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Cutaneous myxoma

MedGen UID:
232400
•Concept ID:
C1333178
•
Neoplastic Process
Synonyms: Cutaneous Myxoma; Skin Myxoma
 
HPO: HP:0030428

Definition

A myxoma originating in the skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous myxoma

Professional guidelines

PubMed

MANAGEMENT OF ENDOCRINE DISEASE: Carney complex: clinical and genetic update 20 years after the identification of the CNC1 (PRKAR1A) gene.
Bouys L, Bertherat J
Eur J Endocrinol 2021 Mar;184(3):R99-R109. doi: 10.1530/EJE-20-1120. PMID: 33444222
Cutaneous mucinoses: microscopic criteria for diagnosis.
Rongioletti F, Rebora A
Am J Dermatopathol 2001 Jun;23(3):257-67. doi: 10.1097/00000372-200106000-00022. PMID: 11391115
Cutaneous melanoma with myxoid features: twelve cases with differential diagnosis.
Hitchcock MG, McCalmont TH, White WL
Am J Surg Pathol 1999 Dec;23(12):1506-13. doi: 10.1097/00000478-199912000-00008. PMID: 10584704

Recent clinical studies

Etiology

A clinicopathologic analysis of 54 cases of cutaneous myxoma.
Sharma A, Khaitan N, Ko JS, Bergfeld WF, Piliang M, Rubin BP, Goldblum JR, Billings SD
Hum Pathol 2022 Feb;120:71-76. Epub 2021 Dec 27 doi: 10.1016/j.humpath.2021.12.003. PMID: 34968506
Cutaneous follicular mucinous nevus presenting with congenital grouped papules and plaques initially misdiagnosed as a cutaneous myxoma.
Fischer AS, Pei S, McMahon P, Taylor JA, Elenitsas R, Rubin AI
J Cutan Pathol 2021 Jan;48(1):1-5. doi: 10.1111/cup.13701. PMID: 33351263
Sporadic Carney complex without PRKAR1A mutation in a young patient with ischemic stroke.
Aguiar de Sousa D, Gouveia AI, Wessling A, Geraldes R, Canhão P
J Stroke Cerebrovasc Dis 2015 Mar;24(3):e79-81. Epub 2015 Jan 6 doi: 10.1016/j.jstrokecerebrovasdis.2014.11.001. PMID: 25576349
Heterogeneity of skin manifestations in patients with Carney complex.
Mateus C, Palangié A, Franck N, Groussin L, Bertagna X, Avril MF, Bertherat J, Dupin N
J Am Acad Dermatol 2008 Nov;59(5):801-10. Epub 2008 Sep 19 doi: 10.1016/j.jaad.2008.07.032. PMID: 18804312
Superficial angiomyxoma (cutaneous myxoma): a clinicopathologic study of 17 cases arising in the genital region.
Fetsch JF, Laskin WB, Tavassoli FA
Int J Gynecol Pathol 1997 Oct;16(4):325-34. doi: 10.1097/00004347-199710000-00006. PMID: 9421071

Diagnosis

FDG PET/CT findings of superficial angiomyxoma.
Nishio J, Iwasaki H, Aoki M, Nabeshima K, Naito M
Clin Nucl Med 2014 Apr;39(4):367-70. doi: 10.1097/RLU.0b013e3182995e15. PMID: 23797232
Heterogeneity of skin manifestations in patients with Carney complex.
Mateus C, Palangié A, Franck N, Groussin L, Bertagna X, Avril MF, Bertherat J, Dupin N
J Am Acad Dermatol 2008 Nov;59(5):801-10. Epub 2008 Sep 19 doi: 10.1016/j.jaad.2008.07.032. PMID: 18804312
Solitary cutaneous myxoma.
Alaiti S, Nelson FP, Ryoo JW
J Am Acad Dermatol 2000 Aug;43(2 Pt 2):377-9. doi: 10.1067/mjd.2000.101878. PMID: 10901728
Myxoid dermatofibroma.
Zelger BG, Calonje E, Zelger B
Histopathology 1999 Apr;34(4):357-64. doi: 10.1046/j.1365-2559.1999.00633.x. PMID: 10231403
Cutaneous myxomas. A major component of the complex of myxomas, spotty pigmentation, and endocrine overactivity.
Carney JA, Headington JT, Su WP
Arch Dermatol 1986 Jul;122(7):790-8. doi: 10.1001/archderm.122.7.790. PMID: 3729510

Therapy

Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169
Multiple cutaneous focal mucinoses with hypothyroidism.
Jakubovic HR, Salama SS, Rosenthal D
Ann Intern Med 1982 Jan;96(1):56-8. doi: 10.7326/0003-4819-96-1-56. PMID: 7053704

Prognosis

Sporadic Carney complex without PRKAR1A mutation in a young patient with ischemic stroke.
Aguiar de Sousa D, Gouveia AI, Wessling A, Geraldes R, Canhão P
J Stroke Cerebrovasc Dis 2015 Mar;24(3):e79-81. Epub 2015 Jan 6 doi: 10.1016/j.jstrokecerebrovasdis.2014.11.001. PMID: 25576349
Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma".
Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL
Am J Surg Pathol 2014 Jan;38(1):94-105. doi: 10.1097/PAS.0b013e3182a0a150. PMID: 24145644
Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes.
Fetsch JF, Laskin WB, Miettinen M
Hum Pathol 2001 Jul;32(7):704-14. doi: 10.1053/hupa.2001.25903. PMID: 11486169
Superficial angiomyxoma (cutaneous myxoma): a clinicopathologic study of 17 cases arising in the genital region.
Fetsch JF, Laskin WB, Tavassoli FA
Int J Gynecol Pathol 1997 Oct;16(4):325-34. doi: 10.1097/00004347-199710000-00006. PMID: 9421071
Multiple cutaneous myxomas coinciding with repeated cardiac myxomas. A syndrome.
Bier B, Seitz G, Bach R, Volkmer I, Fröhlig G
Thorac Cardiovasc Surg 1989 Oct;37(5):317-9. doi: 10.1055/s-2007-1020342. PMID: 2588251

Clinical prediction guides

Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.
Hafeez F, Krakowski AC, Lian CG, Nazarian RM, Maleszewski JJ
Histopathology 2022 May;80(6):1001-1003. Epub 2022 Mar 17 doi: 10.1111/his.14568. PMID: 34532875
Sporadic Carney complex without PRKAR1A mutation in a young patient with ischemic stroke.
Aguiar de Sousa D, Gouveia AI, Wessling A, Geraldes R, Canhão P
J Stroke Cerebrovasc Dis 2015 Mar;24(3):e79-81. Epub 2015 Jan 6 doi: 10.1016/j.jstrokecerebrovasdis.2014.11.001. PMID: 25576349
Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma".
Torres-Mora J, Dry S, Li X, Binder S, Amin M, Folpe AL
Am J Surg Pathol 2014 Jan;38(1):94-105. doi: 10.1097/PAS.0b013e3182a0a150. PMID: 24145644
CD44 and hyaluronate expression in follicular mucinosis.
Kaya G, Augsburger E, Chavaz P, Saurat JH
J Cutan Pathol 2006 Mar;33(3):227-30. doi: 10.1111/j.0303-6987.2006.00463.x. PMID: 16466510
Multiple cutaneous myxomas coinciding with repeated cardiac myxomas. A syndrome.
Bier B, Seitz G, Bach R, Volkmer I, Fröhlig G
Thorac Cardiovasc Surg 1989 Oct;37(5):317-9. doi: 10.1055/s-2007-1020342. PMID: 2588251

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