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Non-Neoplastic Cardiovascular Disorder

MedGen UID:
233232
Concept ID:
C1334999
Disease or Syndrome
Synonym: Non-Neoplastic Cardiovascular Disease

Definition

A non-neoplastic disorder that affects the heart and/or vessels. Representative examples include myocardial infarction, endocarditis, arteriosclerosis, thrombosis, and lymphedema. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Cardiovascular Disorder

Professional guidelines

PubMed

Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, Nuzzi V, Bessi R, Pagura L, Massa L, Sinagra G
Curr Cardiol Rep 2020 Oct 10;22(12):169. doi: 10.1007/s11886-020-01420-z. PMID: 33040219Free PMC Article
Maleszewski JJ, Anavekar NS, Moynihan TJ, Klarich KW
Nat Rev Cardiol 2017 Sep;14(9):536-549. Epub 2017 Apr 24 doi: 10.1038/nrcardio.2017.47. PMID: 28436488

Recent clinical studies

Etiology

Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Zafar A, Fiani B, Hadi H, Arshad M, Cathel A, Naeem M, Parsons MS, Farooqui M, Bucklin AA, Leone MJ, Baig A, Quadri SA
Neurol Sci 2020 Sep;41(9):2407-2421. Epub 2020 Apr 25 doi: 10.1007/s10072-020-04415-4. PMID: 32335778
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Bhatt S, Jafri SZ, Wasserman N, Dogra VS
Diagn Interv Radiol 2011 Mar;17(1):52-63. Epub 2010 Jun 30 doi: 10.4261/1305-3825.DIR.3116-09.0. PMID: 20677130

Diagnosis

Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Sangiorgio VFI, Arber DA
Semin Diagn Pathol 2021 Mar;38(2):154-158. Epub 2020 Jul 8 doi: 10.1053/j.semdp.2020.07.001. PMID: 32674844
Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, Nuzzi V, Bessi R, Pagura L, Massa L, Sinagra G
Curr Cardiol Rep 2020 Oct 10;22(12):169. doi: 10.1007/s11886-020-01420-z. PMID: 33040219Free PMC Article
Henriksen KJ, Chang A
Semin Nephrol 2020 Jan;40(1):69-75. doi: 10.1016/j.semnephrol.2019.12.008. PMID: 32130968
Patel N, Kolakalapudi P, Arora G
Echocardiography 2018 Mar;35(3):401-409. Epub 2018 Feb 23 doi: 10.1111/echo.13845. PMID: 29474744Free PMC Article

Therapy

Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4, Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration
EBioMedicine 2023 May;91:104510. Epub 2023 Apr 20 doi: 10.1016/j.ebiom.2023.104510. PMID: 37086649Free PMC Article
Sallman DA, Kerre T, Havelange V, Poiré X, Lewalle P, Wang ES, Brayer JB, Davila ML, Moors I, Machiels JP, Awada A, Alcantar-Orozco EM, Borissova R, Braun N, Dheur MS, Gilham DE, Lonez C, Lehmann FF, Flament A
Lancet Haematol 2023 Mar;10(3):e191-e202. Epub 2023 Feb 7 doi: 10.1016/S2352-3026(22)00378-7. PMID: 36764323
Kelly AG, Panigrahy D
Cold Spring Harb Perspect Med 2023 Mar 1;13(3) doi: 10.1101/cshperspect.a041172. PMID: 35817542Free PMC Article
Maleszewski JJ, Anavekar NS, Moynihan TJ, Klarich KW
Nat Rev Cardiol 2017 Sep;14(9):536-549. Epub 2017 Apr 24 doi: 10.1038/nrcardio.2017.47. PMID: 28436488
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article

Prognosis

Krywanczyk AR, Tan CD, Rodriguez ER
Curr Cardiol Rep 2021 Jul 16;23(9):119. doi: 10.1007/s11886-021-01548-6. PMID: 34269901
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Sangiorgio VFI, Arber DA
Semin Diagn Pathol 2021 Mar;38(2):154-158. Epub 2020 Jul 8 doi: 10.1053/j.semdp.2020.07.001. PMID: 32674844
Bussani R, Castrichini M, Restivo L, Fabris E, Porcari A, Ferro F, Pivetta A, Korcova R, Cappelletto C, Manca P, Nuzzi V, Bessi R, Pagura L, Massa L, Sinagra G
Curr Cardiol Rep 2020 Oct 10;22(12):169. doi: 10.1007/s11886-020-01420-z. PMID: 33040219Free PMC Article
Patel N, Kolakalapudi P, Arora G
Echocardiography 2018 Mar;35(3):401-409. Epub 2018 Feb 23 doi: 10.1111/echo.13845. PMID: 29474744Free PMC Article

Clinical prediction guides

Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Takeuchi S, Nagatani K, Otani N, Wada K, Mori K
J Clin Neurosci 2015 Dec;22(12):1959-62. Epub 2015 Sep 11 doi: 10.1016/j.jocn.2015.04.028. PMID: 26365482
Bonsib SM, Pei Y
Adv Anat Pathol 2010 Jul;17(4):235-50. doi: 10.1097/PAP.0b013e3181e3c02d. PMID: 20574169
Regauer S
Eur J Cell Biol 2005 Mar;84(2-3):273-7. doi: 10.1016/j.ejcb.2004.12.003. PMID: 15819407

Recent systematic reviews

Hellwig M, Diel P, Eisenbrand G, Grune T, Guth S, Henle T, Humpf HU, Joost HG, Marko D, Raupbach J, Roth A, Vieths S, Mally A
Crit Rev Toxicol 2024 Sep;54(8):485-617. Epub 2024 Aug 16 doi: 10.1080/10408444.2024.2362985. PMID: 39150724

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