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Pancreatic signet ring cell adenocarcinoma

MedGen UID:
233834
•Concept ID:
C1335317
•
Neoplastic Process
Synonyms: pancreas signet ring cell carcinoma; pancreatic signet ring cell adenocarcinoma; Pancreatic Signet Ring Cell Carcinoma; pancreatic signet ring cell carcinoma; pancreatic signet Ring cell carcinoma; Pancreatic Signet-Ring Cell Carcinoma; Signet Ring Cell Carcinoma of Pancreas; signet Ring cell carcinoma of pancreas; Signet Ring Cell Carcinoma of the Pancreas; signet Ring cell carcinoma of the pancreas
 
Monarch Initiative: MONDO:0002666

Definition

A rare pancreatic ductal adenocarcinoma with poor prognosis. It is characterized by the presence of malignant signet ring cells infiltrating the pancreatic parenchyma in an individual cell pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic signet ring cell adenocarcinoma

Professional guidelines

PubMed

The Impact of Epidemiological Factors and Treatment Interventions on Survival in Patients With Signet Ring Cell Carcinoma of the Pancreas.
Patel M, Hans HS, Pan K, Khan H, Donath E, Caldera H
Am J Clin Oncol 2018 Dec;41(12):1176-1184. doi: 10.1097/COC.0000000000000447. PMID: 29672365
Vacuolated cell pattern of pancreatobiliary adenocarcinoma: a clinicopathological analysis of 24 cases of a poorly recognized distinctive morphologic variant important in the differential diagnosis.
Dursun N, Feng J, Basturk O, Bandyopadhyay S, Cheng JD, Adsay VN
Virchows Arch 2010 Dec;457(6):643-9. Epub 2010 Oct 8 doi: 10.1007/s00428-010-0978-5. PMID: 20931225Free PMC Article
Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections.
Fan Z, van de Rijn M, Montgomery K, Rouse RV
Mod Pathol 2003 Feb;16(2):137-44. doi: 10.1097/01.MP.0000052103.13730.20. PMID: 12591966

Recent clinical studies

Etiology

Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis.
Zi M, Ma Y, Chen J, Pang C, Li X, Yuan L, Liu Z, Yu P
Cancer Med 2024 Feb;13(4):e7011. doi: 10.1002/cam4.7011. PMID: 38457192Free PMC Article
Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells.
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Prognostic Impact of the Signet Ring Cell Type in Node-Negative Gastric Cancer.
Kong P, Wu R, Yang C, Geng Q, Liu J, Chen S, Liu X, Ye M, He W, Yang Q, Xia L, Xu D
Sci Rep 2016 Jul 6;6:26313. doi: 10.1038/srep26313. PMID: 27381549Free PMC Article
Signet-ring cell carcinoma of the ampulla of Vater.
Li L, Chen QH, Sullivan JD, Breuer FU
Ann Clin Lab Sci 2004 Autumn;34(4):471-5. PMID: 15648791

Diagnosis

Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
An Unusual Cause of Chest Pain.
Nehme F, Atallah R, Palko W
Gastroenterology 2019 Jul;157(1):e13-e14. Epub 2019 Mar 6 doi: 10.1053/j.gastro.2019.02.043. PMID: 30851302
In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature.
Bustamante C, Hoyos-Martínez A, Pirela D, Díaz A
J Pediatr Endocrinol Metab 2017 Jul 26;30(7):785-790. doi: 10.1515/jpem-2016-0433. PMID: 28682787
Metastatic tumours mimicking vestibular schwannoma.
Preuss M, Stein M, Huegens-Penzel M, Kuchelmeister K, Nestler U
Acta Neurochir (Wien) 2008 Sep;150(9):915-9. Epub 2008 Aug 27 doi: 10.1007/s00701-008-0007-5. PMID: 18754073

Therapy

Glycan expression profile of signet ring cell gastric cancer cells and potential applicability of rBC2LCN-targeted lectin drug conjugate therapy.
Yang Y, Akashi Y, Shimomura O, Tateno H, Saito S, Hiemori K, Miyazaki Y, Furuta T, Kitaguchi D, Kuroda Y, Pakavarin L, Oda T
Gastric Cancer 2022 Sep;25(5):896-905. Epub 2022 Jun 17 doi: 10.1007/s10120-022-01312-x. PMID: 35715659
Improving survival of stage II-III primary gastric signet ring cell carcinoma by adjuvant chemoradiotherapy.
Li Y, Zhu Z, Ma F, Xue L, Tian Y
Cancer Med 2020 Sep;9(18):6617-6628. Epub 2020 Aug 3 doi: 10.1002/cam4.3342. PMID: 32744431Free PMC Article
Feasibility study of postoperative adjuvant chemotherapy with S-1 in patients with biliary tract cancer.
Nakachi K, Konishi M, Ikeda M, Shimada K, Okusaka T, Saiura A, Ishii H, Sugiyama M, Furuse J, Sakamoto H, Shimamura T, Ohta T
Int J Clin Oncol 2018 Oct;23(5):894-899. Epub 2018 Apr 28 doi: 10.1007/s10147-018-1283-6. PMID: 29705976
Primary signet ring cell carcinoma of the pancreas with a good response to chemotherapy: case report and literature review.
Radojkovic M, Ilic D, Ilic I
Tumori 2017 Nov 15;103(Suppl. 1):e50-e52. doi: 10.5301/tj.5000671. PMID: 28708232
A man with a testicular mass and a colon stenosis. Diagnosis: Metastatic pancreatic adenocarcinoma to the gonads.
Bornschein J, Kuester D, Mönkemüller K
Gastroenterology 2011 Jul;141(1):37-405. Epub 2011 Jun 1 doi: 10.1053/j.gastro.2010.11.043. PMID: 21640111

Prognosis

Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study.
Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells.
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
An Unusual Cause of Chest Pain.
Nehme F, Atallah R, Palko W
Gastroenterology 2019 Jul;157(1):e13-e14. Epub 2019 Mar 6 doi: 10.1053/j.gastro.2019.02.043. PMID: 30851302
Patient Selection for Cytoreductive Surgery.
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682

Clinical prediction guides

A novel web-based dynamic prognostic nomogram for gastric signet ring cell carcinoma: a multicenter population-based study.
Jiang Y, Hu H, Shao X, Li W, Lu Y, Liang J, Tian Y
Front Immunol 2024;15:1365834. Epub 2024 Apr 10 doi: 10.3389/fimmu.2024.1365834. PMID: 38660300Free PMC Article
Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis.
Zi M, Ma Y, Chen J, Pang C, Li X, Yuan L, Liu Z, Yu P
Cancer Med 2024 Feb;13(4):e7011. doi: 10.1002/cam4.7011. PMID: 38457192Free PMC Article
Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study.
Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Approaches to Biopsy and Resection Specimens from the Ampulla.
Xue Y, Reid MD
Surg Pathol Clin 2020 Sep;13(3):453-467. Epub 2020 Jul 15 doi: 10.1016/j.path.2020.05.005. PMID: 32773194
Patient Selection for Cytoreductive Surgery.
Grotz TE, Fournier KF, Mansfield PF
Surg Oncol Clin N Am 2018 Jul;27(3):443-462. doi: 10.1016/j.soc.2018.02.012. PMID: 29935682

Recent systematic reviews

Invasive lobular carcinoma metastasis to pancreas mimicking pancreatic signet ring cell carcinoma: A case report and systematic review of the literature.
Rossi C, Gallotti A, Messina A, Cobianchi L, Inzani F, Lucioni M, Vanoli A
Pathol Res Pract 2024 Jan;253:155049. Epub 2023 Dec 21 doi: 10.1016/j.prp.2023.155049. PMID: 38176311

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