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Intracranial Melanoma

MedGen UID:
232664
•Concept ID:
C1334243
•
Neoplastic Process

Definition

A melanoma that arises from the structures within the cranium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntracranial Melanoma

Professional guidelines

PubMed

Microsurgery for the treatment of primary malignant intracranial melanoma: a surgical series and literature review.
Wang J, Guo ZZ, Wang YJ, Zhang SG, Xing DG
Eur J Surg Oncol 2014 Sep;40(9):1062-71. Epub 2013 Dec 14 doi: 10.1016/j.ejso.2013.11.024. PMID: 24360613
Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases.
Selek U, Chang EL, Hassenbusch SJ 3rd, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH
Int J Radiat Oncol Biol Phys 2004 Jul 15;59(4):1097-106. doi: 10.1016/j.ijrobp.2003.12.037. PMID: 15234044
Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant.
Randazzo BP, Bhat MG, Kesari S, Fraser NW, Brown SM
J Invest Dermatol 1997 Jun;108(6):933-7. doi: 10.1111/1523-1747.ep12295238. PMID: 9182825

Recent clinical studies

Etiology

UVEAL MELANOMA PRESENTING AS HEPATIC METASTASIS IN A PATIENT WITH OCULODERMAL MELANOCYTOSIS.
Evans WI, Wilson MW, Bahrami A, Pappo AS, Hoehn ME
Retin Cases Brief Rep 2023 Jul 1;17(4):403-405. doi: 10.1097/ICB.0000000000001205. PMID: 37364199
Correlation of MRI signal characteristics of intracranial melanoma metastases with BRAF mutation status.
Lasocki A, McArthur GA
Melanoma Res 2022 Oct 1;32(5):373-378. Epub 2022 Aug 17 doi: 10.1097/CMR.0000000000000847. PMID: 35979667
Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases.
Fischer GM, Jalali A, Kircher DA, Lee WC, McQuade JL, Haydu LE, Joon AY, Reuben A, de Macedo MP, Carapeto FCL, Yang C, Srivastava A, Ambati CR, Sreekumar A, Hudgens CW, Knighton B, Deng W, Ferguson SD, Tawbi HA, Glitza IC, Gershenwald JE, Vashisht Gopal YN, Hwu P, Huse JT, Wargo JA, Futreal PA, Putluri N, Lazar AJ, DeBerardinis RJ, Marszalek JR, Zhang J, Holmen SL, Tetzlaff MT, Davies MA
Cancer Discov 2019 May;9(5):628-645. Epub 2019 Feb 20 doi: 10.1158/2159-8290.CD-18-1489. PMID: 30787016Free PMC Article
Microsurgery for the treatment of primary malignant intracranial melanoma: a surgical series and literature review.
Wang J, Guo ZZ, Wang YJ, Zhang SG, Xing DG
Eur J Surg Oncol 2014 Sep;40(9):1062-71. Epub 2013 Dec 14 doi: 10.1016/j.ejso.2013.11.024. PMID: 24360613
Intracranial melanoma metastases: surgical treatment and follow-up of 18 patients.
Neuss M, König A, Herrmann HD
Anticancer Res 1987 May-Jun;7(3 Pt B):445-6. PMID: 3631902

Diagnosis

Primary intracranial melanoma, amelanotic variant: Case report.
Andrés Sanz JA, Ruiz Ginés JA, Iliev H, Aguas Valiente J
Neurocirugia (Astur : Engl Ed) 2022 Nov-Dec;33(6):383-388. Epub 2022 Mar 2 doi: 10.1016/j.neucie.2022.02.005. PMID: 35248502
Microsurgery for the treatment of primary malignant intracranial melanoma: a surgical series and literature review.
Wang J, Guo ZZ, Wang YJ, Zhang SG, Xing DG
Eur J Surg Oncol 2014 Sep;40(9):1062-71. Epub 2013 Dec 14 doi: 10.1016/j.ejso.2013.11.024. PMID: 24360613
Absent response of intracranial melanoma metastases harboring BRAF V600E sequence variation to vemurafenib.
D'Alonzo D, Glatz K
Mayo Clin Proc 2013 Dec;88(12):e151-2. doi: 10.1016/j.mayocp.2013.04.033. PMID: 24290130
Primary intracranial malignant melanoma.
Shah I, Imran M, Akram R, Rafat S, Zia K, Emaduddin M
J Coll Physicians Surg Pak 2013 Feb;23(2):157-9. PMID: 23374525
Nevus of Ota in children.
Sinha S, Cohen PJ, Schwartz RA
Cutis 2008 Jul;82(1):25-9. PMID: 18712021

Therapy

T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels.
Messmer JM, Thommek C, Piechutta M, Venkataramani V, Wehner R, Westphal D, Schubert M, Mayer CD, Effern M, Berghoff AS, Hinze D, Helfrich I, Schadendorf D, Wick W, Hölzel M, Karreman MA, Winkler F
Immunity 2024 Nov 12;57(11):2688-2703.e11. Epub 2024 Oct 4 doi: 10.1016/j.immuni.2024.09.003. PMID: 39368486
Nivolumab therapy for a pediatric-onset primary intracranial melanoma.
Oba U, Koga Y, Hata N, Oda Y, Ohga S
Pediatr Int 2022 Jan;64(1):e14956. doi: 10.1111/ped.14956. PMID: 35484924
Purely Meningeal Intracranial Relapse of Melanoma Brain Metastases After Surgical Resection and Immunotherapy as a Unique Disease Progression Pattern: Our Experience and Review of the Literature.
Armocida D, Marzetti F, Pesce A, Caporlingua A, D'Angelo L, Santoro A
World Neurosurg 2020 Feb;134:150-154. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.101. PMID: 31751613
Absent response of intracranial melanoma metastases harboring BRAF V600E sequence variation to vemurafenib.
D'Alonzo D, Glatz K
Mayo Clin Proc 2013 Dec;88(12):e151-2. doi: 10.1016/j.mayocp.2013.04.033. PMID: 24290130
Multiple intracranial melanoma metastases: case report and review of the literature.
Guzel A, Maciaczyk J, Dohmen-Scheufler H, Senturk S, Volk B, Ostertag CB, Nikkhah G
J Neurooncol 2009 Jul;93(3):413-20. Epub 2009 Feb 1 doi: 10.1007/s11060-008-9785-0. PMID: 19184642

Prognosis

The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis.
Huo J, Wang Y, Zhang Y, Wang W, Yang P, Zhao W, Zhang M, Cui L, Zhang D
Anticancer Agents Med Chem 2022;22(1):152-159. doi: 10.2174/1871520621666210322092906. PMID: 34225636
Microsurgery for the treatment of primary malignant intracranial melanoma: a surgical series and literature review.
Wang J, Guo ZZ, Wang YJ, Zhang SG, Xing DG
Eur J Surg Oncol 2014 Sep;40(9):1062-71. Epub 2013 Dec 14 doi: 10.1016/j.ejso.2013.11.024. PMID: 24360613
Absent response of intracranial melanoma metastases harboring BRAF V600E sequence variation to vemurafenib.
D'Alonzo D, Glatz K
Mayo Clin Proc 2013 Dec;88(12):e151-2. doi: 10.1016/j.mayocp.2013.04.033. PMID: 24290130
Primary intracranial melanoma in a child with a giant congenital melanocytic naevus and normal MRI.
Al-Hadithy N, Al-Nakib K, McGurk S, Quaba A
BMJ Case Rep 2013 Apr 29;2013 doi: 10.1136/bcr-2013-009276. PMID: 23632186Free PMC Article
Intracranial melanoma metastases: surgical treatment and follow-up of 18 patients.
Neuss M, König A, Herrmann HD
Anticancer Res 1987 May-Jun;7(3 Pt B):445-6. PMID: 3631902

Clinical prediction guides

The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis.
Huo J, Wang Y, Zhang Y, Wang W, Yang P, Zhao W, Zhang M, Cui L, Zhang D
Anticancer Agents Med Chem 2022;22(1):152-159. doi: 10.2174/1871520621666210322092906. PMID: 34225636
Cost-Effectiveness of Subsequent Whole-Brain Radiotherapy or Hippocampal-Avoidant Whole-Brain Radiotherapy Versus Stereotactic Radiosurgery or Surgery Alone for Treatment of Melanoma Brain Metastases.
Tran AD, Fogarty G, Nowak AK, Diaby V, Hong A, Watts C, Morton RL
Appl Health Econ Health Policy 2020 Oct;18(5):679-687. doi: 10.1007/s40258-020-00560-1. PMID: 32157631
Are prognostic indices for brain metastases of melanoma still valid in the stereotactic era?
Badakhshi H, Engeling F, Budach V, Ghadjar P, Zschaeck S, Kaul D
Radiat Oncol 2018 Jan 10;13(1):3. doi: 10.1186/s13014-017-0951-4. PMID: 29316943Free PMC Article
A Retrospective Evaluation of Vemurafenib as Treatment for BRAF-Mutant Melanoma Brain Metastases.
Harding JJ, Catalanotti F, Munhoz RR, Cheng DT, Yaqubie A, Kelly N, McDermott GC, Kersellius R, Merghoub T, Lacouture ME, Carvajal RD, Panageas KS, Berger MF, Rosen N, Solit DB, Chapman PB
Oncologist 2015 Jul;20(7):789-97. Epub 2015 May 8 doi: 10.1634/theoncologist.2014-0012. PMID: 25956405Free PMC Article
Vesicular stomatitis virus variants selectively infect and kill human melanomas but not normal melanocytes.
Wollmann G, Davis JN, Bosenberg MW, van den Pol AN
J Virol 2013 Jun;87(12):6644-59. Epub 2013 Apr 3 doi: 10.1128/JVI.03311-12. PMID: 23552414Free PMC Article

Recent systematic reviews

Management and prognosis of primary cerebral melanocytic tumors. A case report and systematic review.
Splavski B, Muzevic D, Kovacevic M, Splavski B Jr, Bajek G
J Neurol Surg A Cent Eur Neurosurg 2015 Mar;76(2):144-8. Epub 2014 Jul 21 doi: 10.1055/s-0034-1371514. PMID: 25045860

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