: 10.1016/j.semnephrol.2023.151441. PMID: 37981474
The Effect of Cannabis-Based Medicine in the Treatment of Cachexia: A Systematic Review and Meta-Analysis.
Hammond S, Erridge S, Mangal N, Pacchetti B, Sodergren MH
Cannabis Cannabinoid Res 2021 Dec;6(6):474-487. Epub 2021 Oct 18 doi: 10.1089/can.2021.0048. PMID: 34664988Free PMC Article
A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease.
Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H, Guarnieri G, Ikizler TA, Kaysen G, Lindholm B, Massy Z, Mitch W, Pineda E, Stenvinkel P, Treviño-Becerra A, Wanner C
Kidney Int 2008 Feb;73(4):391-8. Epub 2007 Dec 19 doi: 10.1038/sj.ki.5002585. PMID: 18094682

Recent clinical studies

Etiology

Novel dietary strategies to manage sarcopenia.
Cailleaux PE, Déchelotte P, Coëffier M
Curr Opin Clin Nutr Metab Care 2024 May 1;27(3):234-243. Epub 2024 Feb 23 doi: 10.1097/MCO.0000000000001023. PMID: 38391396
Chronic wasting disease: Emerging prions and their potential risk.
Hannaoui S, Schatzl HM, Gilch S
PLoS Pathog 2017 Nov;13(11):e1006619. Epub 2017 Nov 2 doi: 10.1371/journal.ppat.1006619. PMID: 29095921Free PMC Article
Prion Diseases.
Whitechurch BC, Welton JM, Collins SJ, Lawson VA
Adv Neurobiol 2017;15:335-364. doi: 10.1007/978-3-319-57193-5_13. PMID: 28674988
Wasting disease in African children: the challenges ahead.
Heikens GT, Manary M
Malawi Med J 2009 Sep;21(3):101-5. doi: 10.4314/mmj.v21i3.45628. PMID: 20345017Free PMC Article
Prion diseases.
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932

Diagnosis

Duchenne muscular dystrophy.
Duan D, Goemans N, Takeda S, Mercuri E, Aartsma-Rus A
Nat Rev Dis Primers 2021 Feb 18;7(1):13. doi: 10.1038/s41572-021-00248-3. PMID: 33602943Free PMC Article
Progress in muscular dystrophy research with special emphasis on gene therapy.
Sugita H, Takeda S
Proc Jpn Acad Ser B Phys Biol Sci 2010;86(7):748-56. doi: 10.2183/pjab.86.748. PMID: 20689232Free PMC Article
Infections of the nervous system.
Gendelman HE, Persidsky Y
Lancet Neurol 2005 Jan;4(1):12-3. doi: 10.1016/S1474-4422(04)00951-2. PMID: 15620853Free PMC Article
Epithelial sodium channel, salt intake, and hypertension.
Hummler E
Curr Hypertens Rep 2003 Feb;5(1):11-8. doi: 10.1007/s11906-003-0005-1. PMID: 12530930
Muscle wasting disease of endocrine origin.
Fitch CD
Med Clin North Am 1968 Mar;52(2):243-52. PMID: 4872207

Therapy

Gene Therapy for Duchenne Muscular Dystrophy.
Elangkovan N, Dickson G
J Neuromuscul Dis 2021;8(s2):S303-S316. doi: 10.3233/JND-210678. PMID: 34511510Free PMC Article
Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy.
Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M
Sci Rep 2017 May 30;7:46126. doi: 10.1038/srep46126. PMID: 28555643Free PMC Article
Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.
Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM
Proc Natl Acad Sci U S A 2015 Dec 8;112(49):E6780-9. Epub 2015 Nov 23 doi: 10.1073/pnas.1512968112. PMID: 26598680Free PMC Article
Progress in muscular dystrophy research with special emphasis on gene therapy.
Sugita H, Takeda S
Proc Jpn Acad Ser B Phys Biol Sci 2010;86(7):748-56. doi: 10.2183/pjab.86.748. PMID: 20689232Free PMC Article
Epithelial sodium channel, salt intake, and hypertension.
Hummler E
Curr Hypertens Rep 2003 Feb;5(1):11-8. doi: 10.1007/s11906-003-0005-1. PMID: 12530930

Prognosis

Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.
Rodgers BD, Ward CW
Endocr Rev 2022 Mar 9;43(2):329-365. doi: 10.1210/endrev/bnab030. PMID: 34520530Free PMC Article
Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia.
Haider S, Islam B, D'Atri V, Sgobba M, Poojari C, Sun L, Yuen T, Zaidi M, New MI
Proc Natl Acad Sci U S A 2013 Feb 12;110(7):2605-10. Epub 2013 Jan 28 doi: 10.1073/pnas.1221133110. PMID: 23359706Free PMC Article
Prion diseases.
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932
Disseminated histoplasmosis in patients infected with human immunodeficiency virus.
Sarosi GA, Johnson PC
Clin Infect Dis 1992 Mar;14 Suppl 1:S60-7. doi: 10.1093/clinids/14.supplement_1.s60. PMID: 1562697
Muscle wasting disease of endocrine origin.
Fitch CD
Med Clin North Am 1968 Mar;52(2):243-52. PMID: 4872207

Clinical prediction guides

CRISPR applications for Duchenne muscular dystrophy: From animal models to potential therapies.
Chey YCJ, Arudkumar J, Aartsma-Rus A, Adikusuma F, Thomas PQ
WIREs Mech Dis 2023 Jan;15(1):e1580. Epub 2022 Jul 31 doi: 10.1002/wsbm.1580. PMID: 35909075Free PMC Article
Bias correction of bounded location error in binary data.
Walker NB, Hefley TJ, Walsh DP
Biometrics 2020 Jun;76(2):530-539. Epub 2019 Nov 20 doi: 10.1111/biom.13152. PMID: 31517389
Energy metabolism in cachexia.
Rohm M, Zeigerer A, Machado J, Herzig S
EMBO Rep 2019 Apr;20(4) Epub 2019 Mar 19 doi: 10.15252/embr.201847258. PMID: 30890538Free PMC Article
Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia.
Haider S, Islam B, D'Atri V, Sgobba M, Poojari C, Sun L, Yuen T, Zaidi M, New MI
Proc Natl Acad Sci U S A 2013 Feb 12;110(7):2605-10. Epub 2013 Jan 28 doi: 10.1073/pnas.1221133110. PMID: 23359706Free PMC Article
Prion diseases.
Johnson RT
Lancet Neurol 2005 Oct;4(10):635-42. doi: 10.1016/S1474-4422(05)70192-7. PMID: 16168932

Recent systematic reviews

Effects of Exercise Programs in older adults with Muscle Wasting: A Systematic Review and Meta-analysis: Effects of Exercise Programs in Muscle Wasting.
Ni HJ, Hsu TF, Chen LK, Chou HL, Tung HH, Chow LH, Chen YC
Arch Gerontol Geriatr 2022 Mar-Apr;99:104605. Epub 2021 Dec 2 doi: 10.1016/j.archger.2021.104605. PMID: 34922244
Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review.
Anker MS, Holcomb R, Muscaritoli M, von Haehling S, Haverkamp W, Jatoi A, Morley JE, Strasser F, Landmesser U, Coats AJS, Anker SD
J Cachexia Sarcopenia Muscle 2019 Feb;10(1):22-34. doi: 10.1002/jcsm.12402. PMID: 30920776Free PMC Article
Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review.
Waddell L, Greig J, Mascarenhas M, Otten A, Corrin T, Hierlihy K
Transbound Emerg Dis 2018 Feb;65(1):37-49. Epub 2017 Jan 30 doi: 10.1111/tbed.12612. PMID: 28139079
Pellagra may be a rare secondary complication of anorexia nervosa: a systematic review of the literature.
Prousky JE
Altern Med Rev 2003 May;8(2):180-5. PMID: 12777163

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