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Intraductal breast papillomatosis

MedGen UID:
235224
•Concept ID:
C1334247
•
Neoplastic Process
Synonyms: Breast Intraductal Papillomatosis; breast intraductal papillomatosis; Breast Multiple Intraductal Papillomas; intraductal breast papillomatosis; intraductal papillomatosis of breast; intraductal papillomatosis of the breast
 
Monarch Initiative: MONDO:0004253

Definition

A benign breast neoplasm characterized by the presence of multiple intraductal papillomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraductal breast papillomatosis

Professional guidelines

PubMed

Clinical practice guidelines for intraductal papilloma: Chinese Society of breast surgery (CSBrS) practice guidelines 2021.
Wu D, Shi AP, Song AL, Fan ZM; Chinese Society of Breast Surgery
Chin Med J (Engl) 2021 May 19;134(14):1658-1660. doi: 10.1097/CM9.0000000000001533. PMID: 34039866Free PMC Article
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
ASO Author Reflections: Management of Benign Breast Intraductal Papillomas Without Atypia Diagnosed at Imaging-Guided Biopsies.
He H, Whitman GJ, Moseley T
Ann Surg Oncol 2021 Mar;28(3):1356-1357. Epub 2020 Sep 8 doi: 10.1245/s10434-020-09118-w. PMID: 32901314

Recent clinical studies

Etiology

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Nipple discharge screening.
Zervoudis S, Iatrakis G, Economides P, Polyzos D, Navrozoglou I
Womens Health (Lond) 2010 Jan;6(1):135-51. doi: 10.2217/whe.09.81. PMID: 20050819

Therapy

Underestimation of breast cancer in intraductal papillomas treated with vacuum-assisted core needle biopsy.
Hodorowicz-Zaniewska D, Siarkiewicz B, Brzuszkiewicz K, Szpor J
Ginekol Pol 2019;90(3):122-127. doi: 10.5603/GP.2019.0022. PMID: 30950000
Liver abscess with Citrobacter koseri bacteremia.
Kanzawa Y, Ishimaru N, Seto H, Tsutsumi T, Kinami S
Infez Med 2018 Sep 1;26(3):266-269. PMID: 30246771
Reproducibility and validity of pathologic classifications of benign breast disease and implications for clinical applications.
Bodian CA, Perzin KH, Lattes R, Hoffmann P
Cancer 1993 Jun 15;71(12):3908-13. doi: 10.1002/1097-0142(19930615)71:12<3908::aid-cncr2820711218>3.0.co;2-f. PMID: 8508356
Minimal breast carcinoma.
Nevin JE, Pinzón G, Morán TJ, Baggerly JT
Am J Surg 1980 Mar;139(3):357-9. doi: 10.1016/0002-9610(80)90293-7. PMID: 6244748
Mammary duct injection.
Threatt B, Appelman HD
Radiology 1973 Jul;108(1):71-6. doi: 10.1148/108.1.71. PMID: 4350793

Prognosis

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.
Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.
Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809
Liver abscess with Citrobacter koseri bacteremia.
Kanzawa Y, Ishimaru N, Seto H, Tsutsumi T, Kinami S
Infez Med 2018 Sep 1;26(3):266-269. PMID: 30246771
Papillary lesions of the breast: a review.
Mulligan AM, O'Malley FP
Adv Anat Pathol 2007 Mar;14(2):108-19. doi: 10.1097/PAP.0b013e318032508d. PMID: 17471117

Clinical prediction guides

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.
Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Breast Imaging Reporting and Data System Classification for Central-Type Intra-Ductal Papillary Masses: Current Problems and Evaluation of Modified Parameters.
Zhang H, Sun Y, Zhang J, Wang S
Ultrasound Med Biol 2021 Apr;47(4):960-966. Epub 2021 Jan 15 doi: 10.1016/j.ultrasmedbio.2020.12.005. PMID: 33455809
Surgical management of high-risk breast lesions.
Degnim AC, King TA
Surg Clin North Am 2013 Apr;93(2):329-40. Epub 2013 Feb 8 doi: 10.1016/j.suc.2012.12.005. PMID: 23464689

Recent systematic reviews

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.
Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061

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