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Microscopic breast papilloma

MedGen UID:
233851
•Concept ID:
C1335390
•
Neoplastic Process
Synonyms: Breast Peripheral Papilloma; Microscopic Breast Papilloma; microscopic breast papilloma; Peripheral Breast Papilloma; peripheral breast papilloma
 
Monarch Initiative: MONDO:0004506

Definition

A benign papillary neoplasm that arises in a terminal ductal lobular unit. It is characterized by the presence of a fibrovascular core that is lined by benign epithelial and myoepithelial proliferations. Peripheral breast papillomas are often multiple and are usually found microscopically. Patients are often asymptomatic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMicroscopic breast papilloma

Professional guidelines

PubMed

Microcalcification is an important factor in the management of breast intraductal papillomas diagnosed on core biopsy.
Li X, Weaver O, Desouki MM, Dabbs D, Shyum S, Carter G, Zhao C
Am J Clin Pathol 2012 Dec;138(6):789-95. doi: 10.1309/AJCPTDQCHIWH4OHM. PMID: 23161711

Recent clinical studies

Etiology

Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy.
Lee KA, Zuley ML, Chivukula M, Choksi ND, Ganott MA, Sumkin JH
AJR Am J Roentgenol 2012 Feb;198(2):W141-5. doi: 10.2214/AJR.11.7712. PMID: 22268203
Intraductal papilloma: features on MR ductography using a microscopic coil.
Bhattarai N, Kanemaki Y, Kurihara Y, Nakajima Y, Fukuda M, Maeda I
AJR Am J Roentgenol 2006 Jan;186(1):44-7. doi: 10.2214/AJR.04.1600. PMID: 16357375
The ITACARE Study.
Sant M, Gatta G, Valente F, Barchielli A, Ramazzotti V, Serventi L, Rosso S
Tumori 1997 Jan-Feb;83(1):17-24. doi: 10.1177/030089169708300106. PMID: 9152464
Reproducibility and validity of pathologic classifications of benign breast disease and implications for clinical applications.
Bodian CA, Perzin KH, Lattes R, Hoffmann P
Cancer 1993 Jun 15;71(12):3908-13. doi: 10.1002/1097-0142(19930615)71:12<3908::aid-cncr2820711218>3.0.co;2-f. PMID: 8508356
Peritoneal serous micropapillomatosis of low malignant potential (serous borderline tumors of the peritoneum). A clinicopathologic study of 17 cases.
Biscotti CV, Hart WR
Am J Surg Pathol 1992 May;16(5):467-75. doi: 10.1097/00000478-199205000-00005. PMID: 1599025

Diagnosis

Nipple Adenoma: Clinicopathologic Characterization of 50 Cases.
Weigelt MA, Sciallis AP, McIntire PJ, Ko JS, Billings SD, Ronen S
Am J Surg Pathol 2023 Aug 1;47(8):926-932. Epub 2023 Jun 5 doi: 10.1097/PAS.0000000000002063. PMID: 37272622
The Conundrum of Papillary Breast Lesions within the C3 Category.
Weigner J, Zardawi I, Braye S, McElduff P
Acta Cytol 2015;59(4):289-97. Epub 2015 Sep 2 doi: 10.1159/000438817. PMID: 26329503
Swiss cheese disease of the breast: macroscopic appearance of microscopic slides offers a diagnostic clue.
Ozerdem U, Hoda SA
Int J Surg Pathol 2014 Feb;22(1):66-7. Epub 2013 Nov 18 doi: 10.1177/1066896913509012. PMID: 24249844
The ITACARE Study.
Sant M, Gatta G, Valente F, Barchielli A, Ramazzotti V, Serventi L, Rosso S
Tumori 1997 Jan-Feb;83(1):17-24. doi: 10.1177/030089169708300106. PMID: 9152464
On the origin and progression of human breast cancer.
Jensen HM
Am J Obstet Gynecol 1986 Jun;154(6):1280-4. doi: 10.1016/0002-9378(86)90713-1. PMID: 2424309

Therapy

Recurrent syringomatous adenoma of the nipple following a misdiagnosis: A case report.
Abeciunas V, Jurgaitis K, Jakutis N
Niger J Clin Pract 2020 Sep;23(9):1324-1327. doi: 10.4103/njcp.njcp_1_20. PMID: 32913175
Differential diagnosis of oncocytic lesions of the breast and thyroid utilizing a semiquantitative approach.
Nasuti JF, Benedict C, Hurford M, Bibbo M
Acta Cytol 1999 Jul-Aug;43(4):544-51. doi: 10.1159/000331145. PMID: 10432873
Secretory carcinoma of the breast associated with juvenile papillomatosis in a 12-year-old girl. A case report.
Nonomura A, Kimura A, Mizukami Y, Nakamura S, Ohmura K, Watanabe Y, Tanimoto K, Ikegaki S
Acta Cytol 1995 May-Jun;39(3):569-76. PMID: 7762355
Reproducibility and validity of pathologic classifications of benign breast disease and implications for clinical applications.
Bodian CA, Perzin KH, Lattes R, Hoffmann P
Cancer 1993 Jun 15;71(12):3908-13. doi: 10.1002/1097-0142(19930615)71:12<3908::aid-cncr2820711218>3.0.co;2-f. PMID: 8508356
Peritoneal serous micropapillomatosis of low malignant potential (serous borderline tumors of the peritoneum). A clinicopathologic study of 17 cases.
Biscotti CV, Hart WR
Am J Surg Pathol 1992 May;16(5):467-75. doi: 10.1097/00000478-199205000-00005. PMID: 1599025

Prognosis

Next Generation Sequencing in Vitellointestinal Duct Adenoma: Existence of Adenoma-Carcinoma Sequence or too Early to Predict?
Srivastava P, Mishra S, Shukla S, Husain N
Int J Surg Pathol 2023 Oct;31(7):1403-1408. Epub 2023 Feb 19 doi: 10.1177/10668969231152581. PMID: 36803135
Risk of malignancy when microscopic radial scars and microscopic papillomas are found at percutaneous biopsy.
Lee KA, Zuley ML, Chivukula M, Choksi ND, Ganott MA, Sumkin JH
AJR Am J Roentgenol 2012 Feb;198(2):W141-5. doi: 10.2214/AJR.11.7712. PMID: 22268203
The ITACARE Study.
Sant M, Gatta G, Valente F, Barchielli A, Ramazzotti V, Serventi L, Rosso S
Tumori 1997 Jan-Feb;83(1):17-24. doi: 10.1177/030089169708300106. PMID: 9152464
Reproducibility and validity of pathologic classifications of benign breast disease and implications for clinical applications.
Bodian CA, Perzin KH, Lattes R, Hoffmann P
Cancer 1993 Jun 15;71(12):3908-13. doi: 10.1002/1097-0142(19930615)71:12<3908::aid-cncr2820711218>3.0.co;2-f. PMID: 8508356
Subgross physiopathology of the breast associated with clinical cancer.
Sarnelli R, Sabò C, Squartini F
Tumori 1980 Oct 31;66(5):565-82. doi: 10.1177/030089168006600504. PMID: 7466923

Clinical prediction guides

Next Generation Sequencing in Vitellointestinal Duct Adenoma: Existence of Adenoma-Carcinoma Sequence or too Early to Predict?
Srivastava P, Mishra S, Shukla S, Husain N
Int J Surg Pathol 2023 Oct;31(7):1403-1408. Epub 2023 Feb 19 doi: 10.1177/10668969231152581. PMID: 36803135
Diagnostic performance of tomosynthesis, digital mammography and a dedicated digital specimen radiography system versus pathological assessment of excised breast lesions.
Almasarweh S, Sudah M, Okuma H, Joukainen S, Kärjä V, Vanninen R, Masarwah A
Radiol Oncol 2022 Dec 1;56(4):461-470. Epub 2022 Oct 13 doi: 10.2478/raon-2022-0036. PMID: 36226804Free PMC Article
Differential diagnosis of oncocytic lesions of the breast and thyroid utilizing a semiquantitative approach.
Nasuti JF, Benedict C, Hurford M, Bibbo M
Acta Cytol 1999 Jul-Aug;43(4):544-51. doi: 10.1159/000331145. PMID: 10432873
Reproducibility and validity of pathologic classifications of benign breast disease and implications for clinical applications.
Bodian CA, Perzin KH, Lattes R, Hoffmann P
Cancer 1993 Jun 15;71(12):3908-13. doi: 10.1002/1097-0142(19930615)71:12<3908::aid-cncr2820711218>3.0.co;2-f. PMID: 8508356
Juvenile papillomatosis (Swiss cheese disease) of the breast.
Rosen PP, Cantrell B, Mullen DL, DePalo A
Am J Surg Pathol 1980 Feb;4(1):3-12. PMID: 7361994

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