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Tenosynovial giant cell tumor

MedGen UID:
232927
•Concept ID:
C1318543
•
Neoplastic Process
Synonyms: Fibrous Histiocytoma of Tendon Sheath; Giant Cell Tumor of Tendon Sheath; Tenosynovial Giant Cell Tumor
SNOMED CT: Giant cell tumor of tendon sheath (95413004); Fibrous histiocytoma of tendon sheath (128777004); Fibrous histiocytoma of tendon sheath (310605004); Benign tenosynovial giant cell tumor (128777004); Benign giant cell tumor of tendon sheath (128777004)
 
Monarch Initiative: MONDO:0002522

Definition

A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse. [from NCI]

Professional guidelines

PubMed

CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.
Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744
Treatment updates on tenosynovial giant cell tumor.
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703
Management of Pigmented Villonodular Synovitis (PVNS): an Orthopedic Surgeon's Perspective.
Bernthal NM, Ishmael CR, Burke ZDC
Curr Oncol Rep 2020 Jun 4;22(6):63. doi: 10.1007/s11912-020-00926-7. PMID: 32494892

Recent clinical studies

Etiology

Outcomes of Tenosynovial Giant Cell Tumor of the Foot and Ankle.
Barnett JR, Rudran B, Khan A, O'Reilly-Harbidge S, Patel S, Malhotra K, Cullen N, Welck M, Aston W
Foot Ankle Int 2023 Oct;44(10):1013-1020. Epub 2023 Aug 30 doi: 10.1177/10711007231189491. PMID: 37644900
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Prospects of Treating Tenosynovial Giant Cell Tumor through Pexidartinib: A Review.
Alsayadi YMMA, Chawla PA
Anticancer Agents Med Chem 2021;21(12):1510-1519. doi: 10.2174/1871520620999201102123555. PMID: 33143617
Bilateral tenosynovial giant cell tumor of the knee accompanied by chronic ACL tear.
Cho HJ, Lee SH, Han SB, Lee DK, Kim CH, Lee DH
J Orthop Sci 2012 Jan;17(1):93-7. Epub 2011 May 18 doi: 10.1007/s00776-011-0076-9. PMID: 21590297
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy.
Vardakas DG, Musgrave DS, Goebel F, Sotereanos DG
Am J Orthop (Belle Mead NJ) 2004 Mar;33(3):137-40. PMID: 15074461

Diagnosis

Calcified Chondroid Mesenchymal Neoplasms.
Kao EY, Chen EY
Surg Pathol Clin 2024 Mar;17(1):77-82. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.006. PMID: 38278609
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Concomitant Spondyloarthritis and Tenosynovial Giant Cell Tumor in Pigmented Villonodular Synovitis Challenging Cases.
Manetti M, Mondanelli N, Rosa I, Ibba-Manneschi L, Benucci M, Bandinelli F
J Clin Rheumatol 2020 Aug;26(5):e115-e117. doi: 10.1097/RHU.0000000000000985. PMID: 30601200
Pigmented villonodular synovitis.
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions.
Rubin BP
Skeletal Radiol 2007 Apr;36(4):267-8. doi: 10.1007/s00256-006-0249-3. PMID: 17225151

Therapy

CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment.
Wen J, Wang S, Guo R, Liu D
Eur J Med Chem 2023 Jan 5;245(Pt 1):114884. Epub 2022 Oct 29 doi: 10.1016/j.ejmech.2022.114884. PMID: 36335744
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
Treatment updates on tenosynovial giant cell tumor.
Palmerini E, Staals EL
Curr Opin Oncol 2022 Jul 1;34(4):322-327. doi: 10.1097/CCO.0000000000000853. PMID: 35837703
Pexidartinib: First Approval.
Lamb YN
Drugs 2019 Nov;79(16):1805-1812. doi: 10.1007/s40265-019-01210-0. PMID: 31602563Free PMC Article
Pigmented villonodular synovitis.
Fałek A, Niemunis-Sawicka J, Wrona K, Szczypiór G, Rzepecka-Wejs L, Cięszczyk K, Burdan M, Puderecki M, Burzec P, Marzec-Kotarska B, Szumiło J, Burdan F
Folia Med Cracov 2018;58(4):93-104. PMID: 30745604

Prognosis

Updates on the Treatment of Tenosynovial Giant Cell Tumor.
Chan AS, Katiyar V, Dy P, Singh V
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):307-315. doi: 10.56875/2589-0646.1032. PMID: 37363972
Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment.
Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH
Mol Cancer Ther 2021 Aug;20(8):1388-1399. Epub 2021 Jun 4 doi: 10.1158/1535-7163.MCT-20-0591. PMID: 34088832Free PMC Article
Locally Aggressive Connective Tissue Tumors.
Gounder MM, Thomas DM, Tap WD
J Clin Oncol 2018 Jan 10;36(2):202-209. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.75.8482. PMID: 29220303Free PMC Article
A large, multiply recurrent tenosynovial giant cell tumor of the hand treated with resection and radiation therapy.
Vardakas DG, Musgrave DS, Goebel F, Sotereanos DG
Am J Orthop (Belle Mead NJ) 2004 Mar;33(3):137-40. PMID: 15074461

Clinical prediction guides

Active surveillance of diffuse-type tenosynovial giant cell tumors: A retrospective, multicenter cohort study.
Spierenburg G, Staals EL, Palmerini E, Randall RL, Thorpe SW, Wunder JS, Ferguson PC, Verspoor FGM, Houdek MT, Bernthal NM, Schreuder BHWB, Gelderblom H, van de Sande MAJ, van der Heijden L
Eur J Surg Oncol 2024 Feb;50(2):107953. Epub 2024 Jan 6 doi: 10.1016/j.ejso.2024.107953. PMID: 38215550
Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.
Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Optimal Treatment for Tenosynovial Giant Cell Tumor of the Hand.
Kitagawa Y, Takai S
J Nippon Med Sch 2020 Sep 9;87(4):184-190. Epub 2020 Apr 30 doi: 10.1272/jnms.JNMS.2020_87-408. PMID: 32350187
Tenosynovial giant cell tumor in the foot and ankle.
Çevik HB, Kayahan S, Eceviz E, Gümüştaş SA
Foot Ankle Surg 2020 Aug;26(6):712-716. Epub 2019 Sep 6 doi: 10.1016/j.fas.2019.08.014. PMID: 31526689
Pigmented villonodular synovitis occurring in the temporomandibular joint.
Nomura F, Ariizumi Y, Kiyokawa Y, Tasaki A, Tateishi Y, Koide N, Kawabe H, Sugawara T, Tanaka K, Asakage T
Auris Nasus Larynx 2019 Aug;46(4):609-617. Epub 2018 Nov 27 doi: 10.1016/j.anl.2018.10.021. PMID: 30497770

Recent systematic reviews

Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.
Robert M, Farese H, Miossec P
Front Immunol 2022;13:820046. Epub 2022 Feb 21 doi: 10.3389/fimmu.2022.820046. PMID: 35265077Free PMC Article
Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis.
Siegel M, Bode L, Südkamp N, Kühle J, Zwingmann J, Schmal H, Herget GW
PLoS One 2021;16(12):e0260795. Epub 2021 Dec 2 doi: 10.1371/journal.pone.0260795. PMID: 34855875Free PMC Article
Spinal pigmented villonodular synovitis and tenosynovial giant cell tumor: A report of two cases and a comprehensive systematic review.
Zeoli T, Mathkour M, Scullen T, Carr C, Abou-Al-Shaar H, Wang L, Divagaran A, Dindial R, Tubbs RS, Bui CJ, Maulucci CM
Clin Neurol Neurosurg 2021 Mar;202:106489. Epub 2021 Jan 12 doi: 10.1016/j.clineuro.2021.106489. PMID: 33596487
Management of Tenosynovial Giant Cell Tumor: A Neoplastic and Inflammatory Disease.
Healey JH, Bernthal NM, van de Sande M
J Am Acad Orthop Surg Glob Res Rev 2020 Nov;4(11):e20.00028. doi: 10.5435/JAAOSGlobal-D-20-00028. PMID: 33156160Free PMC Article
Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development.
Benner B, Good L, Quiroga D, Schultz TE, Kassem M, Carson WE, Cherian MA, Sardesai S, Wesolowski R
Drug Des Devel Ther 2020;14:1693-1704. Epub 2020 May 4 doi: 10.2147/DDDT.S253232. PMID: 32440095Free PMC Article

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