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Metastatic Neuroendocrine Tumor

MedGen UID:
233180
•Concept ID:
C1334715
•
Neoplastic Process
Synonyms: Metastatic neuroendocrine tumor; Metastatic Well Differentiated Neuroendocrine Neoplasm; Metastatic well-differentiated neuroendocrine tumor
SNOMED CT: Metastatic neuroendocrine tumor (1290057000); Metastatic well-differentiated neuroendocrine tumor (1290057000); Metastatic well-differentiated neuroendocrine tumor (1290060007); Metastatic neuroendocrine tumor (1290060007)

Definition

A neuroendocrine tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Neuroendocrine Tumor

Professional guidelines

PubMed

A Real-World, Population-Based Study for the Incidence and Outcomes of Neuroendocrine Neoplasms of Unknown Primary.
Abdel-Rahman O
Neuroendocrinology 2021;111(9):876-882. Epub 2020 Sep 25 doi: 10.1159/000511812. PMID: 32980845
Telotristat ethyl: proof of principle and the first oral agent in the management of well-differentiated metastatic neuroendocrine tumor and carcinoid syndrome diarrhea.
Masab M, Saif MW
Cancer Chemother Pharmacol 2017 Dec;80(6):1055-1062. Epub 2017 Oct 19 doi: 10.1007/s00280-017-3462-y. PMID: 29051994
Long-Term Hepatotoxicity of Yttrium-90 Radioembolization as Treatment of Metastatic Neuroendocrine Tumor to the Liver.
Su YK, Mackey RV, Riaz A, Gates VL, Benson AB 3rd, Miller FH, Yaghmai V, Gabr A, Salem R, Lewandowski RJ
J Vasc Interv Radiol 2017 Nov;28(11):1520-1526. Epub 2017 Jun 30 doi: 10.1016/j.jvir.2017.05.011. PMID: 28673658

Recent clinical studies

Etiology

Elderly Patients with Metastatic Neuroendocrine Tumors Are Undertreated and Have Shorter Survival: The LyREMeNET Study.
Lemelin A, Maucort-Boulch D, Castel-Kremer E, Forestier J, Hervieu V, Lorcet M, Boutitie F, Theillaumas A, Robinson P, Duclos A, Lombard-Bohas C, Walter T
Neuroendocrinology 2020;110(7-8):653-661. Epub 2019 Oct 7 doi: 10.1159/000503901. PMID: 31586998
Systematic Review and Meta-Analysis on the Role of Chemotherapy in Advanced and Metastatic Neuroendocrine Tumor (NET).
Wong MH, Chan DL, Lee A, Li BT, Lumba S, Clarke SJ, Samra J, Pavlakis N
PLoS One 2016;11(6):e0158140. Epub 2016 Jun 30 doi: 10.1371/journal.pone.0158140. PMID: 27362760Free PMC Article
Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables.
Sher LS, Levi DM, Wecsler JS, Lo M, Petrovic LM, Groshen S, Ji L, Uso TD, Tector AJ, Hamilton AS, Marsh JW, Schwartz ME
J Surg Oncol 2015 Aug;112(2):125-32. Epub 2015 Jul 14 doi: 10.1002/jso.23973. PMID: 26171686Free PMC Article
Liver transplantation and pancreatic resection: a single-center experience and a review of the literature.
Stauffer JA, Steers JL, Bonatti H, Dougherty MK, Aranda-Michel J, Dickson RC, Harnois DM, Nguyen JH
Liver Transpl 2009 Dec;15(12):1728-37. doi: 10.1002/lt.21932. PMID: 19938125
Liver transplant for metastatic neuroendocrine tumor.
Alsina AE, Bartus S, Hull D, Rosson R, Schweizer RT
J Clin Gastroenterol 1990 Oct;12(5):533-7. doi: 10.1097/00004836-199010000-00009. PMID: 1699994

Diagnosis

Elderly Patients with Metastatic Neuroendocrine Tumors Are Undertreated and Have Shorter Survival: The LyREMeNET Study.
Lemelin A, Maucort-Boulch D, Castel-Kremer E, Forestier J, Hervieu V, Lorcet M, Boutitie F, Theillaumas A, Robinson P, Duclos A, Lombard-Bohas C, Walter T
Neuroendocrinology 2020;110(7-8):653-661. Epub 2019 Oct 7 doi: 10.1159/000503901. PMID: 31586998
Neuroendocrine Tumors of the Breast.
Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945
Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables.
Sher LS, Levi DM, Wecsler JS, Lo M, Petrovic LM, Groshen S, Ji L, Uso TD, Tector AJ, Hamilton AS, Marsh JW, Schwartz ME
J Surg Oncol 2015 Aug;112(2):125-32. Epub 2015 Jul 14 doi: 10.1002/jso.23973. PMID: 26171686Free PMC Article
Metastatic neuroendocrine tumor found on screening mammogram.
Amin AL, Kong AL
WMJ 2011 Jun;110(3):140-3; quiz 145. PMID: 21749000
Unusual case of metastatic neuroendocrine tumor.
Manahan MA, Dackiw AP, Ball DW, Zeiger MA
Endocr Pract 2007 Jan-Feb;13(1):72-6. doi: 10.4158/EP.13.1.72. PMID: 17360306

Therapy

Updates and Expert Opinions on Liver Transplantation for Gastrointestinal Malignancies.
Shannon AH, Ruff SM, Schenk AD, Washburn K, Pawlik TM
Medicina (Kaunas) 2023 Jul 13;59(7) doi: 10.3390/medicina59071290. PMID: 37512101Free PMC Article
The safety of lanreotide for neuroendocrine tumor.
Godara A, Siddiqui NS, Byrne MM, Saif MW
Expert Opin Drug Saf 2019 Jan;18(1):1-10. Epub 2018 Dec 24 doi: 10.1080/14740338.2019.1559294. PMID: 30582380
Telotristat ethyl: proof of principle and the first oral agent in the management of well-differentiated metastatic neuroendocrine tumor and carcinoid syndrome diarrhea.
Masab M, Saif MW
Cancer Chemother Pharmacol 2017 Dec;80(6):1055-1062. Epub 2017 Oct 19 doi: 10.1007/s00280-017-3462-y. PMID: 29051994
Liver transplantation and pancreatic resection: a single-center experience and a review of the literature.
Stauffer JA, Steers JL, Bonatti H, Dougherty MK, Aranda-Michel J, Dickson RC, Harnois DM, Nguyen JH
Liver Transpl 2009 Dec;15(12):1728-37. doi: 10.1002/lt.21932. PMID: 19938125
Gemcitabine and oxaliplatin combination chemotherapy for metastatic well-differentiated neuroendocrine carcinomas: a single-center experience.
Cassier PA, Walter T, Eymard B, Ardisson P, Perol M, Paillet C, Chayvialle JA, Scoazec JY, Hervieu V, Bohas CL
Cancer 2009 Aug 1;115(15):3392-9. doi: 10.1002/cncr.24384. PMID: 19472402

Prognosis

Elderly Patients with Metastatic Neuroendocrine Tumors Are Undertreated and Have Shorter Survival: The LyREMeNET Study.
Lemelin A, Maucort-Boulch D, Castel-Kremer E, Forestier J, Hervieu V, Lorcet M, Boutitie F, Theillaumas A, Robinson P, Duclos A, Lombard-Bohas C, Walter T
Neuroendocrinology 2020;110(7-8):653-661. Epub 2019 Oct 7 doi: 10.1159/000503901. PMID: 31586998
The safety of lanreotide for neuroendocrine tumor.
Godara A, Siddiqui NS, Byrne MM, Saif MW
Expert Opin Drug Saf 2019 Jan;18(1):1-10. Epub 2018 Dec 24 doi: 10.1080/14740338.2019.1559294. PMID: 30582380
Neuroendocrine Tumors of the Breast.
Rosen LE, Gattuso P
Arch Pathol Lab Med 2017 Nov;141(11):1577-1581. doi: 10.5858/arpa.2016-0364-RS. PMID: 29072945
Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables.
Sher LS, Levi DM, Wecsler JS, Lo M, Petrovic LM, Groshen S, Ji L, Uso TD, Tector AJ, Hamilton AS, Marsh JW, Schwartz ME
J Surg Oncol 2015 Aug;112(2):125-32. Epub 2015 Jul 14 doi: 10.1002/jso.23973. PMID: 26171686Free PMC Article
Liver transplantation for metastatic neuroendocrine tumor: a case report and review of the literature.
Blonski WC, Reddy KR, Shaked A, Siegelman E, Metz DC
World J Gastroenterol 2005 Dec 28;11(48):7676-83. doi: 10.3748/wjg.v11.i48.7676. PMID: 16437698Free PMC Article

Clinical prediction guides

Post-PRRT scans: which scans to make and what to look for.
Aalbersberg EA, de Vries-Huizing DMV, Tesselaar MET, Stokkel MPM, Versleijen MWJ
Cancer Imaging 2022 Jun 17;22(1):29. doi: 10.1186/s40644-022-00467-1. PMID: 35715867Free PMC Article
The safety of lanreotide for neuroendocrine tumor.
Godara A, Siddiqui NS, Byrne MM, Saif MW
Expert Opin Drug Saf 2019 Jan;18(1):1-10. Epub 2018 Dec 24 doi: 10.1080/14740338.2019.1559294. PMID: 30582380
Treatment Patterns and Clinical Outcomes in Patients With Metastatic Gastroenteropancreatic Neuroendocrine Tumors Treated in the Community Practice Setting in the United States.
Jiao X, Pulgar S, Boyd M, Braiteh F, Mirakhur B, Pitman Lowenthal S, Fox P, Frytak J, Cox D, Paulson AS
Pancreas 2018 Feb;47(2):173-182. doi: 10.1097/MPA.0000000000000955. PMID: 29206668
Localization of Unknown Primary Site with (68)Ga-DOTATOC PET/CT in Patients with Metastatic Neuroendocrine Tumor.
Menda Y, O'Dorisio TM, Howe JR, Schultz M, Dillon JS, Dick D, Watkins GL, Ginader T, Bushnell DL, Sunderland JJ, Zamba GKD, Graham M, O'Dorisio MS
J Nucl Med 2017 Jul;58(7):1054-1057. Epub 2017 Feb 2 doi: 10.2967/jnumed.116.180984. PMID: 28153957Free PMC Article
Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables.
Sher LS, Levi DM, Wecsler JS, Lo M, Petrovic LM, Groshen S, Ji L, Uso TD, Tector AJ, Hamilton AS, Marsh JW, Schwartz ME
J Surg Oncol 2015 Aug;112(2):125-32. Epub 2015 Jul 14 doi: 10.1002/jso.23973. PMID: 26171686Free PMC Article

Recent systematic reviews

Systematic Review and Meta-Analysis on the Role of Chemotherapy in Advanced and Metastatic Neuroendocrine Tumor (NET).
Wong MH, Chan DL, Lee A, Li BT, Lumba S, Clarke SJ, Samra J, Pavlakis N
PLoS One 2016;11(6):e0158140. Epub 2016 Jun 30 doi: 10.1371/journal.pone.0158140. PMID: 27362760Free PMC Article

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