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Diffuse infiltrative lymphocytosis syndrome

MedGen UID:
232428
•Concept ID:
C1333292
•
Disease or Syndrome
Synonyms: diffuse infiltra. lymph. sydrome; diffuse infiltra. lymph. syndrome; Diffuse Infiltrative Lymphocytosis Syndrome; diffuse infiltrative lymphocytosis syndrome; DILS - diffuse infiltrative lymphocytosis syndrome
SNOMED CT: Diffuse infiltrative lymphocytosis syndrome (449784008); DILS - diffuse infiltrative lymphocytosis syndrome (449784008)
 
Monarch Initiative: MONDO:0003963

Definition

This is usually an oligoclonal CD8+ lymphocytic infiltration of various organs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse infiltrative lymphocytosis syndrome

Professional guidelines

PubMed

HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment.
Wulff EA, Wang AK, Simpson DM
Drugs 2000 Jun;59(6):1251-60. doi: 10.2165/00003495-200059060-00005. PMID: 10882161
Primary pulmonary hypertension in HIV infection: an outcome determined by particular HLA class II alleles.
Morse JH, Barst RJ, Itescu S, Flaster ER, Sinha G, Zhang Y, Fotino M
Am J Respir Crit Care Med 1996 Apr;153(4 Pt 1):1299-301. doi: 10.1164/ajrccm.153.4.8616557. PMID: 8616557

Recent clinical studies

Etiology

Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study.
Chen M, Yen YF, Lan YC, Jen IA, Chuang PH, Lee CY, Lee Y, Lin YA, Arthur Chen YM
J Acquir Immune Defic Syndr 2018 Oct 1;79(2):158-163. doi: 10.1097/QAI.0000000000001802. PMID: 29995702
Human immunodeficiency virus-associated peripheral neuropathies.
Ferrari S, Vento S, Monaco S, Cavallaro T, Cainelli F, Rizzuto N, Temesgen Z
Mayo Clin Proc 2006 Feb;81(2):213-9. doi: 10.4065/81.2.213. PMID: 16471077
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa.
McArthur CP, Subtil-DeOliveira A, Palmer D, Fiorella RM, Gustafson S, Tira D, Miranda RN
Arch Pathol Lab Med 2000 Dec;124(12):1773-9. doi: 10.5858/2000-124-1773-COSDIL. PMID: 11100056
The diffuse infiltrative lymphocytosis syndrome. Clinical and immunogenetic features in 35 patients.
Kazi S, Cohen PR, Williams F, Schempp R, Reveille JD
AIDS 1996 Apr;10(4):385-91. PMID: 8728042
Diffuse infiltrative lymphocytosis syndrome in children and adults infected with HIV-1: a model of rheumatic illness caused by acquired viral infection.
Itescu S
Am J Reprod Immunol 1992 Oct-Dec;28(3-4):247-50. doi: 10.1111/j.1600-0897.1992.tb00806.x. PMID: 1285893

Diagnosis

The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.
Ghrenassia E, Martis N, Boyer J, Burel-Vandenbos F, Mekinian A, Coppo P
J Autoimmun 2015 May;59:19-25. Epub 2015 Feb 7 doi: 10.1016/j.jaut.2015.01.010. PMID: 25660200
Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome.
Zafrani L, Coppo P, Dettwiler S, Molinier-Frenkel V, Agbalika F, Guiard-Schmid JB, Pialoux G, Xu-Dubois YC, Rondeau E, Hertig A
Kidney Int 2007 Jul;72(2):219-24. Epub 2007 Mar 14 doi: 10.1038/sj.ki.5002207. PMID: 17361111
Human immunodeficiency virus-associated peripheral neuropathies.
Ferrari S, Vento S, Monaco S, Cavallaro T, Cainelli F, Rizzuto N, Temesgen Z
Mayo Clin Proc 2006 Feb;81(2):213-9. doi: 10.4065/81.2.213. PMID: 16471077
Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1.
Hansen A, Feist E, Hiepe F, Burmester GR, Scholze J
Arthritis Rheum 1999 Mar;42(3):578-80. doi: 10.1002/1529-0131(199904)42:3<578::AID-ANR26>3.0.CO;2-B. PMID: 10088785
Diffuse infiltrative lymphocytosis syndrome in a patient not infected with the human immunodeficiency virus.
Agah R, Sockell M, Felsovayni A
West J Med 1996 Mar;164(3):266-8. PMID: 8775946Free PMC Article

Therapy

Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands.
Nizamuddin I, Koulen P, McArthur CP
Int J Mol Sci 2018 Sep 13;19(9) doi: 10.3390/ijms19092747. PMID: 30217034Free PMC Article
Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study.
Chen M, Yen YF, Lan YC, Jen IA, Chuang PH, Lee CY, Lee Y, Lin YA, Arthur Chen YM
J Acquir Immune Defic Syndr 2018 Oct 1;79(2):158-163. doi: 10.1097/QAI.0000000000001802. PMID: 29995702
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.
Ghrenassia E, Martis N, Boyer J, Burel-Vandenbos F, Mekinian A, Coppo P
J Autoimmun 2015 May;59:19-25. Epub 2015 Feb 7 doi: 10.1016/j.jaut.2015.01.010. PMID: 25660200
Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection.
Reveille JD, Williams FM
Best Pract Res Clin Rheumatol 2006 Dec;20(6):1159-79. doi: 10.1016/j.berh.2006.08.015. PMID: 17127202
Human immunodeficiency virus-associated peripheral neuropathies.
Ferrari S, Vento S, Monaco S, Cavallaro T, Cainelli F, Rizzuto N, Temesgen Z
Mayo Clin Proc 2006 Feb;81(2):213-9. doi: 10.4065/81.2.213. PMID: 16471077

Prognosis

The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.
Ghrenassia E, Martis N, Boyer J, Burel-Vandenbos F, Mekinian A, Coppo P
J Autoimmun 2015 May;59:19-25. Epub 2015 Feb 7 doi: 10.1016/j.jaut.2015.01.010. PMID: 25660200
Diffuse infiltrative CD8+ lymphocytosis syndrome: review of the literature and report of a case.
Feller L, White JP, Bouckaert M, Muthuphei MN
SADJ 2007 Aug;62(7):314-7. PMID: 18019812
Selected rare, noninfectious syndromes associated with HIV infection.
Eaton ME
Top HIV Med 2005 Jun-Jul;13(2):75-8. PMID: 16082058
HIV-associated parotid lymphoepithelial cysts.
Mandel L, Hong J
J Am Dent Assoc 1999 Apr;130(4):528-32. doi: 10.14219/jada.archive.1999.0247. PMID: 10203903
Adult immunodeficiency and rheumatic disease.
Itescu S
Rheum Dis Clin North Am 1996 Feb;22(1):53-73. doi: 10.1016/s0889-857x(05)70262-3. PMID: 8907065

Clinical prediction guides

The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review.
Ghrenassia E, Martis N, Boyer J, Burel-Vandenbos F, Mekinian A, Coppo P
J Autoimmun 2015 May;59:19-25. Epub 2015 Feb 7 doi: 10.1016/j.jaut.2015.01.010. PMID: 25660200
Acute kidney injury in patients with human immunodeficiency virus infection.
Cohen SD, Chawla LS, Kimmel PL
Curr Opin Crit Care 2008 Dec;14(6):647-53. doi: 10.1097/MCC.0b013e3283186f43. PMID: 19005305
Rheumatic conditions in human immunodeficiency virus infection.
Walker UA, Tyndall A, Daikeler T
Rheumatology (Oxford) 2008 Jul;47(7):952-9. Epub 2008 Apr 15 doi: 10.1093/rheumatology/ken132. PMID: 18413346
The changing spectrum of rheumatic disease in human immunodeficiency virus infection.
Reveille JD
Semin Arthritis Rheum 2000 Dec;30(3):147-66. doi: 10.1053/sarh.2000.16527. PMID: 11124280
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa.
McArthur CP, Subtil-DeOliveira A, Palmer D, Fiorella RM, Gustafson S, Tira D, Miranda RN
Arch Pathol Lab Med 2000 Dec;124(12):1773-9. doi: 10.5858/2000-124-1773-COSDIL. PMID: 11100056

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