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Scrotum melanoma

MedGen UID:
233100
•Concept ID:
C1331544
•
Neoplastic Process
Synonyms: melanoma (disease) of scrotum; Melanoma of Scrotum; melanoma of scrotum; Melanoma of the Scrotum; melanoma of the scrotum; Scrotal Melanoma; scrotal melanoma; scrotum melanoma; scrotum melanoma (disease)
 
Monarch Initiative: MONDO:0001652

Definition

A melanoma arising from the scrotum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVScrotum melanoma

Professional guidelines

PubMed

A systematic review of basal cell carcinoma on the scrotum-reviewing presentation and identifying challenges in management.
Demirci MA, Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 May 25;316(6):255. doi: 10.1007/s00403-024-03058-1. PMID: 38795216
Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment.
Baumgartner J, Šimaljaková M
J Cosmet Laser Ther 2017 Dec;19(8):459-464. Epub 2017 Jun 30 doi: 10.1080/14764172.2017.1343953. PMID: 28665237
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439

Recent clinical studies

Etiology

Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment.
Baumgartner J, Šimaljaková M
J Cosmet Laser Ther 2017 Dec;19(8):459-464. Epub 2017 Jun 30 doi: 10.1080/14764172.2017.1343953. PMID: 28665237
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Efficacy and safety of topical ALA-PDT in the treatment of EMPD.
Gao Y, Zhang XC, Wang WS, Yang Y, Wang HL, Lu YG, Fan DL
Photodiagnosis Photodyn Ther 2015 Mar;12(1):92-7. Epub 2014 Dec 3 doi: 10.1016/j.pdpdt.2014.11.004. PMID: 25479094
Melanoma of the penis, scrotum and male urethra: a 40-year single institution experience.
Sánchez-Ortiz R, Huang SF, Tamboli P, Prieto VG, Hester G, Pettaway CA
J Urol 2005 Jun;173(6):1958-65. doi: 10.1097/01.ju.0000159207.91737.53. PMID: 15879790
Cancer incidence in England and Wales and New Zealand and in migrants between the two countries.
Swerdlow AJ, Cooke KR, Skegg DC, Wilkinson J
Br J Cancer 1995 Jul;72(1):236-43. doi: 10.1038/bjc.1995.309. PMID: 7599059Free PMC Article

Diagnosis

TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Genital premalignant and malignant diseases: a retrospective study of male genital skin biopsies.
Mazzoni D, Winkle D, Pool L, Hall A, Muir J
Int J Dermatol 2021 Jun;60(6):712-716. Epub 2021 Feb 27 doi: 10.1111/ijd.15439. PMID: 33638458
Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes.
Zikry J, Chapman LW, Korta DZ, Smith J
Dermatol Surg 2017 Jun;43(6):765-770. doi: 10.1097/DSS.0000000000001072. PMID: 28291064
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Cutaneous scrotal metastasis: origins and clinical characteristics of visceral malignancies that metastasize to the scrotum.
Hoyt BS, Cohen PR
Int J Dermatol 2013 Apr;52(4):398-403; quiz 403-5. Epub 2013 Jan 20 doi: 10.1111/j.1365-4632.2012.05717.x. PMID: 23331276

Therapy

Oncogene targeted therapy for metastatic primary scrotal melanoma.
Stocks B, Fuentes H, McDowell Z, Brooks M, Jones JA
Can J Urol 2021 Apr;28(2):10643-10647. PMID: 33872566
Primary scrotal melanoma: it is time to destigmatize genital lesions.
Özkur E, Altunay İK
An Bras Dermatol 2019 Nov-Dec;94(6):721-723. Epub 2019 Nov 2 doi: 10.1016/j.abd.2018.12.005. PMID: 31789252Free PMC Article
Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment.
Baumgartner J, Šimaljaková M
J Cosmet Laser Ther 2017 Dec;19(8):459-464. Epub 2017 Jun 30 doi: 10.1080/14764172.2017.1343953. PMID: 28665237
Efficacy and safety of topical ALA-PDT in the treatment of EMPD.
Gao Y, Zhang XC, Wang WS, Yang Y, Wang HL, Lu YG, Fan DL
Photodiagnosis Photodyn Ther 2015 Mar;12(1):92-7. Epub 2014 Dec 3 doi: 10.1016/j.pdpdt.2014.11.004. PMID: 25479094
Metalworking fluids and malignant melanoma in autoworkers.
Costello S, Friesen MC, Christiani DC, Eisen EA
Epidemiology 2011 Jan;22(1):90-7. doi: 10.1097/EDE.0b013e3181fce4b8. PMID: 20975563

Prognosis

Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes.
Zikry J, Chapman LW, Korta DZ, Smith J
Dermatol Surg 2017 Jun;43(6):765-770. doi: 10.1097/DSS.0000000000001072. PMID: 28291064
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Cutaneous scrotal metastasis: origins and clinical characteristics of visceral malignancies that metastasize to the scrotum.
Hoyt BS, Cohen PR
Int J Dermatol 2013 Apr;52(4):398-403; quiz 403-5. Epub 2013 Jan 20 doi: 10.1111/j.1365-4632.2012.05717.x. PMID: 23331276
Palliation of male genital cancers.
Shukla CJ, Shabbir M, Feneley MR, Withey S, Muneer A, Minhas S
Clin Oncol (R Coll Radiol) 2010 Nov;22(9):747-54. Epub 2010 Aug 25 doi: 10.1016/j.clon.2010.07.010. PMID: 20800458

Clinical prediction guides

TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment.
Baumgartner J, Šimaljaková M
J Cosmet Laser Ther 2017 Dec;19(8):459-464. Epub 2017 Jun 30 doi: 10.1080/14764172.2017.1343953. PMID: 28665237
Vitamin D receptor immunohistochemistry variability in sun-exposed and non-sun-exposed melanomas.
Paolino G, Panetta C, Cota C, Didona D, Moliterni E, Di Mattia C, De Vita G, Bottoni U, Donati P, Calvieri S
Melanoma Res 2017 Feb;27(1):17-23. doi: 10.1097/CMR.0000000000000311. PMID: 27792059
Malignant mesothelioma of testicular tunica vaginalis.
Abe K, Kato N, Miki K, Nimura S, Suzuki M, Kiyota H, Onodera S, Oishi Y
Int J Urol 2002 Oct;9(10):602-3. doi: 10.1046/j.1442-2042.2002.00521.x. PMID: 12445242
The conversion of testosterone to 5 alpha-androstan-17 beta-ol-3-one (dihydrotestosterone) by skin slices of man.
Wilson JD, Walker JD
J Clin Invest 1969 Feb;48(2):371-9. doi: 10.1172/JCI105994. PMID: 5249746Free PMC Article

Recent systematic reviews

A systematic review of basal cell carcinoma on the scrotum-reviewing presentation and identifying challenges in management.
Demirci MA, Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 May 25;316(6):255. doi: 10.1007/s00403-024-03058-1. PMID: 38795216
Systematic Review of Surgical Treatment and Outcomes After Local Surgery of Primary Cutaneous Melanomas of the Penis and Scrotum.
Bittar JM, Bittar PG, Wan MT, Kovell RC, Guzzo TJ, Shin TM, Etzkorn JR, Sobanko JF, Miller CJ
Dermatol Surg 2018 Sep;44(9):1159-1169. doi: 10.1097/DSS.0000000000001579. PMID: 29985865
Scrotal Melanoma: A Systematic Review of Presentation, Treatment, and Outcomes.
Zikry J, Chapman LW, Korta DZ, Smith J
Dermatol Surg 2017 Jun;43(6):765-770. doi: 10.1097/DSS.0000000000001072. PMID: 28291064

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