U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atypical breast papilloma

MedGen UID:
233997
•Concept ID:
C1332346
•
Neoplastic Process
Synonyms: Atypical Breast Papilloma; atypical breast papilloma; Breast Atypical Papilloma; Intraductal Breast Papilloma with Atypia
 
Monarch Initiative: MONDO:0004507

Definition

An intraductal papilloma of the breast characterized by the presence of focal epithelial atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical breast papilloma

Professional guidelines

PubMed

Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions.
Lamb LR, Bahl M
AJR Am J Roentgenol 2022 Jan;218(1):186-187. Epub 2021 Jul 21 doi: 10.2214/AJR.21.26340. PMID: 34286593
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Pathological criteria and practical issues in papillary lesions of the breast - a review.
Ni YB, Tse GM
Histopathology 2016 Jan;68(1):22-32. doi: 10.1111/his.12866. PMID: 26768027

Recent clinical studies

Etiology

Updates in the Surgical Management of Benign and High-Risk Breast Lesions.
Marin C, Weiss A, Gooch JC
Clin Breast Cancer 2024 Jun;24(4):278-285. Epub 2023 Dec 21 doi: 10.1016/j.clbc.2023.12.008. PMID: 38171944
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast - review and practical issues.
Ni Y, Tse GM
Semin Diagn Pathol 2022 Sep;39(5):344-354. Epub 2022 Jun 11 doi: 10.1053/j.semdp.2022.06.001. PMID: 35718581
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast - review and practical issues.
Ni Y, Tse GM
Semin Diagn Pathol 2022 Sep;39(5):344-354. Epub 2022 Jun 11 doi: 10.1053/j.semdp.2022.06.001. PMID: 35718581
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Premalignant Disorders of the Breast in Pregnancy and Lactation.
Omranipour R, Alipour S, Ensani F, Nakhlis F
Adv Exp Med Biol 2020;1252:63-72. doi: 10.1007/978-3-030-41596-9_8. PMID: 32816263
Papillary lesions of the breast.
Ibarra JA
Breast J 2006 May-Jun;12(3):237-51. doi: 10.1111/j.1075-122X.2006.00248.x. PMID: 16684322

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Effectiveness of the diagnostic pathway of BLES: could it be safely used as a therapeutic method in selected benign lesions?
Kurtoğlu Özçağlayan Tİ, Özkan Gürdal S, Öznur M, Özçağlayan Ö, Doğru M, Topçu B
Diagn Interv Radiol 2019 Nov;25(6):428-434. doi: 10.5152/dir.2019.18427. PMID: 31650964Free PMC Article
Underestimation of breast cancer in intraductal papillomas treated with vacuum-assisted core needle biopsy.
Hodorowicz-Zaniewska D, Siarkiewicz B, Brzuszkiewicz K, Szpor J
Ginekol Pol 2019;90(3):122-127. doi: 10.5603/GP.2019.0022. PMID: 30950000
A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.
Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE
Cancer Causes Control 2010 Jun;21(6):821-8. Epub 2010 Jan 19 doi: 10.1007/s10552-010-9508-7. PMID: 20084540Free PMC Article
Changed expression of 9-O-acetyl GD3 (CDw60) in benign and atypical proliferative lesions and carcinomas of the human breast.
Gocht A, Rutter G, Kniep B
Histochem Cell Biol 1998 Sep;110(3):217-29. doi: 10.1007/s004180050284. PMID: 9749956

Prognosis

Atypical ductal hyperplasia on core needle biopsy: Surgical outcomes of 200 consecutive cases from a high-volume breast program.
Karwowski P, Lumley D, Stokes D, Pavlica M, Edsall B, Fu S, Francfort J, Cohen B, Capizzi A, Ma ZW, Green A, Kao J
Breast J 2021 Mar;27(3):287-290. Epub 2021 Jan 27 doi: 10.1111/tbj.14170. PMID: 33506606
Management of intraductal papilloma without atypia of the breast diagnosed on core biopsy: Size and sampling matter.
Symbol B, Ricci A Jr
Breast J 2018 Sep;24(5):738-742. Epub 2018 Apr 23 doi: 10.1111/tbj.13052. PMID: 29687535
Sonographic features of histopathologically benign solid breast lesions that have been classified as BI-RADS 4 on sonography.
Taskin F, Koseoglu K, Ozbas S, Erkus M, Karaman C
J Clin Ultrasound 2012 Jun;40(5):261-5. Epub 2012 Apr 17 doi: 10.1002/jcu.21923. PMID: 22508447
Is surgical excision necessary in benign papillary lesions initially diagnosed at core biopsy?
Kil WH, Cho EY, Kim JH, Nam SJ, Yang JH
Breast 2008 Jun;17(3):258-62. Epub 2007 Nov 28 doi: 10.1016/j.breast.2007.10.008. PMID: 18054232
Papillary lesions of the breast with and without atypical ductal hyperplasia: can we accurately predict benign behavior from core needle biopsy?
Agoff SN, Lawton TJ
Am J Clin Pathol 2004 Sep;122(3):440-3. doi: 10.1309/NAPJ-MB0G-XKJC-6PTH. PMID: 15362376

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Upgrade Rate and Predictive Factors for Breast Benign Intraductal Papilloma Diagnosed at Biopsy: A Meta-Analysis.
Zhang X, Liu W, Hai T, Li F
Ann Surg Oncol 2021 Dec;28(13):8643-8650. Epub 2021 Jul 30 doi: 10.1245/s10434-021-10188-7. PMID: 34331160
Papillary lesions of the breast: A systematic evaluation of cytologic parameters.
Jamidi SK, Li JJX, Aphivatanasiri C, Chow MBCY, Chan RCK, Ng JKM, Tsang JY, Tse GM
Cancer Cytopathol 2021 Aug;129(8):649-661. Epub 2021 Feb 9 doi: 10.1002/cncy.22412. PMID: 33561323
Atypical ductal hyperplasia on core needle biopsy: Surgical outcomes of 200 consecutive cases from a high-volume breast program.
Karwowski P, Lumley D, Stokes D, Pavlica M, Edsall B, Fu S, Francfort J, Cohen B, Capizzi A, Ma ZW, Green A, Kao J
Breast J 2021 Mar;27(3):287-290. Epub 2021 Jan 27 doi: 10.1111/tbj.14170. PMID: 33506606
Is surgical excision necessary in benign papillary lesions initially diagnosed at core biopsy?
Kil WH, Cho EY, Kim JH, Nam SJ, Yang JH
Breast 2008 Jun;17(3):258-62. Epub 2007 Nov 28 doi: 10.1016/j.breast.2007.10.008. PMID: 18054232

Recent systematic reviews

High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis.
Forester ND, Lowes S, Mitchell E, Twiddy M
Eur J Surg Oncol 2019 Apr;45(4):519-527. Epub 2018 Dec 11 doi: 10.1016/j.ejso.2018.12.008. PMID: 30579653

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...