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Non-seminomatous lesion

MedGen UID:
233785
•Concept ID:
C1335059
•
Neoplastic Process
Synonyms: Non-Seminomatous Lesion; non-seminomatous lesion; Nonseminoma; Nonseminomatous Lesion
 
Monarch Initiative: MONDO:0006323

Definition

A group of testicular cancers that begin in the germ cells (cells that give rise to sperm). Nonseminomas are identified by the type of cell in which they begin and include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac carcinoma. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-seminomatous lesion

Professional guidelines

PubMed

Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Diagnosing testicular lumps in primary care.
Stonier T, Simson N, Challacombe B
Practitioner 2017 Apr;261(1803):13-7. PMID: 29020728
Diagnostic value of 18F-FDG positron emission tomography for detection and treatment control of malignant germ cell tumors.
Tsatalpas P, Beuthien-Baumann B, Kropp J, Manseck A, Tiepolt C, Hakenberg OW, Burchert W, Franke WG, Wirth MP
Urol Int 2002;68(3):157-63. doi: 10.1159/000048442. PMID: 11919460

Recent clinical studies

Etiology

When to ask for an MRI of the scrotum.
Tsili AC, Argyropoulou MI, Dolciami M, Ercolani G, Catalano C, Manganaro L
Andrology 2021 Sep;9(5):1395-1409. Epub 2021 Jun 11 doi: 10.1111/andr.13032. PMID: 33964115Free PMC Article
Spontaneous gas in a retroperitoneal mass: check the testis!
Dana J, Maxwell F, Eiss D, Rocher L
Int Braz J Urol 2019 Jul-Aug;45(4):847-850. doi: 10.1590/S1677-5538.IBJU.2018.0606. PMID: 31038859Free PMC Article
Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
The growing teratoma syndrome.
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236
Non-seminomatous testicular tumors: effect of lesion side on CT detection of lymph node metastasis.
Munechika H, Cohan RH, Dunnick NR
Comput Med Imaging Graph 1988 Nov-Dec;12(6):343-8. doi: 10.1016/0895-6111(88)90074-2. PMID: 3208237

Diagnosis

Imaging Techniques to Differentiate Benign Testicular Masses from Germ Cell Tumors.
Saidian A, Bagrodia A
Curr Urol Rep 2023 Sep;24(9):451-454. Epub 2023 Jun 27 doi: 10.1007/s11934-023-01172-7. PMID: 37368095Free PMC Article
Choriocarcinoma syndrome: A rare presentation of testicular germ cell tumour.
Sindhu II, Noor N, Mansoor R
J Pak Med Assoc 2021 Aug;71(8):2090-2092. doi: 10.47391/JPMA.234. PMID: 34418038
When to ask for an MRI of the scrotum.
Tsili AC, Argyropoulou MI, Dolciami M, Ercolani G, Catalano C, Manganaro L
Andrology 2021 Sep;9(5):1395-1409. Epub 2021 Jun 11 doi: 10.1111/andr.13032. PMID: 33964115Free PMC Article
Skin metastasis: a rare presentation in testicular germ cell tumour.
Vanidassane I, Mittal A, Kumar C, Tanwar P, Sahoo RK, Batra A
BMJ Case Rep 2018 Sep 23;2018 doi: 10.1136/bcr-2018-226385. PMID: 30249738Free PMC Article
MRI for evaluation of scrotal pathology.
Schultz-Lampel D, Bogaert G, Thüroff JW, Schlegel E, Cramer B
Urol Res 1991;19(5):289-92. doi: 10.1007/BF00299060. PMID: 1659016

Therapy

Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Histopathological assessment of residual retroperitoneal mass removed in patients after chemotherapy for non-seminomatous germ cell tumours of the testis.
Jaszczyński J, Wilk W, Kruczak A, Wohadlo Ł, Faron P, Łuczyńska E, Chłosta P, Stelmach A, Jakubowicz J
Pol J Pathol 2015 Dec;66(4):420-5. doi: 10.5114/pjp.2015.57257. PMID: 27003776
Recurrence of a non-seminomatous germ cell tumor in the seminal vesicle 20 years after initial diagnosis and treatment.
Lattouf JB, Mc Cormack M, Yelle L, Hadjeres R, Saad F
Can J Urol 2004 Aug;11(4):2350-1. PMID: 15380057
The growing teratoma syndrome.
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236
The role of surgery in advanced testicular cancer.
Van Dongen JA, ten Bokkel Huinink WW, Van Coevorden SJ, Delemarre JF, Van Hoesel QG
Neth J Surg 1983 Sep;35(4):129-33. PMID: 6195554

Prognosis

Primary and Postchemotherapy Retroperitoneal Lymphadenectomy for Testicular Cancer.
Heidenreich A, Paffenholz P, Nestler T, Pfister D
Oncol Res Treat 2018;41(6):370-378. Epub 2018 May 17 doi: 10.1159/000489508. PMID: 29772568
Diagnosing testicular lumps in primary care.
Stonier T, Simson N, Challacombe B
Practitioner 2017 Apr;261(1803):13-7. PMID: 29020728
Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.
Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916
The growing teratoma syndrome.
Jeffery GM, Theaker JM, Lee AH, Blaquiere RM, Smart CJ, Mead GM
Br J Urol 1991 Feb;67(2):195-202. doi: 10.1111/j.1464-410x.1991.tb15109.x. PMID: 2004236
MRI for evaluation of scrotal pathology.
Schultz-Lampel D, Bogaert G, Thüroff JW, Schlegel E, Cramer B
Urol Res 1991;19(5):289-92. doi: 10.1007/BF00299060. PMID: 1659016

Clinical prediction guides

The potential role of MR based radiomic biomarkers in the characterization of focal testicular lesions.
Feliciani G, Mellini L, Carnevale A, Sarnelli A, Menghi E, Piccinini F, Scarpi E, Loi E, Galeotti R, Giganti M, Parenti GC
Sci Rep 2021 Feb 10;11(1):3456. doi: 10.1038/s41598-021-83023-4. PMID: 33568713Free PMC Article
Incidentally detected testicular lesions <10 mm in diameter: can orchidectomy be avoided?
Scandura G, Verrill C, Protheroe A, Joseph J, Ansell W, Sahdev A, Shamash J, Berney DM
BJU Int 2018 Apr;121(4):575-582. Epub 2017 Nov 12 doi: 10.1111/bju.14056. PMID: 29032579
Efficacy of ultrasound-guided testicle-sparing surgery for small testicular masses.
Dell'Atti L
J Ultrasound 2016 Mar;19(1):29-33. Epub 2015 Jun 23 doi: 10.1007/s40477-015-0171-4. PMID: 26941880Free PMC Article
Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.
Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916
MRI for evaluation of scrotal pathology.
Schultz-Lampel D, Bogaert G, Thüroff JW, Schlegel E, Cramer B
Urol Res 1991;19(5):289-92. doi: 10.1007/BF00299060. PMID: 1659016

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