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Thymus gland adenocarcinoma

MedGen UID:
234426
•Concept ID:
C1336743
•
Neoplastic Process
Synonyms: Adenocarcinoma of the Thymus; adenocarcinoma of the Thymus; Adenocarcinoma of Thymus; adenocarcinoma of Thymus; Thymic Adenocarcinoma; thymic adenocarcinoma; Thymus Adenocarcinoma; Thymus adenocarcinoma; thymus adenocarcinoma; thymus gland adenocarcinoma
 
Monarch Initiative: MONDO:0003209

Definition

A rare primary thymic carcinoma, characterized by the presence of carcinoma cells with glandular differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymus gland adenocarcinoma

Professional guidelines

PubMed

Treatment, prognostic markers and survival in thymic neuroendocrine tumours. a study from a single tertiary referral centre.
Crona J, Björklund P, Welin S, Kozlovacki G, Oberg K, Granberg D
Lung Cancer 2013 Mar;79(3):289-93. Epub 2013 Jan 1 doi: 10.1016/j.lungcan.2012.12.001. PMID: 23286964
Mediastinal images resembling thymus following 131-I treatment for thyroid cancer.
Montella L, Caraglia M, Abbruzzese A, Soricelli A, Caputi M, Squame G, Salvatore M, Del Prete S, Palmieri G
Monaldi Arch Chest Dis 2005 Jun;63(2):114-7. doi: 10.4081/monaldi.2005.649. PMID: 16128228
The fine structure of thymoma, with emphasis on its differential diagnosis. A study of ten cases.
Levine GD, Rosai J, Bearman RM, Polliack A
Am J Pathol 1975 Oct;81(1):49-86. PMID: 1080957Free PMC Article

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
New therapies for patients with multiple endocrine neoplasia type 1.
Geslot A, Vialon M, Caron P, Grunenwald S, Vezzosi D
Ann Endocrinol (Paris) 2021 Apr;82(2):112-120. Epub 2021 Apr 8 doi: 10.1016/j.ando.2021.03.005. PMID: 33839123
Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.
Zhou P, Fang X, McNally BA, Yu P, Zhu M, Fu YX, Wang L, Liu Y, Zheng P
Proc Natl Acad Sci U S A 2009 Oct 6;106(40):17134-9. Epub 2009 Sep 23 doi: 10.1073/pnas.0905707106. PMID: 19805094Free PMC Article
Radiogenic male breast cancer with in vitro sensitivity to ionizing radiation and bleomycin.
Greene MH, Goedert JJ, Bech-Hansen NT, McGuire D, Paterson MC, Fraumeni JF Jr
Cancer Invest 1983;1(5):379-86. doi: 10.3109/07357908309048506. PMID: 6199096
Thyroid carcinoma and radiation. A Chicago endemic.
DeGroot L, Paloyan E
JAMA 1973 Jul 30;225(5):487-91. PMID: 4740336

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Appearance of a thymic mass after treatment of Cushing's syndrome.
Delitala AP, Olita L, Piras C, Cosseddu R, Bagella G, Fanciulli G
Asian Cardiovasc Thorac Ann 2017 Feb;25(2):150-153. Epub 2016 Dec 19 doi: 10.1177/0218492316686480. PMID: 28183214
Carcinoid tumor.
Kinova S, Duris I
Bratisl Lek Listy 2001;102(11):495-504. PMID: 11901706
Carcinoid tumors and oat cell carcinomas of the thymus.
Rosai J, Levine G, Weber WR, Higa E
Pathol Annu 1976;11:201-26. PMID: 188002
Primary immunodeficiency diseases and malignancy.
Shackleford MD, McAlister WH
Am J Roentgenol Radium Ther Nucl Med 1975 Jan;123(1):144-53. doi: 10.2214/ajr.123.1.144. PMID: 47231

Therapy

Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature.
Singh A, Pandey KC, Pant NK
J Cancer Res Ther 2010 Jul-Sep;6(3):350-2. doi: 10.4103/0973-1482.73363. PMID: 21119274
Epidemiology of non-gastroenteropancreatic (neuro)endocrine tumours.
Ferolla P, Faggiano A, Avenia N, Milone F, Masone S, Giampaglia F, Puma F, Daddi G, Angeletti G, Lombardi G, Santeusanio F, Colao A
Clin Endocrinol (Oxf) 2007 Jan;66(1):1-6. doi: 10.1111/j.1365-2265.2006.02739.x. PMID: 17201794
Carcinoid tumor.
Kinova S, Duris I
Bratisl Lek Listy 2001;102(11):495-504. PMID: 11901706
Normal thymic uptake of 2-deoxy-2[F-18]fluoro-D-glucose.
Alibazoglu H, Alibazoglu B, Hollinger EF, Ingram SA, Willoughby WA, LaMonica G, Ali A
Clin Nucl Med 1999 Aug;24(8):597-600. doi: 10.1097/00003072-199908000-00011. PMID: 10439182
New high-resolution ultrasound evaluation of diseases of the thyroid gland. A review article.
Cole-Beuglet C, Goldberg BB
JAMA 1983 Jun 3;249(21):2941-4. PMID: 6341650

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Appearance of a thymic mass after treatment of Cushing's syndrome.
Delitala AP, Olita L, Piras C, Cosseddu R, Bagella G, Fanciulli G
Asian Cardiovasc Thorac Ann 2017 Feb;25(2):150-153. Epub 2016 Dec 19 doi: 10.1177/0218492316686480. PMID: 28183214
Primary Salivary Gland Type Tumors of the Thymus.
Kalhor N, Weissferdt A, Moran CA
Adv Anat Pathol 2017 Jan;24(1):15-23. doi: 10.1097/PAP.0000000000000132. PMID: 27941539
Epidemiology of non-gastroenteropancreatic (neuro)endocrine tumours.
Ferolla P, Faggiano A, Avenia N, Milone F, Masone S, Giampaglia F, Puma F, Daddi G, Angeletti G, Lombardi G, Santeusanio F, Colao A
Clin Endocrinol (Oxf) 2007 Jan;66(1):1-6. doi: 10.1111/j.1365-2265.2006.02739.x. PMID: 17201794
Multiple endocrine neoplastic-associated thymic carcinoid tumour in close relatives: octreotide scan as a new diagnostic and follow-up modality. Two case reports.
Satta J, Ahonen A, Parkkila S, Leinonen L, Apaja-Sarkkinen M, Lepojärvi M, Juvonen T
Scand Cardiovasc J 1999;33(1):49-53. doi: 10.1080/14017439950142046. PMID: 10093860

Clinical prediction guides

Appearance of a thymic mass after treatment of Cushing's syndrome.
Delitala AP, Olita L, Piras C, Cosseddu R, Bagella G, Fanciulli G
Asian Cardiovasc Thorac Ann 2017 Feb;25(2):150-153. Epub 2016 Dec 19 doi: 10.1177/0218492316686480. PMID: 28183214
Ectopic thymoma can mimic benign and malignant thyroid lesions on fine needle aspiration cytology: a case report and literature review.
Taweevisit M, Sampatanukul P, Thorner PS
Acta Cytol 2013;57(2):213-20. Epub 2013 Feb 28 doi: 10.1159/000346705. PMID: 23406665
Thymic carcinoid with cutaneous hyperpigmentation.
Lieske TR, Kincaid J, Sunderrajan EV
Arch Intern Med 1985 Feb;145(2):361-3. PMID: 3977500
Thymomas.
LeGolvan DP, Abell MR
Cancer 1977 May;39(5):2142-57. doi: 10.1002/1097-0142(197705)39:5<2142::aid-cncr2820390531>3.0.co;2-q. PMID: 558046
Metastatic spread of human tumour implanted into thymectomized, antithymocyte serum treated hamsters.
Cobb LM
Br J Cancer 1972 Jun;26(3):183-9. doi: 10.1038/bjc.1972.25. PMID: 5047142Free PMC Article

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