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Cellular Angiofibroma

MedGen UID:
235072
•Concept ID:
C1367534
•
Neoplastic Process
Synonym: Cellular angiofibroma
SNOMED CT: Cellular angiofibroma (1293012008); Cellular angiofibroma (1293014009)

Definition

A benign mesenchymal neoplasm that usually arises in the superficial soft tissues of the vulva or inguinal and scrotal regions. It is characterized by the presence of a cellular fibroblastic proliferation in an edematous to fibrous stroma containing numerous vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Angiofibroma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Contemporary management of juvenile angiofibroma.
Bertazzoni G, Schreiber A, Ferrari M, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2019 Feb;27(1):47-53. doi: 10.1097/MOO.0000000000000505. PMID: 30507688
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183

Recent clinical studies

Etiology

Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Cellular Angiofibroma Presenting as an Inguinal Subcutaneous Mass: a Case Report and Review of the Literature.
Schiebel F, Cassim R
W V Med J 2016 Nov-Dec;112(6):40-3. PMID: 29368830
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211
Mesenchymal tumors and tumor-like lesions of the female genital tract: a selective review with emphasis on recently described entities.
Nielsen GP, Young RH
Int J Gynecol Pathol 2001 Apr;20(2):105-27. doi: 10.1097/00004347-200104000-00002. PMID: 11293156

Diagnosis

Massive cellular angiofibroma of the vulva.
Mishina A, Petrovici V, Mishin I
Arch Gynecol Obstet 2024 Apr;309(4):1665-1667. Epub 2023 Oct 11 doi: 10.1007/s00404-023-07245-9. PMID: 37819477
Mesenchymal lesions of the vulva.
Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293
Cervicovaginal cellular angiofibroma.
Van Mulders S, Faes E, Broeckx G, Jacquemyn Y
BMJ Case Rep 2020 Jul 16;13(7) doi: 10.1136/bcr-2020-235241. PMID: 32675122Free PMC Article
Cellular angiofibroma in women: a review of the literature.
Mandato VD, Santagni S, Cavazza A, Aguzzoli L, Abrate M, La Sala GB
Diagn Pathol 2015 Jul 19;10:114. doi: 10.1186/s13000-015-0361-6. PMID: 26187500Free PMC Article
Genital soft tissue tumors.
Schoolmeester JK, Fritchie KJ
J Cutan Pathol 2015 Jul;42(7):441-51. Epub 2015 May 21 doi: 10.1111/cup.12507. PMID: 25925211

Therapy

Radioguided surgery of mesenchymal tumors with (125)I seeds.
Barranquero AG, Corral Moreno S, Martínez Lorca A, Hernández-Cosido L, Rioja Martín ME, Mena Mateo A, Cabañas Montero J, Fernández-Cebrián JM
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Sep-Oct;42(5):296-301. Epub 2023 Apr 14 doi: 10.1016/j.remnie.2023.04.004. PMID: 37062451
Combination of high-frequency electric with 5-ALA photodynamic therapy in cellular angiofibroma of vulva: A case report.
Yu YT, Nong X, Neng YJ, Wu WJ, Li Y, Zhang M
Photodiagnosis Photodyn Ther 2023 Jun;42:103289. Epub 2023 Feb 3 doi: 10.1016/j.pdpdt.2023.103289. PMID: 36738906
Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report.
Arakaki K, Chinen K, Kamiya M, Tanabe Y, Tawata N, Ikehara F, Uehara K, Shimabukuro H, Kinjo T
Int J Clin Exp Pathol 2014;7(12):8972-9. Epub 2014 Dec 1 PMID: 25674275Free PMC Article
Angiomyofibroblastoma-like tumor (cellular angiofibroma) in the male inguinal region.
Miyajima K, Hasegawa S, Oda Y, Toyoshima S, Tsuneyoshi M, Motooka M, Matsuura Y, Ishioka H, Ono M
Radiat Med 2007 May;25(4):173-7. Epub 2007 May 28 doi: 10.1007/s11604-006-0114-2. PMID: 17514368
Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient.
Sabah M, Mohan P, Kay E
Virchows Arch 2006 Oct;449(4):489-92. Epub 2006 Sep 7 doi: 10.1007/s00428-006-0289-z. PMID: 16957933

Prognosis

Cellular angiofibroma arising in the anorectal region: clinicopathologic and immunohistochemical analysis of five cases.
Matsumoto NP, Ahmed M, Rottmann D, Laskin WB
Hum Pathol 2022 Feb;120:1-8. Epub 2021 Nov 20 doi: 10.1016/j.humpath.2021.11.006. PMID: 34808212
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Paratesticular cellular angiofibroma with atypical (bizarre) cells: case report and literature review.
Val-Bernal JF, Azueta A, Parra A, Mediavilla E, Zubillaga S
Pathol Res Pract 2013 Jun;209(6):388-92. Epub 2013 Mar 26 doi: 10.1016/j.prp.2013.03.008. PMID: 23582366
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

Clinical prediction guides

Cellular angiofibroma of the vagina: A case report and literature review.
Cai XQ, Ye XG, Zhang YZ, Shen ZL, Hong K, Zhang SZ
Medicine (Baltimore) 2022 Sep 2;101(35):e30293. doi: 10.1097/MD.0000000000030293. PMID: 36107545Free PMC Article
Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component.
McCarthy AJ, Chetty R
J Clin Pathol 2018 Jun;71(6):483-492. Epub 2018 Jan 22 doi: 10.1136/jclinpath-2017-204975. PMID: 29358476
Paratesticular cellular angiofibroma with atypical (bizarre) cells: case report and literature review.
Val-Bernal JF, Azueta A, Parra A, Mediavilla E, Zubillaga S
Pathol Res Pract 2013 Jun;209(6):388-92. Epub 2013 Mar 26 doi: 10.1016/j.prp.2013.03.008. PMID: 23582366
Recent developments in vulvovaginal pathology.
McCluggage WG
Histopathology 2009 Jan;54(2):156-73. doi: 10.1111/j.1365-2559.2008.03098.x. PMID: 18637148
Vulvovaginal soft tissue tumours: update and review.
Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

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