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Pagetoid Reticulosis

MedGen UID:: 234569
•Concept ID:: C1367970
•: Neoplastic Process

Synonyms:	Disease, Woringer Kolopp; Disease, Woringer-Kolopp; Kolopp Disease, Woringer; Pagetoid Reticuloses; Reticuloses, Pagetoid; Reticulosis, Pagetoid; Woringer Kolopp Disease; Woringer-Kolopp Disease
SNOMED CT:	Pagetoid reticulosis (404119000); Pagetoid reticulosis (419386004)

Definition

A variant of mycosis fungoides, characterized by an exclusively intraepidermal atypical (cerebriform) lymphocytic infiltrate. Patients present with a localized psoriasiform or hyperkeratotic patch or plaque, usually in the extremities. Extracutaneous dissemination of the disease has never been reported. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPagetoid Reticulosis

Lymphoma
- Non-Hodgkin lymphoma
  - Non-Hodgkin Lymphoma by Clinical Course
    - Indolent Non-Hodgkin Lymphoma
      - Indolent T-Cell Non-Hodgkin Lymphoma
        Mycosis fungoides
        Pagetoid Reticulosis

Recent clinical studies

Etiology

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.

Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962

Characteristics and outcomes of 727 patients with mycosis fungoides and Sézary syndrome from a Brazilian cohort.

Miyashiro D, Sanches JA
Int J Dermatol 2022 Apr;61(4):442-454. Epub 2021 Aug 26 doi: 10.1111/ijd.15865. PMID: 34435672

Woringer-Kolopp (Pagetoid Reticulosis) disease successful response to bexarotene gel.

Ledet J, Groysman V, Sami N
Dermatol Ther 2016 Jan-Feb;29(1):28-31. Epub 2015 Sep 2 doi: 10.1111/dth.12281. PMID: 26332008

Localized pagetoid reticulosis (Woringer-Kolopp disease).

Scarabello A, Fantini F, Giannetti A, Cerroni L
Br J Dermatol 2002 Oct;147(4):806. doi: 10.1046/j.1365-2133.2002.04788.x. PMID: 12366436

Solitary skin lesions with histopathologic features of early mycosis fungoides.

Cerroni L, Fink-Puches R, El-Shabrawi-Caelen L, Soyer HP, LeBoit PE, Kerl H
Am J Dermatopathol 1999 Dec;21(6):518-24. doi: 10.1097/00000372-199912000-00003. PMID: 10608243

See all (19)

Diagnosis

Woringer-Kolopp disease mimicking psoriasis.

Wang SC, Mistry N
CMAJ 2015 Nov 17;187(17):1310. Epub 2015 Aug 24 doi: 10.1503/cmaj.141318. PMID: 26303240 Free PMC Article

A review of the solitary cutaneous T-cell lymphomas.

Ally MS, Robson A
J Cutan Pathol 2014 Sep;41(9):703-14. Epub 2014 Apr 26 doi: 10.1111/cup.12353. PMID: 24666254

Case for diagnosis.

Pedrosa AF, Ferreira O, Barros AM, Nogueira A, Bettencourt H, Azevedo F
An Bras Dermatol 2013 Sep-Oct;88(5):824-5. doi: 10.1590/abd1806-4841.20132258. PMID: 24173195 Free PMC Article

What is Woringer-Kolopp disease?

Lee AD, Cohen PR
Skinmed 2013 Jan-Feb;11(1):17-20. PMID: 23540072

Pagetoid reticulosis.

Smith NP
Clin Exp Dermatol 1982 May;7(3):i-iv. doi: 10.1111/j.1365-2230.1982.tb02421.x. PMID: 6286184

See all (40)

Therapy

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.

Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962

Pagetoid reticulosis in a 13-year old female. A unique immunohistochemical profile.

Torre-Castro J, Carrasco Santos L, Rodríguez-Pinilla SM, Requena L
J Cutan Pathol 2020 May;47(5):466-469. Epub 2019 Dec 12 doi: 10.1111/cup.13622. PMID: 31785005

Woringer-Kolopp disease mimicking psoriasis.

Wang SC, Mistry N
CMAJ 2015 Nov 17;187(17):1310. Epub 2015 Aug 24 doi: 10.1503/cmaj.141318. PMID: 26303240 Free PMC Article

Woringer-Kolopp disease mimicking foot dermatitis.

Yao Y, Mark LA
Cutis 2012 Dec;90(6):307-9, 316. PMID: 23409481

Canine cutaneous epitheliotropic T-cell lymphoma: a review.

Fontaine J, Bovens C, Bettenay S, Mueller RS
Vet Comp Oncol 2009 Mar;7(1):1-14. doi: 10.1111/j.1476-5829.2008.00176.x. PMID: 19222826

See all (10)

Prognosis

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.

Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962

Pseudocarcinomatous Hyperplasia, Squamous Cell Carcinoma, and Keratoacanthoma Associated to Lymphomas of the Skin and External Mucous Membranes: A Case Report and Literature Review.

Jeunon T, Assoni A, Verdolin A
Am J Dermatopathol 2020 Sep;42(9):662-672. doi: 10.1097/DAD.0000000000001587. PMID: 31833842

A review of the solitary cutaneous T-cell lymphomas.

Ally MS, Robson A
J Cutan Pathol 2014 Sep;41(9):703-14. Epub 2014 Apr 26 doi: 10.1111/cup.12353. PMID: 24666254

Solitary skin lesions with histopathologic features of early mycosis fungoides.

Cerroni L, Fink-Puches R, El-Shabrawi-Caelen L, Soyer HP, LeBoit PE, Kerl H
Am J Dermatopathol 1999 Dec;21(6):518-24. doi: 10.1097/00000372-199912000-00003. PMID: 10608243

Localized and disseminated pagetoid reticulosis. Diagnostic immunophenotypical findings.

Mielke V, Wolff HH, Winzer M, Sterry W
Arch Dermatol 1989 Mar;125(3):402-6. PMID: 2784302

See all (31)

Clinical prediction guides

Pediatric Mycosis Fungoides: Retrospective Analysis of a Series With CD8 + Profile and Female Predominance.

Purnak S, Mark LA
J Pediatr Hematol Oncol 2022 Oct 1;44(7):e994-e998. Epub 2021 Oct 26 doi: 10.1097/MPH.0000000000002354. PMID: 34699461

Characteristics and outcomes of 727 patients with mycosis fungoides and Sézary syndrome from a Brazilian cohort.

Miyashiro D, Sanches JA
Int J Dermatol 2022 Apr;61(4):442-454. Epub 2021 Aug 26 doi: 10.1111/ijd.15865. PMID: 34435672

Pseudocarcinomatous Hyperplasia, Squamous Cell Carcinoma, and Keratoacanthoma Associated to Lymphomas of the Skin and External Mucous Membranes: A Case Report and Literature Review.

Jeunon T, Assoni A, Verdolin A
Am J Dermatopathol 2020 Sep;42(9):662-672. doi: 10.1097/DAD.0000000000001587. PMID: 31833842

Solitary skin lesions with histopathologic features of early mycosis fungoides.

Cerroni L, Fink-Puches R, El-Shabrawi-Caelen L, Soyer HP, LeBoit PE, Kerl H
Am J Dermatopathol 1999 Dec;21(6):518-24. doi: 10.1097/00000372-199912000-00003. PMID: 10608243

Pagetoid reticulosis (Woringer-Kolopp disease): histiocyte marker (lysozyme) study and ultrastructural observations.

Natarajan S, Wilson PD
Dermatologica 1985;171(5):332-7. doi: 10.1159/000249447. PMID: 3908174

See all (20)