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Grade II Prostatic Intraepithelial Neoplasia

MedGen UID:
232566
•Concept ID:
C1333864
•
Neoplastic Process

Definition

High grade prostatic intraepithelial neoplasia characterized by the presence of moderate architectural and cytologic abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade II Prostatic Intraepithelial Neoplasia

Professional guidelines

PubMed

A working group classification of focal prostate atrophy lesions.
De Marzo AM, Platz EA, Epstein JI, Ali T, Billis A, Chan TY, Cheng L, Datta M, Egevad L, Ertoy-Baydar D, Farre X, Fine SW, Iczkowski KA, Ittmann M, Knudsen BS, Loda M, Lopez-Beltran A, Magi-Galluzzi C, Mikuz G, Montironi R, Pikarsky E, Pizov G, Rubin MA, Samaratunga H, Sebo T, Sesterhenn IA, Shah RB, Signoretti S, Simko J, Thomas G, Troncoso P, Tsuzuki TT, van Leenders GJ, Yang XJ, Zhou M, Figg WD, Hoque A, Lucia MS
Am J Surg Pathol 2006 Oct;30(10):1281-91. doi: 10.1097/01.pas.0000213289.50660.be. PMID: 17001160

Recent clinical studies

Etiology

The Biochemical Effects of Silver Nanoparticles and Spirulina Extract on Experimentally Induced Prostatic Cancer in Rats.
El-Magid ADA, AbdEl-Hamid OM, Younes MA
Biol Trace Elem Res 2023 Apr;201(4):1935-1945. Epub 2022 Jun 11 doi: 10.1007/s12011-022-03298-0. PMID: 35689758Free PMC Article
Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial.
Micali S, Territo A, Pirola GM, Ferrari N, Sighinolfi MC, Martorana E, Navarra M, Bianchi G
Arch Ital Urol Androl 2017 Oct 3;89(3):197-202. doi: 10.4081/aiua.2017.3.197. PMID: 28969404
A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia.
Gann PH, Deaton RJ, Rueter EE, van Breemen RB, Nonn L, Macias V, Han M, Ananthanarayanan V
Nutr Cancer 2015;67(7):1104-12. doi: 10.1080/01635581.2015.1075560. PMID: 26422197Free PMC Article
High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer.
Willems-Jones A, Kavanagh L, Clouston D, Bolton D; kConFab Investigators, Fox S, Thorne H
BJU Int 2012 Dec;110(11 Pt C):E1181-6. Epub 2012 Oct 4 doi: 10.1111/j.1464-410X.2012.11519.x. PMID: 23035815
Prostatic intraepithelial neoplasia and apoptosis in benign prostatic hyperplasia before and after the Chernobyl accident in Ukraine.
Vosianov AF, Romanenko AM, Zabarko LB, Szende B, Wang CY, Landas S, Haas GP
Pathol Oncol Res 1999;5(1):28-31. doi: 10.1053/paor.1999.0028. PMID: 10079374

Diagnosis

The Biochemical Effects of Silver Nanoparticles and Spirulina Extract on Experimentally Induced Prostatic Cancer in Rats.
El-Magid ADA, AbdEl-Hamid OM, Younes MA
Biol Trace Elem Res 2023 Apr;201(4):1935-1945. Epub 2022 Jun 11 doi: 10.1007/s12011-022-03298-0. PMID: 35689758Free PMC Article
Preneoplasia in the prostate gland with emphasis on high grade prostatic intraepithelial neoplasia.
Merrimen JL, Evans AJ, Srigley JR
Pathology 2013 Apr;45(3):251-63. doi: 10.1097/PAT.0b013e32835f6134. PMID: 23478231
High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer.
Willems-Jones A, Kavanagh L, Clouston D, Bolton D; kConFab Investigators, Fox S, Thorne H
BJU Int 2012 Dec;110(11 Pt C):E1181-6. Epub 2012 Oct 4 doi: 10.1111/j.1464-410X.2012.11519.x. PMID: 23035815
Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer.
Yee DS, Narula N, Ramzy I, Boker J, Ahlering TE, Skarecky DW, Ornstein DK
Arch Pathol Lab Med 2007 Jun;131(6):902-8. doi: 10.5858/2007-131-902-RAIPEI. PMID: 17550317
Comparison of annexin II, p63 and alpha-methylacyl-CoA racemase immunoreactivity in prostatic tissue: a tissue microarray study.
Stewart J, Fleshner N, Cole H, Sweet J
J Clin Pathol 2007 Jul;60(7):773-80. Epub 2006 Aug 17 doi: 10.1136/jcp.2006.040808. PMID: 16916997Free PMC Article

Therapy

Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial.
Micali S, Territo A, Pirola GM, Ferrari N, Sighinolfi MC, Martorana E, Navarra M, Bianchi G
Arch Ital Urol Androl 2017 Oct 3;89(3):197-202. doi: 10.4081/aiua.2017.3.197. PMID: 28969404
A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia.
Gann PH, Deaton RJ, Rueter EE, van Breemen RB, Nonn L, Macias V, Han M, Ananthanarayanan V
Nutr Cancer 2015;67(7):1104-12. doi: 10.1080/01635581.2015.1075560. PMID: 26422197Free PMC Article
Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy.
Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA
Expert Opin Investig Drugs 2006 Mar;15(3):293-305. doi: 10.1517/13543784.15.3.293. PMID: 16503765
Phase IIA clinical trial to test the efficacy and safety of Toremifene in men with high-grade prostatic intraepithelial neoplasia.
Steiner MS, Pound CR
Clin Prostate Cancer 2003 Jun;2(1):24-31. doi: 10.3816/cgc.2003.n.009. PMID: 15046680
Prostatic intraepithelial neoplasia (PIN) and other prostatic lesions as risk factors and surrogate endpoints for cancer chemoprevention trials.
Bostwick DG, Aquilina JW
J Cell Biochem Suppl 1996;25:156-64. PMID: 9027613

Prognosis

African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.
Siddappa M, Hussain S, Wani SA, White J, Tang H, Gray JS, Jafari H, Wu HC, Long MD, Elhussin I, Karanam B, Wang H, Morgan R, Hardiman G, Adelani IB, Rotimi SO, Murphy AR, Nonn L, Davis MB, Kittles RA, Hughes Halbert C, Sucheston-Campbell LE, Yates C, Campbell MJ
Cancer Res Commun 2023 Apr;3(4):621-639. Epub 2023 Apr 18 doi: 10.1158/2767-9764.CRC-22-0389. PMID: 37082578Free PMC Article
Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial.
Micali S, Territo A, Pirola GM, Ferrari N, Sighinolfi MC, Martorana E, Navarra M, Bianchi G
Arch Ital Urol Androl 2017 Oct 3;89(3):197-202. doi: 10.4081/aiua.2017.3.197. PMID: 28969404
High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer.
Willems-Jones A, Kavanagh L, Clouston D, Bolton D; kConFab Investigators, Fox S, Thorne H
BJU Int 2012 Dec;110(11 Pt C):E1181-6. Epub 2012 Oct 4 doi: 10.1111/j.1464-410X.2012.11519.x. PMID: 23035815
Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer.
Yee DS, Narula N, Ramzy I, Boker J, Ahlering TE, Skarecky DW, Ornstein DK
Arch Pathol Lab Med 2007 Jun;131(6):902-8. doi: 10.5858/2007-131-902-RAIPEI. PMID: 17550317
Prostatic intraepithelial neoplasia and apoptosis in benign prostatic hyperplasia before and after the Chernobyl accident in Ukraine.
Vosianov AF, Romanenko AM, Zabarko LB, Szende B, Wang CY, Landas S, Haas GP
Pathol Oncol Res 1999;5(1):28-31. doi: 10.1053/paor.1999.0028. PMID: 10079374

Clinical prediction guides

African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A.
Siddappa M, Hussain S, Wani SA, White J, Tang H, Gray JS, Jafari H, Wu HC, Long MD, Elhussin I, Karanam B, Wang H, Morgan R, Hardiman G, Adelani IB, Rotimi SO, Murphy AR, Nonn L, Davis MB, Kittles RA, Hughes Halbert C, Sucheston-Campbell LE, Yates C, Campbell MJ
Cancer Res Commun 2023 Apr;3(4):621-639. Epub 2023 Apr 18 doi: 10.1158/2767-9764.CRC-22-0389. PMID: 37082578Free PMC Article
Effect of green tea catechins in patients with high-grade prostatic intraepithelial neoplasia: Results of a short-term double-blind placebo controlled phase II clinical trial.
Micali S, Territo A, Pirola GM, Ferrari N, Sighinolfi MC, Martorana E, Navarra M, Bianchi G
Arch Ital Urol Androl 2017 Oct 3;89(3):197-202. doi: 10.4081/aiua.2017.3.197. PMID: 28969404
High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer.
Willems-Jones A, Kavanagh L, Clouston D, Bolton D; kConFab Investigators, Fox S, Thorne H
BJU Int 2012 Dec;110(11 Pt C):E1181-6. Epub 2012 Oct 4 doi: 10.1111/j.1464-410X.2012.11519.x. PMID: 23035815
Comparison of annexin II, p63 and alpha-methylacyl-CoA racemase immunoreactivity in prostatic tissue: a tissue microarray study.
Stewart J, Fleshner N, Cole H, Sweet J
J Clin Pathol 2007 Jul;60(7):773-80. Epub 2006 Aug 17 doi: 10.1136/jcp.2006.040808. PMID: 16916997Free PMC Article
Prostatic intraepithelial neoplasia in genetically engineered mice.
Park JH, Walls JE, Galvez JJ, Kim M, Abate-Shen C, Shen MM, Cardiff RD
Am J Pathol 2002 Aug;161(2):727-35. doi: 10.1016/S0002-9440(10)64228-9. PMID: 12163397Free PMC Article

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