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Lung Carcinoma Metastatic in the Bone

MedGen UID:
233627
•Concept ID:
C1334440
•
Neoplastic Process
Synonym: Lung Carcinoma Metastatic to the Bone

Definition

A carcinoma that arises from the lung and has metastasized to the bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Carcinoma Metastatic in the Bone

Professional guidelines

PubMed

Outcome of First-Line Treatment With Pembrolizumab According to KRAS/TP53 Mutational Status for Nonsquamous Programmed Death-Ligand 1-High (≥50%) NSCLC in the German National Network Genomic Medicine Lung Cancer.
Bischoff P, Reck M, Overbeck T, Christopoulos P, Rittmeyer A, Lüders H, Kollmeier J, Kulhavy J, Kemper M, Reinmuth N, Röper J, Janning M, Sommer L, Aguinarte L, Koch M, Wiesweg M, Wesseler C, Waller CF, Kauffmann-Guerrero D, Stenzinger A, Stephan-Falkenau S, Trautmann M, Lassmann S, Tiemann M, Klauschen F, Sebastian M, Griesinger F, Wolf J, Loges S, Frost N; National Network Genomic Medicine Lung Cancer (nNGM) Collaborator Group
J Thorac Oncol 2024 May;19(5):803-817. Epub 2023 Dec 13 doi: 10.1016/j.jtho.2023.12.015. PMID: 38096950
Management of Lung Cancer Presenting with Solitary Bone Metastasis.
Nistor CE, Ciuche A, Cucu AP, Nitipir C, Slavu C, Serban B, Cursaru A, Cretu B, Cirstoiu C
Medicina (Kaunas) 2022 Oct 16;58(10) doi: 10.3390/medicina58101463. PMID: 36295624Free PMC Article
Barriers to nausea management, end of life conversations, early palliative care interventions, and patient education.
Simone CB 2nd
Ann Palliat Med 2017 Jan;6(1):E1-E4. doi: 10.21037/apm.2017.02.01. PMID: 28209067

Recent clinical studies

Etiology

Bone metastasis in esophageal adenocarcinoma and squamous cell carcinoma: a SEER-based study.
Qin Y, Mao J, Liang X, Wang N, Yuan M, Zhu J, Wu D, Wang Q
Gen Thorac Cardiovasc Surg 2022 May;70(5):479-490. Epub 2022 Jan 19 doi: 10.1007/s11748-021-01765-4. PMID: 35044634
Clinical features and outcomes of metastatic bone tumors of the pelvis.
Yang Q, Chen N, Fu W
J Int Med Res 2021 Jun;49(6):3000605211013152. doi: 10.1177/03000605211013152. PMID: 34154434Free PMC Article
The value of biomarkers in bone metastasis.
D'Oronzo S, Brown J, Coleman R
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Jun 27 doi: 10.1111/ecc.12725. PMID: 28653449
Metastatic carcinoma to the acromion in a patient after total shoulder arthroplasty: a case report and review of the literature.
Woodhouse ES, Fehringer EV, Benda PM, Matsen FA 3rd
J Shoulder Elbow Surg 2002 Nov-Dec;11(6):645-7. doi: 10.1067/mse.2002.126762. PMID: 12469096
Pulmonary hamartomas.
Gjevre JA, Myers JL, Prakash UB
Mayo Clin Proc 1996 Jan;71(1):14-20. doi: 10.4065/71.1.14. PMID: 8538225

Diagnosis

Metastatic Hurthle cell cancer.
de Melo ASA, de Oliveira Rodrigues MF, Marchiori E
QJM 2019 Jun 1;112(6):453-454. doi: 10.1093/qjmed/hcy297. PMID: 30576521
Miliary Nodules: Not Always Tuberculosis.
Kimmig L, Bueno J
Ann Am Thorac Soc 2017 Dec;14(12):1858-1860. doi: 10.1513/AnnalsATS.201706-436CC. PMID: 29192819
Acrometastasis as the initial presentation of lung adenocarcinoma in a young woman.
Gorospe Sarasúa L, Mezquita Pérez L, Pacios Blanco RE
Arch Bronconeumol 2016 Sep;52(9):482-3. Epub 2015 Dec 2 doi: 10.1016/j.arbres.2015.10.007. PMID: 26654634
Acrometastases.
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Metastatic carcinoma to the acromion in a patient after total shoulder arthroplasty: a case report and review of the literature.
Woodhouse ES, Fehringer EV, Benda PM, Matsen FA 3rd
J Shoulder Elbow Surg 2002 Nov-Dec;11(6):645-7. doi: 10.1067/mse.2002.126762. PMID: 12469096

Therapy

Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.
Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520
Metastatic Hepatocellular Carcinoma Treated With Zoledronic Acid.
Nguyen AL, Cao H, Thinn MM
J Oncol Pract 2018 Jan;14(1):52-54. Epub 2017 Sep 25 doi: 10.1200/JOP.2017.023770. PMID: 28945506
EGFR mutations in squamous cell lung cancer in never-smokers.
Baik CS, Pritchard CC, Eaton KD, Chow LQ
J Thorac Oncol 2013 Jan;8(1):e6-7. doi: 10.1097/JTO.0b013e3182762d49. PMID: 23242446
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial.
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, Zarbá JJ, Chen M, McCann L, Pandite L, Roychowdhury DF, Hawkins RE
J Clin Oncol 2010 Feb 20;28(6):1061-8. Epub 2010 Jan 25 doi: 10.1200/JCO.2009.23.9764. PMID: 20100962
Embolization and subsequent nephrectomy in metastatic renal cell carcinoma.
Kurth KH, Cinqualbre J, Oliver RT, Schulman CC
Prog Clin Biol Res 1984;153:423-36. PMID: 6206510

Prognosis

Metastatic Hurthle cell cancer.
de Melo ASA, de Oliveira Rodrigues MF, Marchiori E
QJM 2019 Jun 1;112(6):453-454. doi: 10.1093/qjmed/hcy297. PMID: 30576521
AFP-producing lung squamous carcinoma.
Liu M, Liu B, Zhou Y, Quan X, Liu B, Dong L
QJM 2016 Dec;109(12):813-814. Epub 2016 Nov 8 doi: 10.1093/qjmed/hcw179. PMID: 28034920
Pulmonary lymphangitic carcinomatosis.
Lin WR, Lai RS
QJM 2014 Nov;107(11):935-6. Epub 2014 Apr 8 doi: 10.1093/qjmed/hcu076. PMID: 24713225
Acrometastases.
Mavrogenis AF, Mimidis G, Kokkalis ZT, Karampi ES, Karampela I, Papagelopoulos PJ, Armaganidis A
Eur J Orthop Surg Traumatol 2014 Apr;24(3):279-83. Epub 2013 Sep 8 doi: 10.1007/s00590-013-1311-1. PMID: 24013815
Metastatic carcinoma to the acromion in a patient after total shoulder arthroplasty: a case report and review of the literature.
Woodhouse ES, Fehringer EV, Benda PM, Matsen FA 3rd
J Shoulder Elbow Surg 2002 Nov-Dec;11(6):645-7. doi: 10.1067/mse.2002.126762. PMID: 12469096

Clinical prediction guides

Metastasis and recurrence patterns in the molecular subtypes of urothelial bladder cancer.
Sjödahl G, Eriksson P, Holmsten K, Abrahamsson J, Höglund M, Bernardo C, Ullén A, Liedberg F
Int J Cancer 2024 Jan 1;154(1):180-190. Epub 2023 Sep 6 doi: 10.1002/ijc.34715. PMID: 37671617
Specific organ metastases and prognosis in lung adenocarcinoma.
Zhao Z, Gao Y, Tan F, Xue Q, Gao S, He J
Thorac Cancer 2023 Mar;14(8):736-745. Epub 2023 Jan 24 doi: 10.1111/1759-7714.14801. PMID: 36694094Free PMC Article
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF
Cancer Lett 2021 Nov 1;520:80-90. Epub 2021 Jul 4 doi: 10.1016/j.canlet.2021.06.030. PMID: 34233150Free PMC Article
The value of biomarkers in bone metastasis.
D'Oronzo S, Brown J, Coleman R
Eur J Cancer Care (Engl) 2017 Nov;26(6) Epub 2017 Jun 27 doi: 10.1111/ecc.12725. PMID: 28653449
A pilot evaluation of micrometastases for the prediction of outcome in lung cancer.
Thompson AB, Kessinger A, Sharp JG
Chest 2004 May;125(5 Suppl):156S-7S. doi: 10.1378/chest.125.5_suppl.156s-a. PMID: 15136484

Recent systematic reviews

Sensitivities evaluation of five radiopharmaceuticals in four common medullary thyroid carcinoma metastatic sites on PET/CT: a network meta-analysis and systematic review.
Li P, Zhang Y, Xu T, Zhu J, Wei T, Zhao W
Nucl Med Commun 2023 Dec 1;44(12):1114-1125. Epub 2023 Sep 29 doi: 10.1097/MNM.0000000000001773. PMID: 37769014Free PMC Article
Metastatic pituitary tumors: an institutional case series.
Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025
Acrometastases to the Hand: A Systematic Review.
Umana GE, Scalia G, Palmisciano P, Passanisi M, Da Ros V, Pompili G, Barone F, Amico P, Tomasi SO, Graziano F, Patti IV, Mele S, Maugeri R, Raffa G, Giammalva GR, Iacopino GD, Germanò A, Nicoletti GF, Ippolito M, Sabini MG, Cicero S, Strigari L, Cuttone G
Medicina (Kaunas) 2021 Sep 9;57(9) doi: 10.3390/medicina57090950. PMID: 34577873Free PMC Article
Metastatic sites as predictors in advanced NSCLC treated with PD-1 inhibitors: a systematic review and meta-analysis.
Huang Y, Zhu L, Guo T, Chen W, Zhang Z, Li W, Pan X
Hum Vaccin Immunother 2021 May 4;17(5):1278-1287. Epub 2020 Oct 20 doi: 10.1080/21645515.2020.1823779. PMID: 33079622Free PMC Article
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

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