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Laryngeal sarcoma

MedGen UID:
233610
•Concept ID:
C1334377
•
Neoplastic Process
Synonyms: Laryngeal Sarcoma; laryngeal sarcoma; Larynx Sarcoma; larynx sarcoma; Sarcoma of Larynx; sarcoma of larynx; Sarcoma of the Larynx; sarcoma of the larynx
 
Monarch Initiative: MONDO:0002448

Definition

A rare sarcoma that arises from soft tissue or hyaline cartilage of the larynx. [from NCI]

Professional guidelines

PubMed

Sarcoma of the larynx: treatment results and literature review.
Liu CY, Wang MC, Li WY, Chang SY, Chu PY
J Chin Med Assoc 2006 Mar;69(3):120-4. doi: 10.1016/S1726-4901(09)70189-3. PMID: 16599017

Recent clinical studies

Etiology

Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases.
Ramdulari AV, Izzuddeen Y, Benson R, Mallick S, Venkatesulu B, Giridhar P
Head Neck 2021 May;43(5):1421-1427. Epub 2021 Jan 14 doi: 10.1002/hed.26604. PMID: 33448036
Pediatric laryngeal sarcoma: Systematic review and pooled analysis.
Mur TA, Pellegrini WR, Jaleel Z, Edwards HA, Levi JR
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110471. Epub 2020 Oct 23 doi: 10.1016/j.ijporl.2020.110471. PMID: 33120103
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Sarcoma of the larynx: treatment results and literature review.
Liu CY, Wang MC, Li WY, Chang SY, Chu PY
J Chin Med Assoc 2006 Mar;69(3):120-4. doi: 10.1016/S1726-4901(09)70189-3. PMID: 16599017
Postirradiation laryngeal osteosarcoma: case report and literature review.
Sheen TS, Wu CT, Hsieh T, Hsu MM
Head Neck 1997 Jan;19(1):57-62. doi: 10.1002/(sici)1097-0347(199701)19:1<57::aid-hed11>3.0.co;2-o. PMID: 9030947

Diagnosis

Laryngeal Embryonal Rhabdomyosarcoma: A rare adult neoplasm.
Hafiz Yusuf F, Shaikh I, Hussain M, Arif A, Rahim D, Hafeez Siddiqui A, Farrukh S, Saleem Tebha S, Huma ZE
Ear Nose Throat J 2025 Jan;104(1):25-29. Epub 2022 Apr 1 doi: 10.1177/01455613221083795. PMID: 35363089
Laryngeal Synovial Sarcoma: A Systematic Review of the Last 40 Years of Reported Cases.
Shein G, Sandhu G, Potter A, Loo C, Jacobson I, Anazodo A
Ear Nose Throat J 2021 Feb;100(2):NP93-NP104. Epub 2019 Jul 16 doi: 10.1177/0145561319850697. PMID: 31309846
Pediatric laryngeal sarcoma: Systematic review and pooled analysis.
Mur TA, Pellegrini WR, Jaleel Z, Edwards HA, Levi JR
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110471. Epub 2020 Oct 23 doi: 10.1016/j.ijporl.2020.110471. PMID: 33120103
Laryngeal alveolar soft part sarcoma: A case report of a rare malignancy in an atypical location.
Tamaki A, Wasman J, Weidenbecher M
Am J Otolaryngol 2017 Mar-Apr;38(2):260-262. Epub 2017 Jan 18 doi: 10.1016/j.amjoto.2017.01.017. PMID: 28131550
Laryngeal malignancy following iodine-125 therapy for thyrotoxicosis.
McKillop JH, Doig JA, Kennedy JS, Thomson JA, Greig WR
Lancet 1978 Dec 2;2(8101):1177-9. doi: 10.1016/s0140-6736(78)92158-x. PMID: 82143

Therapy

Laryngeal Synovial Sarcoma: A Systematic Review of the Last 40 Years of Reported Cases.
Shein G, Sandhu G, Potter A, Loo C, Jacobson I, Anazodo A
Ear Nose Throat J 2021 Feb;100(2):NP93-NP104. Epub 2019 Jul 16 doi: 10.1177/0145561319850697. PMID: 31309846
Postirradiation laryngeal osteosarcoma: case report and literature review.
Sheen TS, Wu CT, Hsieh T, Hsu MM
Head Neck 1997 Jan;19(1):57-62. doi: 10.1002/(sici)1097-0347(199701)19:1<57::aid-hed11>3.0.co;2-o. PMID: 9030947
Laryngeal malignancy following iodine-125 therapy for thyrotoxicosis.
McKillop JH, Doig JA, Kennedy JS, Thomson JA, Greig WR
Lancet 1978 Dec 2;2(8101):1177-9. doi: 10.1016/s0140-6736(78)92158-x. PMID: 82143

Prognosis

Laryngeal rare benign non-epithelial tumors and sarcomas emphasizing on chondrosarcomas: A literature review and a case presentation.
Vageli DP, Doukas PG, Paraskeva AN, Zacharouli K, Judson BL, Ioannou M
Pathol Res Pract 2024 Sep;261:155512. Epub 2024 Jul 30 doi: 10.1016/j.prp.2024.155512. PMID: 39116572
Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases.
Ramdulari AV, Izzuddeen Y, Benson R, Mallick S, Venkatesulu B, Giridhar P
Head Neck 2021 May;43(5):1421-1427. Epub 2021 Jan 14 doi: 10.1002/hed.26604. PMID: 33448036
Differing characteristics of cartilaginous lesions of the larynx.
Ferlito A, Devaney KO, Mäkitie AA
Eur Arch Otorhinolaryngol 2019 Oct;276(10):2635-2647. Epub 2019 Jul 23 doi: 10.1007/s00405-019-05563-w. PMID: 31338576Free PMC Article
Sarcoma of the larynx: treatment results and literature review.
Liu CY, Wang MC, Li WY, Chang SY, Chu PY
J Chin Med Assoc 2006 Mar;69(3):120-4. doi: 10.1016/S1726-4901(09)70189-3. PMID: 16599017
Postirradiation laryngeal osteosarcoma: case report and literature review.
Sheen TS, Wu CT, Hsieh T, Hsu MM
Head Neck 1997 Jan;19(1):57-62. doi: 10.1002/(sici)1097-0347(199701)19:1<57::aid-hed11>3.0.co;2-o. PMID: 9030947

Recent systematic reviews

Laryngeal soft tissue sarcoma: Systematic review and individual patient data analysis of 300 cases.
Ramdulari AV, Izzuddeen Y, Benson R, Mallick S, Venkatesulu B, Giridhar P
Head Neck 2021 May;43(5):1421-1427. Epub 2021 Jan 14 doi: 10.1002/hed.26604. PMID: 33448036
Laryngeal Synovial Sarcoma: A Systematic Review of the Last 40 Years of Reported Cases.
Shein G, Sandhu G, Potter A, Loo C, Jacobson I, Anazodo A
Ear Nose Throat J 2021 Feb;100(2):NP93-NP104. Epub 2019 Jul 16 doi: 10.1177/0145561319850697. PMID: 31309846
Pediatric laryngeal sarcoma: Systematic review and pooled analysis.
Mur TA, Pellegrini WR, Jaleel Z, Edwards HA, Levi JR
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110471. Epub 2020 Oct 23 doi: 10.1016/j.ijporl.2020.110471. PMID: 33120103

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