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Head and Neck Basaloid Squamous Cell Carcinoma

MedGen UID:
234337
•Concept ID:
C1333940
•
Neoplastic Process
Synonyms: Basaloid Squamous Cell Carcinoma of Head and Neck; Basaloid Squamous Cell Carcinoma of the Head and Neck; Head and Neck Basaloid Carcinoma

Definition

A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region. The most common sites of origin are pyriform sinus, epiglottis, and base of tongue. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. [from NCI]

Professional guidelines

PubMed

The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.
Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914

Recent clinical studies

Etiology

Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases.
Xie C, Liao J, Huang C, Wei F, Liu T, Wen W, Sun W
Eur Arch Otorhinolaryngol 2022 Apr;279(4):2099-2107. Epub 2021 Jul 28 doi: 10.1007/s00405-021-07007-w. PMID: 34319483
HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Basaloid squamous cell carcinoma of the head and neck: a clinicopathologic and flow cytometric study of 10 new cases with review of the English literature.
Raslan WF, Barnes L, Krause JR, Contis L, Killeen R, Kapadia SB
Am J Otolaryngol 1994 May-Jun;15(3):204-11. doi: 10.1016/0196-0709(94)90006-x. PMID: 8024109

Diagnosis

HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Basaloid squamous cell carcinoma of the head and neck.
Zbären P, Nuyens M, Stauffer E
Curr Opin Otolaryngol Head Neck Surg 2004 Apr;12(2):116-21. doi: 10.1097/00020840-200404000-00011. PMID: 15167048
Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis.
Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C
Ann Otol Rhinol Laryngol 1996 Jan;105(1):75-82. doi: 10.1177/000348949610500115. PMID: 8546432

Therapy

Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Basaloid squamous cell carcinoma of the oral cavity: an analysis of 92 cases.
Fritsch VA, Gerry DR, Lentsch EJ
Laryngoscope 2014 Jul;124(7):1573-8. Epub 2014 Apr 29 doi: 10.1002/lary.24384. PMID: 23946211
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315
Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis.
Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C
Ann Otol Rhinol Laryngol 1996 Jan;105(1):75-82. doi: 10.1177/000348949610500115. PMID: 8546432

Clinical prediction guides

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma.
Prieto-Granada CN, Xu B, Alzumaili B, Al Rasheed MRH, Eskander A, Enepekides D, Patel SG, Stevens TM, Dogan S, Ghossein R, Katabi N
Virchows Arch 2021 Oct;479(4):729-739. Epub 2021 May 12 doi: 10.1007/s00428-021-03117-2. PMID: 33982148Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology.
Jayasooriya PR, Tilakaratne WM, Mendis BR, Lombardi T
Ann Diagn Pathol 2013 Dec;17(6):547-51. Epub 2013 Oct 21 doi: 10.1016/j.anndiagpath.2013.09.001. PMID: 24157420
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent systematic reviews

Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo-Induction: A Case Report and Systematic Review.
Alsavaf MB, Abouammo MD, Bhuskute GS, Sun S, Issa M, Seim NB, VanKoevering KK, Bhateja P, Bonomi M, Carrau RL
Laryngoscope 2024 Sep;134(9):3892-3902. Epub 2024 Apr 23 doi: 10.1002/lary.31426. PMID: 38651346
Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma-An Even Broader Tumor Entity?
Zupancic M, Näsman A
Viruses 2021 Sep 17;13(9) doi: 10.3390/v13091861. PMID: 34578442Free PMC Article
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

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