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Extragastrointestinal Gastrointestinal Stromal Tumor

MedGen UID:
234242
•Concept ID:
C1333500
•
Neoplastic Process
Synonym: Extragastrointestinal Stromal Tumor

Definition

A rare gastrointestinal stromal tumor that presents as a solitary mass outside the gastrointestinal tract. [from NCI]

Professional guidelines

PubMed

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour.
Priya V, Kumari N, Krishnani N
Turk Patoloji Derg 2020;36(2):116-125. doi: 10.5146/tjpath.2019.01470. PMID: 31538651Free PMC Article
Primary extragastrointestinal stromal tumors: a clinicopathological and immunohistochemical study - a tertiary care center experience.
Patnayak R, Jena A, Parthasarathy S, Prasad PD, Reddy MK, Chowhan AK, Rukamangadha N, Phaneendra BV
Indian J Cancer 2013 Jan-Mar;50(1):41-5. doi: 10.4103/0019-509X.112298. PMID: 23713043
The GIST paradigm: how to establish diagnostic and prognostic criteria.
Calabuig-Farinas S, Lopez-Guerrero JA, Llombart-Bosch A
Arkh Patol 2011 Jul-Aug;73(4):13-21. PMID: 22164425

Recent clinical studies

Etiology

Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
The GIST paradigm: how to establish diagnostic and prognostic criteria.
Calabuig-Farinas S, Lopez-Guerrero JA, Llombart-Bosch A
Arkh Patol 2011 Jul-Aug;73(4):13-21. PMID: 22164425
Gastrointestinal stromal tumors and extra-gastrointestinal tract neoplasms.
AbdullGaffar B
South Med J 2010 Oct;103(10):1004-8. doi: 10.1097/SMJ.0b013e3181ef2f41. PMID: 20818304
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Primary prostatic extragastrointestinal stromal tumor: a case report and literature review.
You YH, Zhang Y
J Int Med Res 2018 Oct;46(10):4343-4349. Epub 2018 Aug 28 doi: 10.1177/0300060518791677. PMID: 30152251Free PMC Article
Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Extra-gastrointestinal stromal tumor of the pancreas: case report and review of the literature.
Beltrame V, Gruppo M, Pastorelli D, Pizzi S, Merigliano S, Sperti C
World J Surg Oncol 2014 Apr 23;12:105. doi: 10.1186/1477-7819-12-105. PMID: 24755359Free PMC Article
Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes.
Padhi S, Sarangi R, Mallick S
JOP 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293. PMID: 23306329
Extragastrointestinal stromal tumor arising in the pancreas: a case report with a review of the literature.
Padhi S, Kongara R, Uppin SG, Uppin MS, Prayaga AK, Challa S, Nagari B, Regulagadda SA
JOP 2010 May 5;11(3):244-8. PMID: 20442520

Therapy

Diffuse primary extra-gastrointestinal stromal tumor of the peritoneum: A rare case report.
Lu LJ, Xu XP, Dong F, Min J
Medicine (Baltimore) 2020 Oct 2;99(40):e22493. doi: 10.1097/MD.0000000000022493. PMID: 33019445Free PMC Article
Extraintestinal gastrointestinal stromal tumor of undetermined origin: Is the mass resection a wrong approach? A case report and review of the literature.
Yüksel ÖH, Akan S, Yildirim Ç, Ürkmez A, Verit A
Arch Ital Urol Androl 2015 Jul 7;87(2):177-8. doi: 10.4081/aiua.2015.2.177. PMID: 26150044
An unexpected but interesting response to a novel therapy for malignant extragastrointestinal stromal tumor of the mesoileum: a case report and review of the literature.
Li H, Li J, Li X, Kang Y, Wei Q
World J Surg Oncol 2013 Aug 5;11(1):174. doi: 10.1186/1477-7819-11-174. PMID: 23915013Free PMC Article
Malignant extra-gastrointestinal stromal tumor of the pancreas. A case report and review of literature.
Vij M, Agrawal V, Pandey R
JOP 2011 Mar 9;12(2):200-4. PMID: 21386653
Liver transplantation for metastasized extragastrointestinal stromal tumor: a case report and an overview of literature.
Frilling A, Malago M, Testa G, Schleyer E, Grabellus F, Kronenberger R, Li J, Broelsch CE
Transplant Proc 2010 Nov;42(9):3843-8. doi: 10.1016/j.transproceed.2010.06.016. PMID: 21094867

Prognosis

Extra-gastrointestinal stromal tumor of the pancreas: case report and review of the literature.
Beltrame V, Gruppo M, Pastorelli D, Pizzi S, Merigliano S, Sperti C
World J Surg Oncol 2014 Apr 23;12:105. doi: 10.1186/1477-7819-12-105. PMID: 24755359Free PMC Article
The primary extra-gastrointestinal stromal tumor of pleura: a case report and a literature review.
Yi JH, Sim J, Park BB, Lee YY, Jung WS, Jang HJ, Ha TK, Paik SS
Jpn J Clin Oncol 2013 Dec;43(12):1269-72. Epub 2013 Oct 29 doi: 10.1093/jjco/hyt158. PMID: 24168806
The GIST paradigm: how to establish diagnostic and prognostic criteria.
Calabuig-Farinas S, Lopez-Guerrero JA, Llombart-Bosch A
Arkh Patol 2011 Jul-Aug;73(4):13-21. PMID: 22164425
Extragastrointestinal stromal tumor arising in the rectovaginal septum: report of an unusual case with literature review.
Zhang W, Peng Z, Xu L
Gynecol Oncol 2009 Jun;113(3):399-401. Epub 2009 Mar 17 doi: 10.1016/j.ygyno.2009.02.019. PMID: 19297012
Gastrointestinal stromal tumors: pathology and prognosis at different sites.
Miettinen M, Lasota J
Semin Diagn Pathol 2006 May;23(2):70-83. doi: 10.1053/j.semdp.2006.09.001. PMID: 17193820

Clinical prediction guides

Extra-Gastrointestinal Stromal Tumor of Prostate.
Etit D, Kar H, Ekinci N, Yenipazar AE, Çakalağaoğlu F
Balkan Med J 2017 Apr 5;34(2):168-171. doi: 10.4274/balkanmedj.2015.1331. PMID: 28418346Free PMC Article
Extraintestinal gastrointestinal stromal tumor of undetermined origin: Is the mass resection a wrong approach? A case report and review of the literature.
Yüksel ÖH, Akan S, Yildirim Ç, Ürkmez A, Verit A
Arch Ital Urol Androl 2015 Jul 7;87(2):177-8. doi: 10.4081/aiua.2015.2.177. PMID: 26150044
Retrospective analysis of extra-gastrointestinal stromal tumors.
Yi JH, Park BB, Kang JH, Hwang IG, Shin DB, Sym SJ, Ahn HK, Lee SI, Lim DH, Park KW, Won YW, Lim SH, Park SH
World J Gastroenterol 2015 Feb 14;21(6):1845-50. doi: 10.3748/wjg.v21.i6.1845. PMID: 25684950Free PMC Article
Tumor sites and microscopic indicators are independent prognosis predictors of gastrointestinal stromal tumors.
Qi Y, Zhao W, Wang Z, Li T, Meng X
Tohoku J Exp Med 2014 May;233(1):65-72. doi: 10.1620/tjem.233.65. PMID: 24827382
Malignant extragastrointestinal stromal tumor presenting as a vaginal mass: report of an unusual case with literature review.
Weppler EH, Gaertner EM
Int J Gynecol Cancer 2005 Nov-Dec;15(6):1169-72. doi: 10.1111/j.1525-1438.2005.00269.x. PMID: 16343205

Recent systematic reviews

Primary Pancreatic GIST - A-Single Centre Case Series and Systematic Review of Literature.
Gupta V, Chopde A, Chaudhari V, Bal M, Shrikhande SV, Bhandare MS
J Gastrointest Cancer 2024 Jun;55(2):572-583. Epub 2024 Feb 7 doi: 10.1007/s12029-024-01024-8. PMID: 38324136
Primary hepatic gastrointestinal stromal tumor with right adrenal gland invasion: A case report and systematic literature review.
Xu L, Zhang M, Xu M
Medicine (Baltimore) 2019 May;98(20):e15482. doi: 10.1097/MD.0000000000015482. PMID: 31096446Free PMC Article
Pancreatic extragastrointestinal stromal tumors, interstitial Cajal like cells, and telocytes.
Padhi S, Sarangi R, Mallick S
JOP 2013 Jan 10;14(1):1-14. doi: 10.6092/1590-8577/1293. PMID: 23306329

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