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Appendix Mucinous Cystadenoma

MedGen UID:
231939
•Concept ID:
C1332518
•
Neoplastic Process
Synonyms: Colloid Appendiceal Cystadenoma; Colloid Cystadenoma of Appendix; Colloidal Cystadenoma of Appendix; Mucinous Appendiceal Cystadenoma; Mucinous Appendix Cystadenoma; Mucinous Cystadenoma of Appendix; Mucinous Cystadenoma of the Appendix

Definition

A cystically dilated epithelial neoplasm arising from the appendix. It is characterized by the presence of a cystic structure that is filled with mucus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix Mucinous Cystadenoma

Professional guidelines

PubMed

Appendiceal tumors in patients undergoing primary surgery for mucinous ovarian tumors in a tertiary hospital, in Southern Thailand.
Nanthamongkolkul K, Wattanapaisal P, Boonyapipat S, Suphasynth Y, Pichatechaiyoot A, Geater AF, Kayasut K, Peeyananjarassri K
Taiwan J Obstet Gynecol 2022 Jul;61(4):657-662. doi: 10.1016/j.tjog.2022.03.042. PMID: 35779917
Intraperitoneal hyperthermia in the management of pseudomyxoma peritonei.
Hsu KH, Chou CY, Chang YC
Hepatogastroenterology 2007 Jan-Feb;54(73):47-52. PMID: 17419229

Recent clinical studies

Etiology

Mucinous cystadenoma of the appendix: CT findings.
Zhou ML, Yan FH, Xu PJ, Zhang LJ, Li QH, Ji Y
Chin Med J (Engl) 2006 Aug 5;119(15):1300-3. PMID: 16919190
Colonoscopic diagnosis of mucocele of the appendix.
Zanati SA, Martin JA, Baker JP, Streutker CJ, Marcon NE
Gastrointest Endosc 2005 Sep;62(3):452-6. doi: 10.1016/j.gie.2005.04.018. PMID: 16111974
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Adenocarcinoma of the vermiform appendix: retrospective study and literature review.
Panton ON, Bell GA, Owen DA
Can J Surg 1983 May;26(3):276-9. PMID: 6303543
Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal "mucocele".
Higa E, Rosai J, Pizzimbono CA, Wise L
Cancer 1973 Dec;32(6):1525-41. doi: 10.1002/1097-0142(197312)32:6<1525::aid-cncr2820320632>3.0.co;2-c. PMID: 4757938

Diagnosis

Appendiceal mucocele - Case Report and Review of the Literature.
Asenov Y, Korukov B, Penkov N, Sedloev T, Tihtchev V, Hadzhiysca V, Damianov D
Chirurgia (Bucur) 2015 Nov-Dec;110(6):565-9. PMID: 26713834
The appropriate management of an appendiceal mucocele.
Lorenzon L, De Dominicis C, Virgilio E, Balducci G
BMJ Case Rep 2015 Mar 16;2015 doi: 10.1136/bcr-2014-209045. PMID: 25777488Free PMC Article
Mucinous cystadenoma of the appendix.
Iswariah H, Metcalfe M, Lituri D, Maddern GJ
ANZ J Surg 2004 Oct;74(10):918-9. doi: 10.1111/j.1445-1433.2004.03180.x. PMID: 15456452
Appendiceal mucocele.
Watanabe T, Yoshikawa I, Kihara Y, Kume K, Otsuki M
Gastrointest Endosc 2003 Dec;58(6):909-10. doi: 10.1016/s0016-5107(03)02283-1. PMID: 14652562
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765

Therapy

Unexpected findings in the routine histopathological examinations of appendectomy specimens A retrospective analysis of 1,970 patients.
Dincel O, Goksu M, Turk BA, Pehlivanoglu B, Isler S
Ann Ital Chir 2017;88:519-525. PMID: 29339597
Appendiceal carcinoid and mucinous cystadenoma in renal transplant recipients: case reports.
Basic-Jukic N, Furic-Cunko V, Coric M, Bubic-Filipi LJ, Kastelan Z, Pasini J, Kes P
Transplant Proc 2010 Jun;42(5):1704-7. doi: 10.1016/j.transproceed.2009.11.045. PMID: 20620505
Serrated lesions of the appendix: a morphologic and immunohistochemical appraisal.
Bellizzi AM, Rock J, Marsh WL, Frankel WL
Am J Clin Pathol 2010 Apr;133(4):623-32. doi: 10.1309/AJCP1UJPX6UURLCH. PMID: 20231616
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Multifocal neoplasia involving the colon and appendix in ulcerative colitis: pathological and molecular features.
Lyda MH, Noffsinger A, Belli J, Fischer J, Fenoglio-Preiser CM
Gastroenterology 1998 Dec;115(6):1566-73. doi: 10.1016/s0016-5085(98)70037-x. PMID: 9834286

Prognosis

Mucocoele of the appendix.
Oyeh E, Nsaful J, Bediako-Bowan A, Gbadamosi H, Mensah YB, Adu-Aryee NA, Nyarko V
Ghana Med J 2024 Mar;58(1):109-114. doi: 10.4314/gmj.v58i1.15. PMID: 38957279Free PMC Article
Mucocoele and mucinous tumours of the appendix: A review of the literature.
Rymer B, Forsythe RO, Husada G
Int J Surg 2015 Jun;18:132-5. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.052. PMID: 25917270
Laparoscopic appendectomy.
Agarwala N, Liu CY
J Am Assoc Gynecol Laparosc 2003 May;10(2):166-8. doi: 10.1016/s1074-3804(05)60292-7. PMID: 12732765
Benign mucinous cystadenoma of the appendix. Report of 3 cases. Review of the literature.
Hansson B, Hubens G, Vaneerdeweg W
Acta Chir Belg 2002 Feb;102(1):63-5. doi: 10.1080/00015458.2002.11681161. PMID: 11925744
Mucosal hyperplasia, mucinous cystadenoma, and mucinous cystadenocarcinoma of the appendix. A re-evaluation of appendiceal "mucocele".
Higa E, Rosai J, Pizzimbono CA, Wise L
Cancer 1973 Dec;32(6):1525-41. doi: 10.1002/1097-0142(197312)32:6<1525::aid-cncr2820320632>3.0.co;2-c. PMID: 4757938

Clinical prediction guides

Histopathological features of incidental appendectomy specimens obtained from living liver donors.
Akbulut S, Koç C, Sarıcı B, Özcan M, Şamdancı E, Yılmaz S
Turk J Gastroenterol 2020 Mar;31(3):257-263. doi: 10.5152/tjg.2020.19010. PMID: 32343238Free PMC Article
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Appendiceal mucocele - Case Report and Review of the Literature.
Asenov Y, Korukov B, Penkov N, Sedloev T, Tihtchev V, Hadzhiysca V, Damianov D
Chirurgia (Bucur) 2015 Nov-Dec;110(6):565-9. PMID: 26713834
Massive mucinous cystadenoma of the appendix with intussusception in an adult: usefulness of reconstructed computed tomography images.
Okuda I, Matsuda M, Noguchi H, Kokubo T
Radiat Med 2008 Feb;26(2):88-91. Epub 2008 Feb 27 doi: 10.1007/s11604-007-0201-z. PMID: 18301985
The coexistence of low-grade mucinous neoplasms of the appendix and appendiceal diverticula: a possible role in the pathogenesis of pseudomyxoma peritonei.
Lamps LW, Gray GF Jr, Dilday BR, Washington MK
Mod Pathol 2000 May;13(5):495-501. doi: 10.1038/modpathol.3880086. PMID: 10824920

Recent systematic reviews

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

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