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Tall cell variant thyroid gland papillary carcinoma

MedGen UID:
234416
•Concept ID:
C1336695
•
Neoplastic Process
Synonyms: Tall Cell Variant Papillary Carcinoma; tall cell variant papillary carcinoma; Tall Cell Variant Thyroid Gland Papillary Carcinoma; tall cell variant thyroid gland papillary carcinoma
 
Monarch Initiative: MONDO:0004103

Definition

A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of tall malignant follicular cells, arranged in papillary and trabecular patterns. Necrotic changes and high mitotic activity are present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTall cell variant thyroid gland papillary carcinoma

Professional guidelines

PubMed

Management of pediatric papillary thyroid cancer.
Pazaitou-Panayiotou K
Hell J Nucl Med 2023 May-Aug;26 Suppl:60-64. PMID: 37658567
Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma.
Cartwright S, Fingeret A
Curr Opin Endocrinol Diabetes Obes 2020 Oct;27(5):351-357. doi: 10.1097/MED.0000000000000559. PMID: 32701516
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article

Recent clinical studies

Etiology

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma.
Cartwright S, Fingeret A
Curr Opin Endocrinol Diabetes Obes 2020 Oct;27(5):351-357. doi: 10.1097/MED.0000000000000559. PMID: 32701516
Prognostic Parameters in Differentiated Thyroid Carcinomas.
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Tall Cell Variant Papillary Thyroid Carcinoma in Saudi Patients: A clinicopathological and Outcomes Analysis.
Al-Qahtani KH, Tunio MA, Al Asiri M, Bayoumi Y, Alshehri WA, Aljohani NJ, Ali AA, Fatani H
Saudi Med J 2016 Nov;37(11):1220-1224. doi: 10.15537/smj.2016.11.15480. PMID: 27761560Free PMC Article

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma.
Cartwright S, Fingeret A
Curr Opin Endocrinol Diabetes Obes 2020 Oct;27(5):351-357. doi: 10.1097/MED.0000000000000559. PMID: 32701516
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology.
Wang X, Cheng W, Liu C, Li J
Oncotarget 2016 Jun 28;7(26):40792-40799. doi: 10.18632/oncotarget.8215. PMID: 27008708Free PMC Article
Papillary thyroid carcinoma variants.
Lloyd RV, Buehler D, Khanafshar E
Head Neck Pathol 2011 Mar;5(1):51-6. Epub 2011 Jan 8 doi: 10.1007/s12105-010-0236-9. PMID: 21221869Free PMC Article

Therapy

Effect of Radioactive Iodine Therapy on Cancer-Specific Survival of Papillary Thyroid Cancer Tall Cell Variant.
Dai P, Zhao W, Zheng X, Luo H, Wang X
J Clin Endocrinol Metab 2024 Feb 20;109(3):e1260-e1266. doi: 10.1210/clinem/dgad580. PMID: 37804527
Large (>4 cm) Intrathyroidal Encapsulated Well-Differentiated Follicular Cell-Derived Carcinoma Without Vascular Invasion May Have Negligible Risk of Recurrence Even When Treated with Lobectomy Alone.
Ghossein R, Ganly I, Tuttle RM, Xu B
Thyroid 2023 May;33(5):586-592. Epub 2023 Apr 18 doi: 10.1089/thy.2023.0032. PMID: 36884299Free PMC Article
Tall cell variant papillary thyroid carcinoma impacts disease-free survival at the 10 % cut-point on multivariate analysis.
Samankan S, Militello L, Seo G, Everest S, O'Malley Q, Spaulding SL, Xing M, Matloob A, Beute J, Chai R, Doyle S, Urken ML, Brandwein-Weber M
Pathol Res Pract 2022 Aug;236:154012. Epub 2022 Jul 2 doi: 10.1016/j.prp.2022.154012. PMID: 35834884
Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma.
Xia F, Jiang B, Chen Y, Du X, Peng Y, Wang W, Wang Z, Li X
Medicine (Baltimore) 2018 Dec;97(51):e13802. doi: 10.1097/MD.0000000000013802. PMID: 30572540Free PMC Article
Papillary thyroid carcinoma tall cell variant.
Ghossein R, Livolsi VA
Thyroid 2008 Nov;18(11):1179-81. doi: 10.1089/thy.2008.0164. PMID: 18925842

Prognosis

Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children.
Slack JC, Hollowell M, Barletta JA
Endocr Pathol 2023 Jun;34(2):165-175. Epub 2023 May 9 doi: 10.1007/s12022-023-09764-2. PMID: 37160531
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma.
Cartwright S, Fingeret A
Curr Opin Endocrinol Diabetes Obes 2020 Oct;27(5):351-357. doi: 10.1097/MED.0000000000000559. PMID: 32701516
Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.
Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657Free PMC Article
Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology.
Wang X, Cheng W, Liu C, Li J
Oncotarget 2016 Jun 28;7(26):40792-40799. doi: 10.18632/oncotarget.8215. PMID: 27008708Free PMC Article

Clinical prediction guides

HIF-1α and Caspase-3 expression in aggressive papillary thyroid carcinoma.
Zhang L, Shi B, Hu M, Qian L
World J Surg Oncol 2022 Nov 4;20(1):353. doi: 10.1186/s12957-022-02815-8. PMID: 36329448Free PMC Article
Papillary thyroid microcarcinomas: does subtyping predict aggressive clinical behavior?
Gubbiotti MA, Livolsi V, Montone K, Baloch Z
Hum Pathol 2021 Aug;114:28-35. Epub 2021 May 7 doi: 10.1016/j.humpath.2021.04.015. PMID: 33971214
Prognostic Parameters in Differentiated Thyroid Carcinomas.
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
The tall cell variant of papillary thyroid carcinoma: clinical and pathological features and outcomes.
Regalbuto C, Malandrino P, Frasca F, Pellegriti G, Le Moli R, Vigneri R, Pezzino V
J Endocrinol Invest 2013 Apr;36(4):249-54. Epub 2012 Jul 9 doi: 10.3275/8515. PMID: 22776915

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