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Human papillomavirus-related penile squamous cell carcinoma

MedGen UID:
235178
•Concept ID:
C1334056
•
Neoplastic Process
Synonyms: HPV-Related Penile Squamous Cell Carcinoma; HPV-related penile squamous cell carcinoma; Human Papilloma Virus Related Penile Squamous Cell Carcinoma; human papilloma virus related penile squamous cell carcinoma; Human Papilloma Virus-Related Penile Squamous Cell Carcinoma; human papilloma virus-related penile squamous cell carcinoma; Human Papillomavirus-Related Penile Squamous Cell Carcinoma; human papillomavirus-related penile squamous cell carcinoma; Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis; Penile HPV-Associated Squamous Cell Carcinoma; Penile Human Papillomavirus-Associated Squamous Cell Carcinoma; Penile Human Papillomavirus-Related Squamous Cell Carcinoma
 
Monarch Initiative: MONDO:0020656

Definition

A squamous cell carcinoma that arises from the penis and is caused by human papillomavirus infection. [from NCI]

Professional guidelines

PubMed

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Management of advanced primary urethral carcinomas.
Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C
BJU Int 2014 Jul;114(1):25-31. Epub 2014 May 22 doi: 10.1111/bju.12630. PMID: 24447439

Recent clinical studies

Etiology

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Profiling of expression of human papillomavirus-related cancer miRNAs in penile squamous cell carcinomas.
Barzon L, Cappellesso R, Peta E, Militello V, Sinigaglia A, Fassan M, Simonato F, Guzzardo V, Ventura L, Blandamura S, Gardiman M, Palù G, Fassina A
Am J Pathol 2014 Dec;184(12):3376-83. Epub 2014 Nov 22 doi: 10.1016/j.ajpath.2014.08.004. PMID: 25455689
Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies.
Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM
Head Neck 2014 Jun;36(6):819-25. Epub 2013 Sep 2 doi: 10.1002/hed.23379. PMID: 23720126
Incidence of potentially human papillomavirus-related neoplasms in the United States, 1978 to 2007.
Kurdgelashvili G, Dores GM, Srour SA, Chaturvedi AK, Huycke MM, Devesa SS
Cancer 2013 Jun 15;119(12):2291-9. Epub 2013 Apr 11 doi: 10.1002/cncr.27989. PMID: 23580435Free PMC Article
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720

Diagnosis

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Management of advanced primary urethral carcinomas.
Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C
BJU Int 2014 Jul;114(1):25-31. Epub 2014 May 22 doi: 10.1111/bju.12630. PMID: 24447439
Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies.
Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM
Head Neck 2014 Jun;36(6):819-25. Epub 2013 Sep 2 doi: 10.1002/hed.23379. PMID: 23720126
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Human papillomavirus-related genital disease in the immunocompromised host: Part I.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):867.e1-14; quiz 881-2. doi: 10.1016/j.jaad.2010.12.050. PMID: 22583720

Therapy

Immune-based Therapies for Penile Cancer.
Al Assaad M, Safa H, Mercinelli C, Spiess PE, Necchi A, Chahoud J
Urol Clin North Am 2024 Aug;51(3):355-365. Epub 2024 Apr 16 doi: 10.1016/j.ucl.2024.03.014. PMID: 38925738

Prognosis

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Management of advanced primary urethral carcinomas.
Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C
BJU Int 2014 Jul;114(1):25-31. Epub 2014 May 22 doi: 10.1111/bju.12630. PMID: 24447439
Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies.
Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM
Head Neck 2014 Jun;36(6):819-25. Epub 2013 Sep 2 doi: 10.1002/hed.23379. PMID: 23720126
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence.
Oertell J, Caballero C, Iglesias M, Chaux A, Amat L, Ayala E, Rodríguez I, Velázquez EF, Barreto JE, Ayala G, Cubilla AL
Histopathology 2011 May;58(6):925-33. doi: 10.1111/j.1365-2559.2011.03816.x. PMID: 21585428

Clinical prediction guides

Update on Pathologic Conditions, Imaging Findings, Prevention, and Management of Human Papillomavirus-related Neoplasms.
Katabathina VS, Ghannam S, Chen M, Desalme B, Gabos R, Emejulu I, Sandhu PK, Valente P, Dasyam AK, Prasad SR
Radiographics 2024 Aug;44(8):e230179. doi: 10.1148/rg.230179. PMID: 39024173
Profiling of expression of human papillomavirus-related cancer miRNAs in penile squamous cell carcinomas.
Barzon L, Cappellesso R, Peta E, Militello V, Sinigaglia A, Fassan M, Simonato F, Guzzardo V, Ventura L, Blandamura S, Gardiman M, Palù G, Fassina A
Am J Pathol 2014 Dec;184(12):3376-83. Epub 2014 Nov 22 doi: 10.1016/j.ajpath.2014.08.004. PMID: 25455689
Advances in the pathology of penile carcinomas.
Chaux A, Cubilla AL
Hum Pathol 2012 Jun;43(6):771-89. doi: 10.1016/j.humpath.2012.01.014. PMID: 22595011
Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases.
Chaux A, Tamboli P, Ayala A, Soares F, Rodríguez I, Barreto J, Cubilla AL
Mod Pathol 2010 Jun;23(6):896-904. Epub 2010 Mar 19 doi: 10.1038/modpathol.2010.69. PMID: 20305615
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Mar;34(3):385-92. doi: 10.1097/PAS.0b013e3181cdad23. PMID: 20139761

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