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Vulvar adenocarcinoma

MedGen UID:
234480
•Concept ID:
C1336975
•
Neoplastic Process
Synonyms: Adenocarcinoma of the Vulva; Adenocarcinoma of the vulva; adenocarcinoma of the vulva; Adenocarcinoma of Vulva; adenocarcinoma of vulva; mammalian vulva adenocarcinoma; vulva adenocarcinoma; Vulvar Adenocarcinoma; vulvar adenocarcinoma
 
HPO: HP:0030420
Monarch Initiative: MONDO:0024336
Orphanet: ORPHA494454

Definition

An adenocarcinoma arising in the vulva. [from HPO]

Professional guidelines

PubMed

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
The management of Paget's disease of the vulva.
MacLean AB, Makwana M, Ellis PE, Cunnington F
J Obstet Gynaecol 2004 Feb;24(2):124-8. doi: 10.1080/01443610410001645370. PMID: 14766444

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

Recent clinical studies

Etiology

Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity.
Moscoso O, Reques A, Saco A, Castellví J, Gómez-Hidalgo NR, Ramón Y Cajal S, García Á
Int J Gynecol Pathol 2022 Jan 1;41(1):98-103. doi: 10.1097/PGP.0000000000000784. PMID: 33782341
Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors(✰).
Desouki MM, Fadare O
Semin Diagn Pathol 2021 Jan;38(1):71-84. Epub 2020 Sep 25 doi: 10.1053/j.semdp.2020.09.011. PMID: 33032903
Clinical characteristics and risk factors of invasion in extramammary Paget's disease of the vulva.
Liang S, Wang J, Wang H, Ren Y
Arch Gynecol Obstet 2021 Feb;303(2):541-546. Epub 2020 Sep 29 doi: 10.1007/s00404-020-05803-z. PMID: 32990781
Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision.
Fanning J, Lambert HC, Hale TM, Morris PC, Schuerch C
Am J Obstet Gynecol 1999 Jan;180(1 Pt 1):24-7. doi: 10.1016/s0002-9378(99)70143-2. PMID: 9914572

Diagnosis

Diagnosis and management of primary vulvar adenocarcinoma of mammary gland type: report of two distinct cases.
Morais M, Vaz Silva J, Tavares MV
BMJ Case Rep 2022 Jun 7;15(6) doi: 10.1136/bcr-2021-245580. PMID: 35672058Free PMC Article
Vulvar Adenocarcinoma With Neuroendocrine Differentiation: A Case Report.
Gabrilovich S, Cracchiolo B, Heller DS
J Low Genit Tract Dis 2017 Apr;21(2):e23-e25. doi: 10.1097/LGT.0000000000000294. PMID: 28157827
FDG-PET/CT of Vulvar Adenocarcinoma With Diffuse Metastases.
Patel D, Anderson TM, Lu Y
Clin Nucl Med 2016 Sep;41(9):710-1. doi: 10.1097/RLU.0000000000001257. PMID: 27187733
Vulvar adenocarcinoma: visual resemblance to a vulvar abscess.
Pandey KC, Revannasiddaiah S, Nautiyal V, Pant NK
BMJ Case Rep 2013 Jun 10;2013 doi: 10.1136/bcr-2013-010365. PMID: 23761517Free PMC Article
Extramammary Paget's disease: Summary of current knowledge.
Lam C, Funaro D
Dermatol Clin 2010 Oct;28(4):807-26. doi: 10.1016/j.det.2010.08.002. PMID: 20883922

Therapy

Vulvar adenocarcinoma: visual resemblance to a vulvar abscess.
Pandey KC, Revannasiddaiah S, Nautiyal V, Pant NK
BMJ Case Rep 2013 Jun 10;2013 doi: 10.1136/bcr-2013-010365. PMID: 23761517Free PMC Article
Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma.
Huang GS, Juretzka M, Ciaravino G, Kohler S, Teng NN
Gynecol Oncol 2002 Dec;87(3):313-8. doi: 10.1006/gyno.2002.6830. PMID: 12468332

Prognosis

Primary vulvar adenocarcinoma of intestinal type: Report of two cases showing molecular similarity with colorectal adenocarcinoma.
Mateoiu C, Palicelli A, Maloberti T, De Biase D, De Leo A, Lindh M, Bohlin KS, Stolnicu S
Pathol Res Pract 2024 Mar;255:155181. Epub 2024 Feb 1 doi: 10.1016/j.prp.2024.155181. PMID: 38340583
Vulvar Adenocarcinoma of Intestinal Type: A Case Report of an Uncommon Entity.
Moscoso O, Reques A, Saco A, Castellví J, Gómez-Hidalgo NR, Ramón Y Cajal S, García Á
Int J Gynecol Pathol 2022 Jan 1;41(1):98-103. doi: 10.1097/PGP.0000000000000784. PMID: 33782341
Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Vulvar adenocarcinoma: visual resemblance to a vulvar abscess.
Pandey KC, Revannasiddaiah S, Nautiyal V, Pant NK
BMJ Case Rep 2013 Jun 10;2013 doi: 10.1136/bcr-2013-010365. PMID: 23761517Free PMC Article
Extramammary Paget's disease: Summary of current knowledge.
Lam C, Funaro D
Dermatol Clin 2010 Oct;28(4):807-26. doi: 10.1016/j.det.2010.08.002. PMID: 20883922

Clinical prediction guides

Characteristics and outcomes of women with adenocarcinoma versus squamous cell carcinoma of the vulva: A Japanese Gynecologic Oncology Group study.
Nishio S, Matsuo K, Matsuzaki S, Kato T, Kamiura S, Adachi H, Okadome M, Nakamura T, Mikami M, Enomoto T
Eur J Surg Oncol 2021 Dec;47(12):3188-3193. Epub 2021 Jul 9 doi: 10.1016/j.ejso.2021.07.002. PMID: 34256962
Primary Clear Cell Adenocarcinoma of the Vulva: A Case Study With Mutation Analysis and Literature Review.
Kojima N, Yoshida H, Uehara T, Ushigusa T, Asami Y, Shiraishi K, Kato T
Int J Surg Pathol 2019 Oct;27(7):792-797. Epub 2019 May 20 doi: 10.1177/1066896919848823. PMID: 31104528
Liposomal doxorubicin for treatment of metastatic chemorefractory vulvar adenocarcinoma.
Huang GS, Juretzka M, Ciaravino G, Kohler S, Teng NN
Gynecol Oncol 2002 Dec;87(3):313-8. doi: 10.1006/gyno.2002.6830. PMID: 12468332

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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