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PRETEXT III Hepatoblastoma

MedGen UID:
233823
•Concept ID:
C1335257
•
Neoplastic Process
Synonyms: PRETEXT Stage 3 Hepatoblastoma; PRETEXT Stage III Hepatoblastoma

Definition

An internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPRETEXT III Hepatoblastoma

Professional guidelines

PubMed

Successful treatment of young childhood standard-risk hepatoblastoma with cisplatin monotherapy using a central review system.
Saeki I, Ida K, Kurihara S, Watanabe K, Mori M, Hishiki T, Yokoi A, Fujimura J, Honda S, Nogami Y, Iehara T, Kazama T, Sekiguchi M, Kitagawa N, Matsumura R, Nomura M, Yamada Y, Hanaki R, Kaneda H, Takama Y, Inoue T, Tanaka Y, Miyazaki O, Nagase H, Takimoto T, Yoshimura K, Hiyama E
Pediatr Blood Cancer 2024 Nov;71(11):e31255. Epub 2024 Aug 10 doi: 10.1002/pbc.31255. PMID: 39126361
Avoiding liver transplantation in post-treatment extent of disease III and IV hepatoblastoma.
El-Gendi A, Fadel S, El-Shafei M, Shawky A
Pediatr Int 2018 Sep;60(9):862-868. Epub 2018 Aug 9 doi: 10.1111/ped.13634. PMID: 29906299
Efficacy of preoperative transcatheter arterial chemoembolization combined with systemic chemotherapy for treatment of unresectable hepatoblastoma in children.
Hirakawa M, Nishie A, Asayama Y, Fujita N, Ishigami K, Tajiri T, Taguchi T, Honda H
Jpn J Radiol 2014 Sep;32(9):529-36. Epub 2014 Jun 13 doi: 10.1007/s11604-014-0340-y. PMID: 24923584

Recent clinical studies

Etiology

Prognostic Factors for Liver Transplantation in Unresectable Hepatoblastoma.
Triana Junco P, Cano EM, Dore M, Jimenez Gomez J, Sánchez Galán A, Vilanova-Sánchez A, Andres A, Encinas JL, Martinez L, Hernandez F, Lopez Santamaria M
Eur J Pediatr Surg 2019 Feb;29(1):28-32. Epub 2018 Aug 7 doi: 10.1055/s-0038-1668148. PMID: 30086577
Avoiding liver transplantation in post-treatment extent of disease III and IV hepatoblastoma.
El-Gendi A, Fadel S, El-Shafei M, Shawky A
Pediatr Int 2018 Sep;60(9):862-868. Epub 2018 Aug 9 doi: 10.1111/ped.13634. PMID: 29906299
Surgical Resection for Hepatoblastoma-Updated Survival Outcomes.
Sunil BJ, Palaniappan R, Venkitaraman B, Ranganathan R
J Gastrointest Cancer 2018 Dec;49(4):493-496. doi: 10.1007/s12029-017-0005-z. PMID: 28963691
Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.
Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P
Lancet Oncol 2017 Jan;18(1):122-131. Epub 2016 Nov 22 doi: 10.1016/S1470-2045(16)30598-8. PMID: 27884679Free PMC Article
Liver transplantation for hepatoblastoma.
Faraj W, Dar F, Marangoni G, Bartlett A, Melendez HV, Hadzic D, Dhawan A, Mieli-Vergani G, Rela M, Heaton N
Liver Transpl 2008 Nov;14(11):1614-9. doi: 10.1002/lt.21586. PMID: 18975296

Diagnosis

Surgical Management and Outcomes of Patients with Multifocal Hepatoblastoma.
Whitlock RS, Portuondo JI, Espinoza AF, Ortega R, Galván NTN, Leung DH, Lopez-Terrada D, Masand P, Nguyen HN, Patel KA, Goss JA, Heczey AM, Vasudevan SA
J Pediatr Surg 2023 Sep;58(9):1715-1726. Epub 2023 May 8 doi: 10.1016/j.jpedsurg.2023.05.001. PMID: 37244849
Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.
Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P
Lancet Oncol 2017 Jan;18(1):122-131. Epub 2016 Nov 22 doi: 10.1016/S1470-2045(16)30598-8. PMID: 27884679Free PMC Article
Effect of neoadjuvant chemotherapy on resectability of stage III and IV hepatoblastoma.
Venkatramani R, Stein JE, Sapra A, Genyk Y, Jhaveri V, Malogolowkin M, Mascarenhas L
Br J Surg 2015 Jan;102(1):108-13. Epub 2014 Oct 28 doi: 10.1002/bjs.9681. PMID: 25349947
Primary liver tumors in children: Hacettepe experience.
Kutluk T, Yalçın B, Ekinci S, Kale G, Akyüz C, Aydın B, Varan A, Demir HA, Büyükpamukçu M
Turk J Pediatr 2014 Jan-Feb;56(1):1-10. PMID: 24827942
Progress in the surgical treatment of malignant liver tumors in children.
Otte JB
Cancer Treat Rev 2010 Jun;36(4):360-71. Epub 2010 Mar 12 doi: 10.1016/j.ctrv.2010.02.013. PMID: 20227190

Therapy

Avoiding liver transplantation in post-treatment extent of disease III and IV hepatoblastoma.
El-Gendi A, Fadel S, El-Shafei M, Shawky A
Pediatr Int 2018 Sep;60(9):862-868. Epub 2018 Aug 9 doi: 10.1111/ped.13634. PMID: 29906299
Surgical Resection for Hepatoblastoma-Updated Survival Outcomes.
Sunil BJ, Palaniappan R, Venkitaraman B, Ranganathan R
J Gastrointest Cancer 2018 Dec;49(4):493-496. doi: 10.1007/s12029-017-0005-z. PMID: 28963691
Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.
Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P
Lancet Oncol 2017 Jan;18(1):122-131. Epub 2016 Nov 22 doi: 10.1016/S1470-2045(16)30598-8. PMID: 27884679Free PMC Article
Effect of neoadjuvant chemotherapy on resectability of stage III and IV hepatoblastoma.
Venkatramani R, Stein JE, Sapra A, Genyk Y, Jhaveri V, Malogolowkin M, Mascarenhas L
Br J Surg 2015 Jan;102(1):108-13. Epub 2014 Oct 28 doi: 10.1002/bjs.9681. PMID: 25349947
Efficacy of neoadjuvant therapy and surgical rescue for locally advanced hepatoblastomas: 10 year single-center experience and literature review.
Ayllon Teran D, Gómez Beltran O, Ciria Bru R, Mateos González E, Peña Rosa MJ, Luque Molina A, López Cillero P, Briceño Delgado J
World J Gastroenterol 2014 Aug 7;20(29):10137-43. doi: 10.3748/wjg.v20.i29.10137. PMID: 25110441Free PMC Article

Prognosis

Prognostic Factors for Liver Transplantation in Unresectable Hepatoblastoma.
Triana Junco P, Cano EM, Dore M, Jimenez Gomez J, Sánchez Galán A, Vilanova-Sánchez A, Andres A, Encinas JL, Martinez L, Hernandez F, Lopez Santamaria M
Eur J Pediatr Surg 2019 Feb;29(1):28-32. Epub 2018 Aug 7 doi: 10.1055/s-0038-1668148. PMID: 30086577
Avoiding liver transplantation in post-treatment extent of disease III and IV hepatoblastoma.
El-Gendi A, Fadel S, El-Shafei M, Shawky A
Pediatr Int 2018 Sep;60(9):862-868. Epub 2018 Aug 9 doi: 10.1111/ped.13634. PMID: 29906299
Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.
Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P
Lancet Oncol 2017 Jan;18(1):122-131. Epub 2016 Nov 22 doi: 10.1016/S1470-2045(16)30598-8. PMID: 27884679Free PMC Article
Primary liver tumors in children: Hacettepe experience.
Kutluk T, Yalçın B, Ekinci S, Kale G, Akyüz C, Aydın B, Varan A, Demir HA, Büyükpamukçu M
Turk J Pediatr 2014 Jan-Feb;56(1):1-10. PMID: 24827942
Liver transplantation for hepatoblastoma.
Faraj W, Dar F, Marangoni G, Bartlett A, Melendez HV, Hadzic D, Dhawan A, Mieli-Vergani G, Rela M, Heaton N
Liver Transpl 2008 Nov;14(11):1614-9. doi: 10.1002/lt.21586. PMID: 18975296

Clinical prediction guides

Predictors of survival following liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma: Experience from the Society of Pediatric Liver Transplantation (SPLIT).
Boster JM, Superina R, Mazariegos GV, Tiao GM, Roach JP, Lovell MA, Greffe BS, Yanni G, Leung DH, Elisofon SA, McDiarmid SV, Gupta NA, Lobritto SJ, Lemoine C, Stoll JM, Vitola BE, Daniel JF, Sayed BA, Desai DM, Martin AE, Amin A, Anand R, Anderson SG, Sundaram SS
Am J Transplant 2022 May;22(5):1396-1408. Epub 2022 Jan 22 doi: 10.1111/ajt.16945. PMID: 34990053
Tumor rupture in hepatoblastoma: A high risk factor?
Pondrom M, Pariente D, Mallon B, Taque S, Branchereau S, Chardot C, Laithier V, Tabone MD, Lejeune J, Faure-Conter C, Saumet L, Vérité C, Aerts I, Brugières L, Fresneau B
Pediatr Blood Cancer 2020 Sep;67(9):e28549. Epub 2020 Jul 3 doi: 10.1002/pbc.28549. PMID: 32618436
Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.
Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P
Lancet Oncol 2017 Jan;18(1):122-131. Epub 2016 Nov 22 doi: 10.1016/S1470-2045(16)30598-8. PMID: 27884679Free PMC Article
PRETEXT II-III multifocal hepatoblastoma: significance of resection of satellite lesions irrespective of their disappearance after chemotherapy.
Qureshi SS, Bhagat M, Kembhavi S, Vora T, Ramadwar M, Talole S
Pediatr Surg Int 2015 Jun;31(6):573-9. Epub 2015 Apr 23 doi: 10.1007/s00383-015-3713-0. PMID: 25904441
Progress in the surgical treatment of malignant liver tumors in children.
Otte JB
Cancer Treat Rev 2010 Jun;36(4):360-71. Epub 2010 Mar 12 doi: 10.1016/j.ctrv.2010.02.013. PMID: 20227190

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