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Mature ovarian teratoma

MedGen UID:
233672
•Concept ID:
C1334637
•
Neoplastic Process
Synonyms: Mature Ovarian Teratoma; mature ovarian teratoma; mature teratoma; Mature Teratoma of Ovary; mature teratoma of ovary; Mature Teratoma of the Ovary; mature teratoma of the ovary; ovary mature teratoma
 
Monarch Initiative: MONDO:0003820

Definition

An ovarian teratoma which may be cystic, composed entirely of well differentiated, adult-type tissues, without evidence of fetal-type tissues. [from NCI]

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Ovarian teratomas: clinical features, imaging findings and management.
Saleh M, Bhosale P, Menias CO, Ramalingam P, Jensen C, Iyer R, Ganeshan D
Abdom Radiol (NY) 2021 Jun;46(6):2293-2307. Epub 2021 Jan 4 doi: 10.1007/s00261-020-02873-0. PMID: 33394097
Differential diagnosis of gynaecological "stained glass" tumours on MRI.
Tanaka YO, Nishida M, Kurosaki Y, Itai Y, Tsunoda H, Kubo T
Br J Radiol 1999 Apr;72(856):414-20. doi: 10.1259/bjr.72.856.10474509. PMID: 10474509

Recent clinical studies

Etiology

Bilateral Mature Ovarian Teratoma with Torsion in a Premenarchal Girl.
Lešková J, Kříž JT, Štichhauer R
Acta Medica (Hradec Kralove) 2022;65(1):33-36. doi: 10.14712/18059694.2022.14. PMID: 35793507
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Ovarian Sparing Surgery in Mature Ovarian Teratomas in Children: A 20-Year Single-Center Experience.
Szymon O, Bogusz B, Taczanowska-Niemczuk A, Maślanka M, Górecki W
Eur J Pediatr Surg 2021 Feb;31(1):2-7. Epub 2020 Sep 19 doi: 10.1055/s-0040-1716877. PMID: 32950035
Benign enhancing components of mature ovarian teratoma: magnetic resonance imaging features and pathologic correlation.
Shin HJ, Kim KA, Kim BH, Lee JK, Park YS, Lee J, Choi JW, Lee CH, Park CM
Clin Imaging 2016 Nov-Dec;40(6):1156-1161. Epub 2016 Aug 5 doi: 10.1016/j.clinimag.2016.08.005. PMID: 27568071
Ovarian mature teratoma: a ten year experience in our institution.
Jalencas G, González Bosquet E, Guirado L, Fernandez Arias M, Ruiz de Gauna B, Fiores L, Gómez Roig MD, Callejo J
Clin Exp Obstet Gynecol 2015;42(4):518-22. PMID: 26411224

Diagnosis

Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma.
Chao A, Lai CH, Chao AS, Lin CY, Wang YC, Huang HJ, Wu RC
J Mol Med (Berl) 2025 Jan;103(1):101-111. Epub 2024 Dec 4 doi: 10.1007/s00109-024-02505-w. PMID: 39630279
A Subserosal Uterine Lipoleiomyoma Mimicking a Mature Ovarian Teratoma.
Chen G, Chen H, Sun W, Chen H, Fei X
J Minim Invasive Gynecol 2023 Sep;30(9):689-690. Epub 2023 Jun 3 doi: 10.1016/j.jmig.2023.05.017. PMID: 37276933
Mullerian Tissue (Endomyometriosis) and Intratumoral Bone Marrow Emboli From Long Bone in a Mature Ovarian Teratoma-A Keatsian Reminiscence.
Pai SA, Shenoy JV, Shafalika SB
Int J Surg Pathol 2023 Oct;31(7):1319-1322. Epub 2022 Dec 5 doi: 10.1177/10668969221137520. PMID: 36471510
Uterine leiomyoma causing menometrorrhagia with a concomitant mature teratoma in a 15-year-old child: a case report and review of the literature.
Naiditch JA, Milad MP, Rowell EE
J Pediatr Surg 2011 Oct;46(10):E33-6. doi: 10.1016/j.jpedsurg.2011.06.031. PMID: 22008360
Microdissection-based analysis of mature ovarian teratoma.
Vortmeyer AO, Devouassoux-Shisheboran M, Li G, Mohr V, Tavassoli F, Zhuang Z
Am J Pathol 1999 Apr;154(4):987-91. doi: 10.1016/S0002-9440(10)65350-3. PMID: 10233836Free PMC Article

Therapy

Ovarian Sparing Surgery in Mature Ovarian Teratomas in Children: A 20-Year Single-Center Experience.
Szymon O, Bogusz B, Taczanowska-Niemczuk A, Maślanka M, Górecki W
Eur J Pediatr Surg 2021 Feb;31(1):2-7. Epub 2020 Sep 19 doi: 10.1055/s-0040-1716877. PMID: 32950035
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1.
Collins B, Corey SJ
J Pediatr Hematol Oncol 2017 Aug;39(6):485-486. doi: 10.1097/MPH.0000000000000918. PMID: 28719514
Uterine leiomyoma causing menometrorrhagia with a concomitant mature teratoma in a 15-year-old child: a case report and review of the literature.
Naiditch JA, Milad MP, Rowell EE
J Pediatr Surg 2011 Oct;46(10):E33-6. doi: 10.1016/j.jpedsurg.2011.06.031. PMID: 22008360
Microdissection-based analysis of mature ovarian teratoma.
Vortmeyer AO, Devouassoux-Shisheboran M, Li G, Mohr V, Tavassoli F, Zhuang Z
Am J Pathol 1999 Apr;154(4):987-91. doi: 10.1016/S0002-9440(10)65350-3. PMID: 10233836Free PMC Article
Transformation of residual mature ovarian teratoma to adenocarcinoma 10 years after initial treatment.
Ahmed FY, Gore ME, Shepherd J, Fisher C
Clin Oncol (R Coll Radiol) 1996;8(2):125-6. doi: 10.1016/s0936-6555(96)80122-1. PMID: 8859614

Prognosis

Ovarian Sparing Surgery in Mature Ovarian Teratomas in Children: A 20-Year Single-Center Experience.
Szymon O, Bogusz B, Taczanowska-Niemczuk A, Maślanka M, Górecki W
Eur J Pediatr Surg 2021 Feb;31(1):2-7. Epub 2020 Sep 19 doi: 10.1055/s-0040-1716877. PMID: 32950035
Mature Ovarian Teratoma After Treatment for Unilateral Retinoblastoma With Nonmutated RB1.
Collins B, Corey SJ
J Pediatr Hematol Oncol 2017 Aug;39(6):485-486. doi: 10.1097/MPH.0000000000000918. PMID: 28719514
Uterine leiomyoma causing menometrorrhagia with a concomitant mature teratoma in a 15-year-old child: a case report and review of the literature.
Naiditch JA, Milad MP, Rowell EE
J Pediatr Surg 2011 Oct;46(10):E33-6. doi: 10.1016/j.jpedsurg.2011.06.031. PMID: 22008360
Rare growth of a psammomatous meningioma in a mature ovarian teratoma: a case report.
Mandal S, Dhingra K, Gupta P, Khurana N
Pathol Res Pract 2010 May 15;206(5):322-4. Epub 2009 Jul 18 doi: 10.1016/j.prp.2009.05.011. PMID: 19616897
Mature ovarian teratoma with gliomatosis peritonei--a case report.
Das CJ, Sharma R, Thulkar S, Mukhopadhyay S, Deka D, Mannan R
Indian J Cancer 2005 Jul-Sep;42(3):165-7. doi: 10.4103/0019-509x.17064. PMID: 16276020

Clinical prediction guides

Molecular characterization of ovarian squamous cell carcinoma originating from mature teratoma.
Chao A, Lai CH, Chao AS, Lin CY, Wang YC, Huang HJ, Wu RC
J Mol Med (Berl) 2025 Jan;103(1):101-111. Epub 2024 Dec 4 doi: 10.1007/s00109-024-02505-w. PMID: 39630279
Ovarian Sparing Surgery in Mature Ovarian Teratomas in Children: A 20-Year Single-Center Experience.
Szymon O, Bogusz B, Taczanowska-Niemczuk A, Maślanka M, Górecki W
Eur J Pediatr Surg 2021 Feb;31(1):2-7. Epub 2020 Sep 19 doi: 10.1055/s-0040-1716877. PMID: 32950035
Well-formed cerebellum and brainstem-like structures in a mature ovarian teratoma: Neuropathological observations.
Shintaku M, Sakuma T, Ohbayashi C, Maruo M
Neuropathology 2017 Apr;37(2):122-128. Epub 2017 Jan 2 doi: 10.1111/neup.12360. PMID: 28042664
Benign enhancing components of mature ovarian teratoma: magnetic resonance imaging features and pathologic correlation.
Shin HJ, Kim KA, Kim BH, Lee JK, Park YS, Lee J, Choi JW, Lee CH, Park CM
Clin Imaging 2016 Nov-Dec;40(6):1156-1161. Epub 2016 Aug 5 doi: 10.1016/j.clinimag.2016.08.005. PMID: 27568071
Metachronous benign ovarian tumors are not uncommon in children.
Taskinen S, Urtane A, Fagerholm R, Lohi J, Taskinen M
J Pediatr Surg 2014 Apr;49(4):543-5. Epub 2013 Oct 3 doi: 10.1016/j.jpedsurg.2013.09.019. PMID: 24726109

Recent systematic reviews

Prostatic tissue: an unexpected finding in a mature ovarian teratoma : Case report and systematic literature review.
Pecorella I, Framarino Dei Malatesta ML, Riganelli L, Ciardi G, Porpora MG
Arch Gynecol Obstet 2022 Apr;305(4):969-976. Epub 2021 Oct 7 doi: 10.1007/s00404-021-06245-x. PMID: 34618214Free PMC Article
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Laparoscopic approach to an incidentally found pelvic retroperitoneal liposarcoma: Case report and review.
Mandato VD, Mastrofilippo V, De Marco L, Aguzzoli L
Medicine (Baltimore) 2019 Apr;98(15):e15184. doi: 10.1097/MD.0000000000015184. PMID: 30985710Free PMC Article

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