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Localized Carcinoma

MedGen UID:
233616
•Concept ID:
C1334407
•
Neoplastic Process

Definition

A carcinoma that is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Radiotherapy Alone or With Chemotherapy in the Management of Carcinoma of the Supraglottic Larynx: A 25-Year Community Hospital Experience.
Rao AR, Jones DA, Mendenhall CM, Rizvi SN, Kirwan J, Morris CG, Johns A, McAfee WJ, Mendenhall WM
Am J Clin Oncol 2018 Sep;41(9):894-897. doi: 10.1097/COC.0000000000000398. PMID: 28654571
Carcinoma of the prostate: a model for management under impending health care system reform. 1994 RSNA annual oration in radiation oncology.
Perez CA
Radiology 1995 Aug;196(2):309-22. doi: 10.1148/radiology.196.2.7617839. PMID: 7617839
Transoral management of localized carcinoma of the oral cavity using the CO2 laser.
Strong MS, Vaughan CW, Healy GB, Shapshay SM, Jako GJ
Laryngoscope 1979 Jun;89(6 Pt 1):897-905. doi: 10.1288/00005537-197906000-00005. PMID: 449535

Recent clinical studies

Etiology

Dose fractionation and biological optimization in carcinoma of the prostate.
Perez CA
Rays 2004 Jul-Sep;29(3):237-52. PMID: 15603294
Age and racial distribution of prostatic intraepithelial neoplasia.
Sakr WA, Grignon DJ, Haas GP, Heilbrun LK, Pontes JE, Crissman JD
Eur Urol 1996;30(2):138-44. doi: 10.1159/000474163. PMID: 8875194
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus.
Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L, Emami B
N Engl J Med 1992 Jun 11;326(24):1593-8. doi: 10.1056/NEJM199206113262403. PMID: 1584260
Acute side effects and late complications after radiotherapy of localized carcinoma of the prostate.
Dewit L, Ang KK, Van der Schueren E
Cancer Treat Rev 1983 Jun;10(2):79-89. doi: 10.1016/0305-7372(83)90006-3. PMID: 6409407

Diagnosis

Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents.
Khamis ZI, Iczkowski KA, Sang QX
Med Res Rev 2012 Sep;32(5):1026-77. Epub 2011 Jan 16 doi: 10.1002/med.20232. PMID: 22886631
Radiosensitization of prostate cancer by priming the wild-type p53-dependent cellular senescence pathway.
Lehmann BD, McCubrey JA, Terrian DM
Cancer Biol Ther 2007 Aug;6(8):1165-70. Epub 2007 Aug 5 doi: 10.4161/cbt.6.8.4544. PMID: 18059157Free PMC Article
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002092. doi: 10.1002/14651858.CD002092.pub2. PMID: 16437440
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191
Localized carcinoma of the external ear is an unrecognized aggressive disease with a high propensity for local regional recurrence.
Yoon M, Chougule P, Dufresne R, Wanebo HJ
Am J Surg 1992 Dec;164(6):574-7. doi: 10.1016/s0002-9610(05)80709-3. PMID: 1463102

Therapy

Trimodality therapy without a platinum compound for localized carcinoma of the esophagus and gastroesophageal junction.
Ajani JA, Correa AM, Walsh GL, Komaki R, Lee JH, Vaporciyan AA, Rice DC, Yao JC, Maru DM, Hofstetter WL, Phan AT, Swisher SG
Cancer 2010 Apr 1;116(7):1656-63. doi: 10.1002/cncr.24935. PMID: 20143431
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191
Localized carcinoma of the prostate (stages T1B, T1C, T2, and T3). Review of management with external beam radiation therapy.
Perez CA, Hanks GE, Leibel SA, Zietman AL, Fuks Z, Lee WR
Cancer 1993 Dec 1;72(11):3156-73. doi: 10.1002/1097-0142(19931201)72:11<3156::aid-cncr2820721106>3.0.co;2-g. PMID: 7694785
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus.
Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L, Emami B
N Engl J Med 1992 Jun 11;326(24):1593-8. doi: 10.1056/NEJM199206113262403. PMID: 1584260
Acute side effects and late complications after radiotherapy of localized carcinoma of the prostate.
Dewit L, Ang KK, Van der Schueren E
Cancer Treat Rev 1983 Jun;10(2):79-89. doi: 10.1016/0305-7372(83)90006-3. PMID: 6409407

Prognosis

Neoadjuvant androgen ablation in localized carcinoma of the prostate.
Kish JA
Cancer Control 2001 Mar-Apr;8(2):155-62. doi: 10.1177/107327480100800206. PMID: 11326170
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191
Localized carcinoma of the prostate (stages T1B, T1C, T2, and T3). Review of management with external beam radiation therapy.
Perez CA, Hanks GE, Leibel SA, Zietman AL, Fuks Z, Lee WR
Cancer 1993 Dec 1;72(11):3156-73. doi: 10.1002/1097-0142(19931201)72:11<3156::aid-cncr2820721106>3.0.co;2-g. PMID: 7694785
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus.
Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L, Emami B
N Engl J Med 1992 Jun 11;326(24):1593-8. doi: 10.1056/NEJM199206113262403. PMID: 1584260
Localized carcinoma of the external ear is an unrecognized aggressive disease with a high propensity for local regional recurrence.
Yoon M, Chougule P, Dufresne R, Wanebo HJ
Am J Surg 1992 Dec;164(6):574-7. doi: 10.1016/s0002-9610(05)80709-3. PMID: 1463102

Clinical prediction guides

Trimodality therapy without a platinum compound for localized carcinoma of the esophagus and gastroesophageal junction.
Ajani JA, Correa AM, Walsh GL, Komaki R, Lee JH, Vaporciyan AA, Rice DC, Yao JC, Maru DM, Hofstetter WL, Phan AT, Swisher SG
Cancer 2010 Apr 1;116(7):1656-63. doi: 10.1002/cncr.24935. PMID: 20143431
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2001;(2):CD002092. doi: 10.1002/14651858.CD002092. PMID: 11406033
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191
Localized carcinoma of the prostate (stages T1B, T1C, T2, and T3). Review of management with external beam radiation therapy.
Perez CA, Hanks GE, Leibel SA, Zietman AL, Fuks Z, Lee WR
Cancer 1993 Dec 1;72(11):3156-73. doi: 10.1002/1097-0142(19931201)72:11<3156::aid-cncr2820721106>3.0.co;2-g. PMID: 7694785

Recent systematic reviews

WITHDRAWN. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong RK, Malthaner R
Cochrane Database Syst Rev 2010 Jan 20;2010(1):CD002092. doi: 10.1002/14651858.CD002092.pub3. PMID: 20091530Free PMC Article
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002092. doi: 10.1002/14651858.CD002092.pub2. PMID: 16437440
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2001;(2):CD002092. doi: 10.1002/14651858.CD002092. PMID: 11406033

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