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Adult yolk sac tumor

MedGen UID:
231046
•Concept ID:
C1332221
•
Neoplastic Process
Synonyms: Adult Endodermal Sinus Neoplasm; adult endodermal sinus neoplasm; Adult Endodermal Sinus Tumor; adult endodermal sinus tumor; adult endodermal sinus tumour; Adult Yolk Sac Neoplasm; adult yolk Sac neoplasm; Adult Yolk Sac Tumor; adult yolk sac tumor; adult yolk Sac tumor; adult yolk Sac tumour; yolk sac tumor of adults; yolk sac tumour of adults
 
Monarch Initiative: MONDO:0003404

Definition

A yolk sac tumor that occurs in an adult. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult yolk sac tumor

Professional guidelines

PubMed

Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
CT imaging of ovarian yolk sac tumor with emphasis on differential diagnosis.
Li YK, Zheng Y, Lin JB, Xu GX, Cai AQ, Zhou XG, Zhang GJ
Sci Rep 2015 Jun 15;5:11000. doi: 10.1038/srep11000. PMID: 26074455Free PMC Article
Evaluation and management of pediatric solid ovarian tumors.
Lazar EL, Stolar CJ
Semin Pediatr Surg 1998 Feb;7(1):29-34. doi: 10.1016/s1055-8586(98)70003-4. PMID: 9498265

Recent clinical studies

Etiology

Usefulness of pelvic lymphadenectomy in staging of ovarian dysgerminoma.
Zeferino-Toquero M, Rivas-Corchado LM, Maytorena-Córdova G, Reyna-Amaya H, Bañuelos-Flores J
Cir Cir 2024;92(6):804-807. doi: 10.24875/CIRU.22000427. PMID: 39591572
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
To Transplant or Not to Transplant During the SARS-CoV-2 Pandemic? That Is the Question.
Marino D, Finotto S, Basso U, Galiano A, Bolshinsky M, Amato O, Marson P, Tison T, Colpo A, Zagonel V
Oncologist 2021 Feb;26(2):e336-e337. Epub 2020 Oct 23 doi: 10.1002/onco.13563. PMID: 33044758Free PMC Article
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976
Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary.
Motegi M, Takakura S, Takano H, Tanaka T, Ochiai K
Obstet Gynecol 2007 Feb;109(2 Pt2):537-40. doi: 10.1097/01.AOG.0000245450.62758.47. PMID: 17267887

Diagnosis

Malignant priapism and germ cell tumour.
Lam KO, Huang J
Lancet Oncol 2019 Apr;20(4):e224. doi: 10.1016/S1470-2045(19)30075-0. PMID: 30942183
Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature.
Furr JR, Mellis AM, Slobodov G
Urol Int 2015;95(2):240-2. Epub 2015 Apr 2 doi: 10.1159/000371660. PMID: 25871265
Ruptured testicular yolk sac tumor.
Zechlinski J, Sharafinski M, Sudakoff G
Ultrasound Q 2014 Sep;30(3):238-40. doi: 10.1097/RUQ.0000000000000088. PMID: 25148504
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976
Management of neutropenic colitis.
Vohra R, Prescott RJ, Banerjee SS, Wilkinson PM, Schofield PF
Surg Oncol 1992 Feb;1(1):11-5. doi: 10.1016/0960-7404(92)90051-l. PMID: 1341230

Therapy

Malignant priapism and germ cell tumour.
Lam KO, Huang J
Lancet Oncol 2019 Apr;20(4):e224. doi: 10.1016/S1470-2045(19)30075-0. PMID: 30942183
Primary Yolk Sac Tumor of the Prostate: A Case Report and Review of the Literature.
Furr JR, Mellis AM, Slobodov G
Urol Int 2015;95(2):240-2. Epub 2015 Apr 2 doi: 10.1159/000371660. PMID: 25871265
Primary yolk sac tumor of the endometrium: a case report and review of the literature.
Rossi R, Stacchiotti D, Bernardini MG, Calvieri G, Lo Voi R
Am J Obstet Gynecol 2011 Apr;204(4):e3-4. Epub 2011 Feb 23 doi: 10.1016/j.ajog.2010.12.014. PMID: 21345404
Pure yolk-sac tumor of the lung.
Basoglu A, Sengul AT, Buyukkarabacak YB, Yetim TD, Yildiz L
Asian Cardiovasc Thorac Ann 2008 Oct;16(5):410-1. doi: 10.1177/021849230801600514. PMID: 18812352
Germ cell tumours of the ovary.
Guillem V, Poveda A
Clin Transl Oncol 2007 Apr;9(4):237-43. doi: 10.1007/s12094-007-0045-0. PMID: 17462976

Prognosis

Alpha-Fetoprotein-Producing Esophageal Adenocarcinoma With Enteroblastic, Yolk Sac Tumor-Like, and Hepatoid Carcinoma Differentiation: A Rare Case and Literature Review.
Shore KT, Phelps KC, Balani J, Mitchell JM
Int J Surg Pathol 2023 Aug;31(5):884-889. Epub 2022 Dec 13 doi: 10.1177/10668969221142041. PMID: 36514283
Pediatric vulvar malignancies: rare but important to know.
Strickland AL, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):99-109. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.001. PMID: 32943238
Primary yolk sac tumor of endometrium: report of two cases and review of literature.
Qzler A, Dogan S, Mamedbeyli G, Rahatli S, Haberal AN, Dursun P, Ayhan A
J Exp Ther Oncol 2015;11(1):5-9. PMID: 26259383
Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary.
Motegi M, Takakura S, Takano H, Tanaka T, Ochiai K
Obstet Gynecol 2007 Feb;109(2 Pt2):537-40. doi: 10.1097/01.AOG.0000245450.62758.47. PMID: 17267887
Good fetal outcome of pregnancies with gynecologic cancer conditions: cases and literature review.
Ghaemmaghami F, Hasanzadeh M
Int J Gynecol Cancer 2006 Jan-Feb;16 Suppl 1:225-30. doi: 10.1111/j.1525-1438.2006.00510.x. PMID: 16515595

Clinical prediction guides

Dramatic response to local radiotherapy in a refractory metastatic mediastinal yolk sac tumor patient harboring a germline BRCA2 frameshift mutation: a case report.
Cheng X, Yu H, Li J, Han X, Meng E, Zhou H, Wang D, Niu B, Zhang X
Cancer Biol Ther 2022 Dec 31;23(1):393-400. doi: 10.1080/15384047.2022.2072635. PMID: 35576916Free PMC Article
How and where to expect endosalpingiosis intraoperatively.
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Yolk Sac Tumor of the Ovary: A Report of 150 Cases and Review of the Literature.
Young RH, Wong A, Stall JN
Am J Surg Pathol 2022 Mar 1;46(3):309-325. doi: 10.1097/PAS.0000000000001793. PMID: 34469331
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Adjuvant chemotherapy in a pregnant woman with endodermal sinus tumor of the ovary.
Motegi M, Takakura S, Takano H, Tanaka T, Ochiai K
Obstet Gynecol 2007 Feb;109(2 Pt2):537-40. doi: 10.1097/01.AOG.0000245450.62758.47. PMID: 17267887

Recent systematic reviews

Primary yolk sac tumor of the endometrium: a case report and review of the literatures.
Lu T, Qi L, Ma Y, Lu G, Zhang X, Liu P
Arch Gynecol Obstet 2019 Nov;300(5):1177-1187. Epub 2019 Sep 23 doi: 10.1007/s00404-019-05309-3. PMID: 31549219

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