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Breast Ductal Carcinoma with Squamous Metaplasia

MedGen UID:
232437
•Concept ID:
C1333319
•
Neoplastic Process
Synonyms: Ductal Breast Carcinoma with Squamous Metaplasia; Ductal Carcinoma of Breast with Squamous Metaplasia; Ductal Carcinoma of the Breast with Squamous Metaplasia

Definition

An invasive breast carcinoma characterized by the presence of a predominant squamous cell component that is admixed with the ductal carcinomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Ductal Carcinoma with Squamous Metaplasia

Recent clinical studies

Etiology

Metaplastic breast carcinoma: Analysis of clinical and pathologic features, a five-year study.
Chaudhary D, Balhara K, Mandal S, Mallya V, Tomar R, Khurana N, Bains L
J Cancer Res Ther 2023 Jul-Sep;19(5):1226-1230. doi: 10.4103/jcrt.jcrt_1229_21. PMID: 37787287
Metaplastic breast cancers frequently express immune checkpoint markers FOXP3 and PD-L1.
Kalaw E, Lim M, Kutasovic JR, Sokolova A, Taege L, Johnstone K, Bennett J, Saunus JM, Niland C, Ferguson K, Gresshoff I, Bettington M, Pathmanathan N, Tse GM, Papadimos D, Pathmanathan R, Harris G, Yamaguchi R, Tan PH, Fox S, O'Toole SA, Simpson PT, Lakhani SR, McCart Reed AE
Br J Cancer 2020 Nov;123(11):1665-1672. Epub 2020 Sep 17 doi: 10.1038/s41416-020-01065-3. PMID: 32939056Free PMC Article
Genomic profiling of metaplastic breast carcinomas reveals genetic heterogeneity and relationship to ductal carcinoma.
Krings G, Chen YY
Mod Pathol 2018 Nov;31(11):1661-1674. Epub 2018 Jun 26 doi: 10.1038/s41379-018-0081-z. PMID: 29946183
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature.
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
Unique clinicopathological features of metaplastic breast carcinoma compared with invasive ductal carcinoma and poor prognostic indicators.
Song Y, Liu X, Zhang G, Song H, Ren Y, He X, Wang Y, Zhang J, Zhang Y, Sun S, Liang X, Sun Q, Pang D
World J Surg Oncol 2013 Jun 6;11:129. doi: 10.1186/1477-7819-11-129. PMID: 23738706Free PMC Article

Diagnosis

Metaplastic breast carcinoma: Analysis of clinical and pathologic features, a five-year study.
Chaudhary D, Balhara K, Mandal S, Mallya V, Tomar R, Khurana N, Bains L
J Cancer Res Ther 2023 Jul-Sep;19(5):1226-1230. doi: 10.4103/jcrt.jcrt_1229_21. PMID: 37787287
Metastatic metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration.
Nguyen DN, Kawamoto S, Cimino-Mathews A, Illei PB, Rosenthal DL, VandenBussche CJ
Diagn Cytopathol 2015 Oct;43(10):844-9. Epub 2015 Aug 3 doi: 10.1002/dc.23321. PMID: 26238413
Metaplastic carcinoma of the breast.
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252
Metaplastic carcinoma of the breast: cytological diagnosis and diagnostic pitfalls.
Joshi D, Singh P, Zonunfawni Y, Gangane N
Acta Cytol 2011;55(4):313-8. Epub 2011 Jul 22 doi: 10.1159/000326932. PMID: 21791899
Metaplastic breast carcinoma with melanocytic differentiation.
Bendic A, Bozic M, Durdov MG
Pathol Int 2009 Sep;59(9):676-80. doi: 10.1111/j.1440-1827.2009.02426.x. PMID: 19712138

Therapy

Exuberant Squamous Metaplasia with Calcification Following Intraoperative Radiotherapy for Breast Carcinoma: Report of an Unusual Case and Retrospective Review of Cases from a Single Institution.
Ginter PS, Ng J, Zhuo R, Swistel AJ, D'Alfonso TM
Breast J 2017 May;23(3):267-274. Epub 2016 Nov 30 doi: 10.1111/tbj.12733. PMID: 27900811
Metaplastic Breast Cancer: Molecular Typing and Identification of Potential Targeted Therapies at a Single Institution.
Edenfield J, Schammel C, Collins J, Schammel D, Edenfield WJ
Clin Breast Cancer 2017 Feb;17(1):e1-e10. Epub 2016 Jul 25 doi: 10.1016/j.clbc.2016.07.004. PMID: 27568101
Metaplastic carcinoma of the breast.
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252
Metaplastic breast carcinoma with melanocytic differentiation.
Bendic A, Bozic M, Durdov MG
Pathol Int 2009 Sep;59(9):676-80. doi: 10.1111/j.1440-1827.2009.02426.x. PMID: 19712138
Squamous cell carcinoma of the breast following silicone injection of the breasts.
Smith LF, Smith TT, Yeary E, McGee JM, Malnar K
J Okla State Med Assoc 1999 Mar;92(3):126-30. PMID: 10087675

Prognosis

Metaplastic breast carcinoma: Analysis of clinical and pathologic features, a five-year study.
Chaudhary D, Balhara K, Mandal S, Mallya V, Tomar R, Khurana N, Bains L
J Cancer Res Ther 2023 Jul-Sep;19(5):1226-1230. doi: 10.4103/jcrt.jcrt_1229_21. PMID: 37787287
Eccrine ductal and acrosyringeal metaplasia in breast carcinomas: report of eight cases.
Tot T
Virchows Arch 2019 Mar;474(3):383-387. Epub 2018 Nov 22 doi: 10.1007/s00428-018-2488-9. PMID: 30467599
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature.
El Zein D, Hughes M, Kumar S, Peng X, Oyasiji T, Jabbour H, Khoury T
Clin Breast Cancer 2017 Aug;17(5):382-391. Epub 2017 Apr 26 doi: 10.1016/j.clbc.2017.04.009. PMID: 28529029Free PMC Article
Impact of Squamous Differentiation in Breast Carcinoma.
Pai T, Shet T, Desai S, Patil A, Nair N, Parmar V, Gupta S, Budrukkar A, Sarin R, Badwe R
Int J Surg Pathol 2016 Sep;24(6):483-9. Epub 2016 Apr 12 doi: 10.1177/1066896916642290. PMID: 27076454
Metaplastic carcinoma of the breast.
McKinnon E, Xiao P
Arch Pathol Lab Med 2015 Jun;139(6):819-22. doi: 10.5858/arpa.2013-0358-RS. PMID: 26030252

Clinical prediction guides

An exceptional metaplastic lobular breast carcinoma diagnosed through exome sequencing.
Bergeron A, Desmoulins I, Beltjens F, Causeret S, Charon-Barra C, Martin E, Richard C, Boidot R, Arnould L
J Clin Pathol 2020 Sep;73(9):597-601. Epub 2020 Jan 24 doi: 10.1136/jclinpath-2019-205783. PMID: 31980561
Whole-Exome Sequencing of Metaplastic Breast Carcinoma Indicates Monoclonality with Associated Ductal Carcinoma Component.
Avigdor BE, Beierl K, Gocke CD, Zabransky DJ, Cravero K, Kyker-Snowman K, Button B, Chu D, Croessmann S, Cochran RL, Connolly RM, Park BH, Wheelan SJ, Cimino-Mathews A
Clin Cancer Res 2017 Aug 15;23(16):4875-4884. Epub 2017 Apr 19 doi: 10.1158/1078-0432.CCR-17-0108. PMID: 28424200Free PMC Article
Metaplastic carcinoma of the breast: cytological diagnosis and diagnostic pitfalls.
Joshi D, Singh P, Zonunfawni Y, Gangane N
Acta Cytol 2011;55(4):313-8. Epub 2011 Jul 22 doi: 10.1159/000326932. PMID: 21791899
Squamous metaplasia of the breast simulating a malignant neoplasm: a case.
Mascolo M, Mignogna C, De Cecio R, Bonuso C, Accurso A
Eur J Cancer Care (Engl) 2009 Nov;18(6):650-2. Epub 2009 Apr 23 doi: 10.1111/j.1365-2354.2008.00929.x. PMID: 19456849
Eccrine ductal and acrosyringeal differentiation of the breast epithelium--a lesion associated with some metaplastic breast carcinomas.
Tot T
Virchows Arch 2006 Nov;449(5):565-71. Epub 2006 Oct 3 doi: 10.1007/s00428-006-0281-7. PMID: 17016720

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