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Malignant gastric germ cell tumor

MedGen UID:
233663
•Concept ID:
C1334584
•
Neoplastic Process
Synonyms: germ cell tumor of the stomach; germ cell tumour of the stomach; Malignant Gastric Germ Cell Neoplasm; malignant gastric germ cell neoplasm; Malignant Gastric Germ Cell Tumor; malignant gastric germ cell tumor; Malignant Germ Cell Neoplasm of Stomach; malignant germ cell neoplasm of stomach; Malignant Germ Cell Neoplasm of the Stomach; malignant germ cell neoplasm of the stomach; Malignant Germ Cell Tumor of Stomach; malignant germ cell tumor of stomach; Malignant Germ Cell Tumor of the Stomach; malignant germ cell tumor of the stomach; malignant germ cell tumour of stomach; malignant germ cell tumour of the stomach
 
Monarch Initiative: MONDO:0003112

Definition

A malignant germ cell tumor that arises from the stomach. It includes choriocarcinoma and immature teratoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant gastric germ cell tumor

Professional guidelines

PubMed

Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Pavel M, Öberg K, Falconi M, Krenning EP, Sundin A, Perren A, Berruti A; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2020 Jul;31(7):844-860. Epub 2020 Apr 6 doi: 10.1016/j.annonc.2020.03.304. PMID: 32272208
Management of gastric and duodenal neuroendocrine tumors.
Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S
World J Gastroenterol 2016 Aug 14;22(30):6817-28. doi: 10.3748/wjg.v22.i30.6817. PMID: 27570419Free PMC Article

Recent clinical studies

Etiology

Management of Gastric Neuroendocrine Tumors: A Review.
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Current understanding of pathogenetic mechanisms in neuroendocrine neoplasms.
Modica R, Liccardi A, Minotta R, Cannavale G, Benevento E, Colao A
Expert Rev Endocrinol Metab 2024 Jan-May;19(1):49-61. Epub 2024 Jan 1 doi: 10.1080/17446651.2023.2279540. PMID: 37936421
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Pavel M, Öberg K, Falconi M, Krenning EP, Sundin A, Perren A, Berruti A; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2020 Jul;31(7):844-860. Epub 2020 Apr 6 doi: 10.1016/j.annonc.2020.03.304. PMID: 32272208
Gastric neuroendocrine tumours.
Crosby DA, Donohoe CL, Fitzgerald L, Muldoon C, Hayes B, O'Toole D, Reynolds JV
Dig Surg 2012;29(4):331-48. Epub 2012 Oct 17 doi: 10.1159/000342988. PMID: 23075625

Diagnosis

European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3.
Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Microbiome and Gastric Cancer.
Engstrand L, Graham DY
Dig Dis Sci 2020 Mar;65(3):865-873. doi: 10.1007/s10620-020-06101-z. PMID: 32040665Free PMC Article
GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE.
Dias AR, Azevedo BC, Alban LBV, Yagi OK, Ramos MFKP, Jacob CE, Barchi LC, Cecconello I, Ribeiro U Jr, Zilberstein B
Arq Bras Cir Dig 2017 Apr-Jun;30(2):150-154. doi: 10.1590/0102-6720201700020016. PMID: 29257854Free PMC Article
Management of gastric and duodenal neuroendocrine tumors.
Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S
World J Gastroenterol 2016 Aug 14;22(30):6817-28. doi: 10.3748/wjg.v22.i30.6817. PMID: 27570419Free PMC Article

Therapy

[(177)Lu]Lu-DOTA-TATE plus long-acting octreotide versus high‑dose long-acting octreotide for the treatment of newly diagnosed, advanced grade 2-3, well-differentiated, gastroenteropancreatic neuroendocrine tumours (NETTER-2): an open-label, randomised, phase 3 study.
Singh S, Halperin D, Myrehaug S, Herrmann K, Pavel M, Kunz PL, Chasen B, Tafuto S, Lastoria S, Capdevila J, García-Burillo A, Oh DY, Yoo C, Halfdanarson TR, Falk S, Folitar I, Zhang Y, Aimone P, de Herder WW, Ferone D; all the NETTER-2 Trial Investigators
Lancet 2024 Jun 29;403(10446):2807-2817. Epub 2024 Jun 5 doi: 10.1016/S0140-6736(24)00701-3. PMID: 38851203
Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
Avelumab in gastric cancer.
Roviello G, D'Angelo A, Generali D, Pittacolo M, Ganzinelli M, Iezzi G, Manzini N, Sobhani N
Immunotherapy 2019 Jun;11(9):759-768. Epub 2019 May 6 doi: 10.2217/imt-2019-0011. PMID: 31060469
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Gastric carcinoid.
Mulkeen A, Cha C
Curr Opin Oncol 2005 Jan;17(1):1-6. doi: 10.1097/01.cco.0000147899.04701.c6. PMID: 15608504

Prognosis

Cancer statistics, 2024.
Siegel RL, Giaquinto AN, Jemal A
CA Cancer J Clin 2024 Jan-Feb;74(1):12-49. Epub 2024 Jan 17 doi: 10.3322/caac.21820. PMID: 38230766
European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1-G3.
Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
GASTRIC NEUROENDOCRINE TUMOR: REVIEW AND UPDATE.
Dias AR, Azevedo BC, Alban LBV, Yagi OK, Ramos MFKP, Jacob CE, Barchi LC, Cecconello I, Ribeiro U Jr, Zilberstein B
Arq Bras Cir Dig 2017 Apr-Jun;30(2):150-154. doi: 10.1590/0102-6720201700020016. PMID: 29257854Free PMC Article

Clinical prediction guides

Immunotherapy for non-small cell lung cancer.
Kagamu H
Respir Investig 2024 Mar;62(2):307-312. Epub 2024 Feb 3 doi: 10.1016/j.resinv.2024.01.011. PMID: 38310751
First-Line Genomic Profiling in Previously Untreated Advanced Solid Tumors for Identification of Targeted Therapy Opportunities.
Matsubara J, Mukai K, Kondo T, Yoshioka M, Kage H, Oda K, Kudo R, Ikeda S, Ebi H, Muro K, Hayashi R, Tokudome N, Yamamoto N, Muto M
JAMA Netw Open 2023 Jul 3;6(7):e2323336. doi: 10.1001/jamanetworkopen.2023.23336. PMID: 37459099Free PMC Article
Epidemiologic Trends of and Factors Associated With Overall Survival for Patients With Gastroenteropancreatic Neuroendocrine Tumors in the United States.
Xu Z, Wang L, Dai S, Chen M, Li F, Sun J, Luo F
JAMA Netw Open 2021 Sep 1;4(9):e2124750. doi: 10.1001/jamanetworkopen.2021.24750. PMID: 34554237Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Recent systematic reviews

Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Primary gastric melanoma in adult population: a systematic review of the literature.
Schizas D, Tomara N, Katsaros I, Sakellariou S, Machairas N, Paspala A, Tsilimigras DI, Papanikolaou IS, Mantas D
ANZ J Surg 2021 Mar;91(3):269-275. Epub 2020 Jul 20 doi: 10.1111/ans.16160. PMID: 32687691
Imaging pediatric gastrointestinal stromal tumor (GIST).
Herzberg M, Beer M, Anupindi S, Vollert K, Kröncke T
J Pediatr Surg 2018 Sep;53(9):1862-1870. Epub 2018 Mar 29 doi: 10.1016/j.jpedsurg.2018.03.022. PMID: 29685489
Optimizing Somatostatin Analog Use in Well or Moderately Differentiated Gastroenteropancreatic Neuroendocrine Tumors.
Carmona-Bayonas A, Jiménez-Fonseca P, Custodio A, Grande E, Capdevila J, López C, Teule A, Garcia-Carbonero R; Spanish Neuroendocrine Tumor Group (GETNE)
Curr Oncol Rep 2017 Sep 18;19(11):72. doi: 10.1007/s11912-017-0633-2. PMID: 28920153
Risk factors for neuroendocrine neoplasms: a systematic review and meta-analysis.
Leoncini E, Carioli G, La Vecchia C, Boccia S, Rindi G
Ann Oncol 2016 Jan;27(1):68-81. Epub 2015 Oct 20 doi: 10.1093/annonc/mdv505. PMID: 26487581

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