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Solid Lung Adenocarcinoma

MedGen UID:
234799
•Concept ID:
C1336026
•
Neoplastic Process
Synonyms: Lung Solid Adenocarcinoma with Mucin; Pulmonary Solid Adenocarcinoma with Mucin; Solid Adenocarcinoma of Lung with Mucin; Solid Adenocarcinoma of the Lung with Mucin

Definition

A morphologic variant of lung adenocarcinoma characterized by the presence of polygonal malignant cells forming sheets. Acinar, papillary, micropapillary, or lepidic growth patterns are absent. If the tumor is 100 percent solid, intracellular mucin should be present in at least five tumor cells in each of two high-power fields and confirmed with mucin immunohistochemical stains. Tumors formerly classified as large cell carcinomas expressing pneumocyte immunohistochemical markers, even if intracellular mucin is absent, are now included in this category. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSolid Lung Adenocarcinoma

Professional guidelines

PubMed

Clinical Significance of the Proposed Pathologic Criteria for Invasion by the International Association for the Study of Lung Cancer in Resected Nonmucinous Lung Adenocarcinoma.
Hong TH, Hwang S, Cho J, Choi YL, Han J, Lee G, Jeon YJ, Lee J, Park SY, Cho JH, Choi YS, Kim J, Shim YM, Kim HK
J Thorac Oncol 2024 Mar;19(3):425-433. Epub 2023 Nov 2 doi: 10.1016/j.jtho.2023.10.013. PMID: 37924973

Recent clinical studies

Etiology

Oncological characteristics of epidermal growth factor receptor-mutated clinical stage IA lung adenocarcinoma with radiologically pure-solid appearance.
Hattori A, Matsunaga T, Fukui M, Tomita H, Takamochi K, Suzuki K
J Thorac Cardiovasc Surg 2024 Sep;168(3):685-696.e2. Epub 2023 Nov 22 doi: 10.1016/j.jtcvs.2023.11.025. PMID: 37995863
Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.
Liu M, Mu J, Song F, Liu X, Jing W, Lv F
Cancer Imaging 2023 Dec 1;23(1):115. doi: 10.1186/s40644-023-00631-1. PMID: 38041175Free PMC Article
Prognostic role of preoperative carcinoembryonic antigen level in part-solid lung adenocarcinoma.
Yamanashi K, Hamaji M, Murakami K, Shimada Y, Kayawake H, Yutaka Y, Kawaguchi Y, Kudo Y, Ikeda N, Date H
Asian Cardiovasc Thorac Ann 2022 May;30(4):457-467. Epub 2022 Jan 18 doi: 10.1177/02184923211072486. PMID: 35040362
Absence of clinical benefit of FDG PET-CT in staging T1 part-solid lung adenocarcinoma.
Pencharz D, Modi S, Bandyopadhyay S, Alhun U, Marchbank N, Patel A, Wagner T
Clin Radiol 2022 Mar;77(3):195-202. Epub 2021 Dec 23 doi: 10.1016/j.crad.2021.11.013. PMID: 34953570
Significance of Lymphadenectomy in Part-Solid Lung Adenocarcinoma: Propensity Score Matched Analysis.
Hattori A, Matsunaga T, Takamochi K, Oh S, Suzuki K
Ann Thorac Surg 2018 Oct;106(4):989-997. Epub 2018 May 28 doi: 10.1016/j.athoracsur.2018.04.069. PMID: 29852148

Diagnosis

SPARC Is a Novel Positive Immunohistochemical Marker of Epithelioid Mesothelioma to Differentiate It From Lung Adenocarcinoma and/or Squamous Cell Carcinoma.
Nakagiri T, Amatya VJ, Kushitani K, Kambara T, Aoe K, Endo I, Miyata Y, Okada M, Takeshima Y
Am J Surg Pathol 2024 Feb 1;48(2):140-149. Epub 2023 Oct 30 doi: 10.1097/PAS.0000000000002147. PMID: 37899530
Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.
Liu M, Mu J, Song F, Liu X, Jing W, Lv F
Cancer Imaging 2023 Dec 1;23(1):115. doi: 10.1186/s40644-023-00631-1. PMID: 38041175Free PMC Article
Absence of clinical benefit of FDG PET-CT in staging T1 part-solid lung adenocarcinoma.
Pencharz D, Modi S, Bandyopadhyay S, Alhun U, Marchbank N, Patel A, Wagner T
Clin Radiol 2022 Mar;77(3):195-202. Epub 2021 Dec 23 doi: 10.1016/j.crad.2021.11.013. PMID: 34953570
Predictive Factors for Lymph Node Metastasis in Clinical Stage I Part-Solid Lung Adenocarcinoma.
Lee SY, Jeon JH, Jung W, Chae M, Hwang WJ, Hwang Y, Cho S, Chung JH, Kim K, Jheon S
Ann Thorac Surg 2021 Feb;111(2):456-462. Epub 2020 Jul 9 doi: 10.1016/j.athoracsur.2020.05.083. PMID: 32652067
Significance of Lymphadenectomy in Part-Solid Lung Adenocarcinoma: Propensity Score Matched Analysis.
Hattori A, Matsunaga T, Takamochi K, Oh S, Suzuki K
Ann Thorac Surg 2018 Oct;106(4):989-997. Epub 2018 May 28 doi: 10.1016/j.athoracsur.2018.04.069. PMID: 29852148

Therapy

Predicting High-Grade Patterns in Stage I Solid Lung Adenocarcinoma: A Study of 371 Patients Using Refined Radiomics and Deep Learning-Guided CatBoost Classifier.
Zheng H, Chen W, Liu J, Jian L, Luo T, Yu X
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338241308610. doi: 10.1177/15330338241308610. PMID: 39692551Free PMC Article
CT-Based Super-Resolution Deep Learning Models with Attention Mechanisms for Predicting Spread Through Air Spaces of Solid or Part-Solid Lung Adenocarcinoma.
Wang S, Liu X, Jiang C, Kang W, Pan Y, Tang X, Luo Y, Gong J
Acad Radiol 2024 Jun;31(6):2601-2609. Epub 2024 Jan 5 doi: 10.1016/j.acra.2023.12.034. PMID: 38184418

Prognosis

Oncological characteristics of epidermal growth factor receptor-mutated clinical stage IA lung adenocarcinoma with radiologically pure-solid appearance.
Hattori A, Matsunaga T, Fukui M, Tomita H, Takamochi K, Suzuki K
J Thorac Cardiovasc Surg 2024 Sep;168(3):685-696.e2. Epub 2023 Nov 22 doi: 10.1016/j.jtcvs.2023.11.025. PMID: 37995863
Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.
Liu M, Mu J, Song F, Liu X, Jing W, Lv F
Cancer Imaging 2023 Dec 1;23(1):115. doi: 10.1186/s40644-023-00631-1. PMID: 38041175Free PMC Article
Prognostic role of preoperative carcinoembryonic antigen level in part-solid lung adenocarcinoma.
Yamanashi K, Hamaji M, Murakami K, Shimada Y, Kayawake H, Yutaka Y, Kawaguchi Y, Kudo Y, Ikeda N, Date H
Asian Cardiovasc Thorac Ann 2022 May;30(4):457-467. Epub 2022 Jan 18 doi: 10.1177/02184923211072486. PMID: 35040362
Prognosis of epidermal growth factor receptor-mutated stage I lung adenocarcinoma with radiologically solid features.
Hattori A, Matsunaga T, Fukui M, Takamochi K, Suzuki K
Eur J Cardiothorac Surg 2022 Mar 24;61(4):769-777. doi: 10.1093/ejcts/ezab481. PMID: 34791156
Significance of Lymphadenectomy in Part-Solid Lung Adenocarcinoma: Propensity Score Matched Analysis.
Hattori A, Matsunaga T, Takamochi K, Oh S, Suzuki K
Ann Thorac Surg 2018 Oct;106(4):989-997. Epub 2018 May 28 doi: 10.1016/j.athoracsur.2018.04.069. PMID: 29852148

Clinical prediction guides

Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.
Liu M, Mu J, Song F, Liu X, Jing W, Lv F
Cancer Imaging 2023 Dec 1;23(1):115. doi: 10.1186/s40644-023-00631-1. PMID: 38041175Free PMC Article
Prognostic role of preoperative carcinoembryonic antigen level in part-solid lung adenocarcinoma.
Yamanashi K, Hamaji M, Murakami K, Shimada Y, Kayawake H, Yutaka Y, Kawaguchi Y, Kudo Y, Ikeda N, Date H
Asian Cardiovasc Thorac Ann 2022 May;30(4):457-467. Epub 2022 Jan 18 doi: 10.1177/02184923211072486. PMID: 35040362
Prognosis of epidermal growth factor receptor-mutated stage I lung adenocarcinoma with radiologically solid features.
Hattori A, Matsunaga T, Fukui M, Takamochi K, Suzuki K
Eur J Cardiothorac Surg 2022 Mar 24;61(4):769-777. doi: 10.1093/ejcts/ezab481. PMID: 34791156
Lung Adenocarcinomas Manifesting as Radiological Part-Solid Nodules Define a Special Clinical Subtype.
Ye T, Deng L, Wang S, Xiang J, Zhang Y, Hu H, Sun Y, Li Y, Shen L, Xie L, Gu W, Zhao Y, Fu F, Peng W, Chen H
J Thorac Oncol 2019 Apr;14(4):617-627. Epub 2019 Jan 17 doi: 10.1016/j.jtho.2018.12.030. PMID: 30659988
Significance of Lymphadenectomy in Part-Solid Lung Adenocarcinoma: Propensity Score Matched Analysis.
Hattori A, Matsunaga T, Takamochi K, Oh S, Suzuki K
Ann Thorac Surg 2018 Oct;106(4):989-997. Epub 2018 May 28 doi: 10.1016/j.athoracsur.2018.04.069. PMID: 29852148

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