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Colon small cell neuroendocrine carcinoma

MedGen UID:
232087
•Concept ID:
C1333099
•
Neoplastic Process
Synonyms: colon Oat cell carcinoma; Colon Small Cell Carcinoma; colon small cell carcinoma; colon small cell neuroendocrine cancer; Colon Small Cell Neuroendocrine Carcinoma; colon small cell neuroendocrine carcinoma; colonic Oat cell carcinoma; Colonic Small Cell Carcinoma; colonic small cell carcinoma; Oat cell carcinoma of colon; Oat cell carcinoma of the colon; Oat cell colon carcinoma; Small Cell Carcinoma of Colon; small cell carcinoma of colon; Small Cell Carcinoma of the Colon; small cell carcinoma of the colon; Small Cell Colon Carcinoma; small cell colon carcinoma
 
Monarch Initiative: MONDO:0003978

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon small cell neuroendocrine carcinoma

Professional guidelines

PubMed

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors.
Li X, Yao J, Qu C, Luo L, Li B, Zhang Y, Zhu Z, Qiu Y, Hua H
J Transl Med 2024 Apr 17;22(1):362. doi: 10.1186/s12967-024-05133-7. PMID: 38632563Free PMC Article
Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route.
Gao Q, Chen N, Li B, Zu M, Ma Y, Xu H, Zhu Z, Reis RL, Kundu SC, Xiao B
J Nanobiotechnology 2024 Jan 3;22(1):4. doi: 10.1186/s12951-023-02286-3. PMID: 38169394Free PMC Article
Guidelines for the management of iron deficiency anaemia.
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Colonic mucosal diffuse congestion associated with Osimertinib.
Ren XJ, Lei MH, Cheng YX, Luo Y
J Oncol Pharm Pract 2023 Oct;29(7):1781-1784. Epub 2023 Jun 20 doi: 10.1177/10781552231184182. PMID: 37338466
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial.
Wu YL, Cheng Y, Zhou X, Lee KH, Nakagawa K, Niho S, Tsuji F, Linke R, Rosell R, Corral J, Migliorino MR, Pluzanski A, Sbar EI, Wang T, White JL, Nadanaciva S, Sandin R, Mok TS
Lancet Oncol 2017 Nov;18(11):1454-1466. Epub 2017 Sep 25 doi: 10.1016/S1470-2045(17)30608-3. PMID: 28958502

Diagnosis

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors.
Li X, Yao J, Qu C, Luo L, Li B, Zhang Y, Zhu Z, Qiu Y, Hua H
J Transl Med 2024 Apr 17;22(1):362. doi: 10.1186/s12967-024-05133-7. PMID: 38632563Free PMC Article
Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Small cell neuroendocrine carcinoma arising in cystic duplication of colon.
Ling D, Chirchir M, Alzahrani N, Morris DL
ANZ J Surg 2022 Mar;92(3):608-610. Epub 2021 Jul 28 doi: 10.1111/ans.17105. PMID: 34319648
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
The malignant colonic polyp Review of biological, clinical parameters and treatment.
Del Rio P, Cozzani F, Viani L, Nisi P, Rossini M, Sianesi M
Ann Ital Chir 2015;86:396-405. PMID: 26567607

Therapy

Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial.
Wu YL, Cheng Y, Zhou X, Lee KH, Nakagawa K, Niho S, Tsuji F, Linke R, Rosell R, Corral J, Migliorino MR, Pluzanski A, Sbar EI, Wang T, White JL, Nadanaciva S, Sandin R, Mok TS
Lancet Oncol 2017 Nov;18(11):1454-1466. Epub 2017 Sep 25 doi: 10.1016/S1470-2045(17)30608-3. PMID: 28958502
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine.
Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R
Science 2017 Sep 15;357(6356):1156-1160. doi: 10.1126/science.aah5043. PMID: 28912244Free PMC Article
Muscle wasting in cancer.
Johns N, Stephens NA, Fearon KC
Int J Biochem Cell Biol 2013 Oct;45(10):2215-29. Epub 2013 Jun 11 doi: 10.1016/j.biocel.2013.05.032. PMID: 23770121

Prognosis

Folate Receptor Alpha-A Novel Approach to Cancer Therapy.
Gonzalez T, Muminovic M, Nano O, Vulfovich M
Int J Mol Sci 2024 Jan 15;25(2) doi: 10.3390/ijms25021046. PMID: 38256120Free PMC Article
The emerging roles of CEACAM6 in human cancer (Review).
Wu G, Wang D, Xiong F, Wang Q, Liu W, Chen J, Chen Y
Int J Oncol 2024 Mar;64(3) Epub 2024 Jan 19 doi: 10.3892/ijo.2024.5615. PMID: 38240103Free PMC Article
Appendiceal cancer : a review of the literature.
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial.
Wu YL, Cheng Y, Zhou X, Lee KH, Nakagawa K, Niho S, Tsuji F, Linke R, Rosell R, Corral J, Migliorino MR, Pluzanski A, Sbar EI, Wang T, White JL, Nadanaciva S, Sandin R, Mok TS
Lancet Oncol 2017 Nov;18(11):1454-1466. Epub 2017 Sep 25 doi: 10.1016/S1470-2045(17)30608-3. PMID: 28958502

Clinical prediction guides

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors.
Li X, Yao J, Qu C, Luo L, Li B, Zhang Y, Zhu Z, Qiu Y, Hua H
J Transl Med 2024 Apr 17;22(1):362. doi: 10.1186/s12967-024-05133-7. PMID: 38632563Free PMC Article
Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Colonic mucosal diffuse congestion associated with Osimertinib.
Ren XJ, Lei MH, Cheng YX, Luo Y
J Oncol Pharm Pract 2023 Oct;29(7):1781-1784. Epub 2023 Jun 20 doi: 10.1177/10781552231184182. PMID: 37338466
Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies.
Oster P, Vaillant L, Riva E, McMillan B, Begka C, Truntzer C, Richard C, Leblond MM, Messaoudene M, Machremi E, Limagne E, Ghiringhelli F, Routy B, Verdeil G, Velin D
Gut 2022 Mar;71(3):457-466. Epub 2021 Jul 12 doi: 10.1136/gutjnl-2020-323392. PMID: 34253574Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681

Recent systematic reviews

Risk of Cancer in Inflammatory Bowel Diseases: Umbrella Review and Reanalysis of Meta-analyses.
Piovani D, Hassan C, Repici A, Rimassa L, Carlo-Stella C, Nikolopoulos GK, Riboli E, Bonovas S
Gastroenterology 2022 Sep;163(3):671-684. Epub 2022 May 26 doi: 10.1053/j.gastro.2022.05.038. PMID: 35643170
Cruciferous vegetable consumption and multiple health outcomes: an umbrella review of 41 systematic reviews and meta-analyses of 303 observational studies.
Li YZ, Yang ZY, Gong TT, Liu YS, Liu FH, Wen ZY, Li XY, Gao C, Luan M, Zhao YH, Wu QJ
Food Funct 2022 Apr 20;13(8):4247-4259. doi: 10.1039/d1fo03094a. PMID: 35352732
Association between genetic mutations and risk of venous thromboembolism in patients with solid tumor malignancies: A systematic review and meta-analysis.
Abufarhaneh M, Pandya RK, Alkhaja A, Iansavichene A, Welch S, Lazo-Langner A
Thromb Res 2022 May;213:47-56. Epub 2022 Mar 4 doi: 10.1016/j.thromres.2022.02.022. PMID: 35290837
Change of Circulating and Tissue-Based miR-20a in Human Cancers and Associated Prognostic Implication: A Systematic Review and Meta-Analysis.
Zhang Q, Wang Q, Sun W, Gao F, Liu L, Cheng L, Li Z
Biomed Res Int 2018;2018:6124927. Epub 2018 Nov 25 doi: 10.1155/2018/6124927. PMID: 30596096Free PMC Article
Bevacizumab and wound-healing complications: a systematic review and meta-analysis of randomized controlled trials.
Zhang H, Huang Z, Zou X, Liu T
Oncotarget 2016 Dec 13;7(50):82473-82481. doi: 10.18632/oncotarget.12666. PMID: 27756883Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

    Reviews

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