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Malignant Testicular Sertoli Cell Tumor

MedGen UID:: 235304
•Concept ID:: C1334626
•: Neoplastic Process

Synonyms:

Malignant Sertoli Cell Neoplasm of Testis; Malignant Sertoli Cell Neoplasm of the Testis; Malignant Sertoli Cell Tumor of Testis; Malignant Sertoli Cell Tumor of the Testis; Malignant Testicular Sertoli Cell Neoplasm

Definition

A Sertoli cell tumor that arises from the testis and is characterized by nuclear pleomorphism, increased mitotic activity and necrotic changes. Metastases may be present at diagnosis. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Testicular Sertoli Cell Tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Sertoli cell tumor
        Malignant Sertoli cell tumor
        Malignant Testicular Sertoli Cell Tumor

Professional guidelines

PubMed

Practices recommendations in the applications of immunohistochemistry and molecular genetics in testicular tumors. Review article.

Michalová K, Michal M, Hora M, Hes O, Michal M
Cesk Patol 2020 Summer;56(3):153-160. PMID: 33076667

Genetic engineering to study testicular tumorigenesis.

Yan W, Burns KH, Matzuk MM
APMIS 2003 Jan;111(1):174-81; discussion 182-3. doi: 10.1034/j.1600-0463.2003.1110121.x. PMID: 12760377

Treatment of testicular tumors.

Hendrick JW, Bohne AW
South Med J 1971 Jul;64(7):873-81. doi: 10.1097/00007611-197107000-00021. PMID: 4397418

See all (14)

Recent clinical studies

Etiology

Testicular Lesions in Infertile Men.

Dupeux M, Maxwell F, Rocher L, Izard V, Guettier C, Ferlicot S
Am J Clin Pathol 2022 Jun 7;157(6):936-941. doi: 10.1093/ajcp/aqab214. PMID: 34935941

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

Androgen-Secreting Ovarian Tumors.

Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557 Free PMC Article

Testicular tumors other than germ cell tumors.

Young RH, Talerman A
Semin Diagn Pathol 1987 Nov;4(4):342-60. PMID: 2832918

See all (125)

Diagnosis

Large-Cell Calcifying Sertoli Cell Tumor.

Gupta S, Erickson LA
Mayo Clin Proc 2024 Aug;99(8):1347-1348. doi: 10.1016/j.mayocp.2024.05.031. PMID: 39097341

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Testicular tumours.

Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Testicular tumors.

Markland C
Curr Probl Surg 1968 Sep:3-51. doi: 10.1016/s0011-3840(68)80001-2. PMID: 4386486

See all (247)

Therapy

INSL3 Expression in Leydig Cell Hyperplasia and Leydig Cell Tumors.

Lakis NS, Lombardo KA, Mangray S, Netto GJ, Salles D, Matoso A
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):203-209. doi: 10.1097/PAI.0000000000000567. PMID: 29084059

Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.

Gourgari E, Saloustros E, Stratakis CA
Curr Opin Pediatr 2012 Aug;24(4):518-22. doi: 10.1097/MOP.0b013e328355a279. PMID: 22732638 Free PMC Article

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Malignant androblastoma (Sertoli cell tumor) of the testis. A case report with a review of the literature.

Morin LJ, Loening S
J Urol 1975 Sep;114(3):476-80. doi: 10.1016/s0022-5347(17)67062-9. PMID: 167202

Testicular tumours.

Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

See all (36)

Prognosis

Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries.

Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, Devins KM, Young RH, Olson DR, Mallinger PHR, Mitchell SG, Hoffman LM, Halliday G, Suleymanova AM, Glade Bender JL, Messinger YH, Herzog CE, Field AL, Frazier AL, Stewart DR, Dehner LP, Hill DA, Billmire DF, Schneider DT, Schultz KAP
Gynecol Oncol 2024 Jul;186:117-125. Epub 2024 Apr 23 doi: 10.1016/j.ygyno.2024.04.005. PMID: 38657450 Free PMC Article

Characteristic ultrasound appearance of a rare testis tumor: Bilateral multiple large-cell calcifying Sertoli cell tumor.

Ayaz E, Okur N, Çelebi C, Özekinci SÖ
J Clin Ultrasound 2023 Oct;51(8):1419-1421. Epub 2023 Aug 16 doi: 10.1002/jcu.23535. PMID: 37584318

An introduction to the WHO 5th edition 2022 classification of testicular tumours.

Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823 Free PMC Article

Ovarian Sex Cord-Stromal Tumors.

Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560 Free PMC Article

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

See all (109)

Clinical prediction guides

Large cell calcifying Sertoli cell tumour: a contemporary multi-institutional case series highlighting the diagnostic utility of PRKAR1A immunohistochemistry.

Anderson WJ, Gordetsky JB, Idrees MT, Al-Obaidy KI, Kao CS, Cornejo KM, Wobker SE, Cheville JC, Vargas SO, Fletcher CDM, Hirsch MS, Acosta AM
Histopathology 2022 Mar;80(4):677-685. Epub 2022 Jan 5 doi: 10.1111/his.14599. PMID: 34780072

Comparative immunomorphology of testicular Sertoli and sertoliform tumors.

Mesa H, Gilles S, Datta MW, Murugan P, Larson W, Dachel S, Manivel JC
Hum Pathol 2017 Mar;61:181-189. Epub 2016 Dec 8 doi: 10.1016/j.humpath.2016.11.004. PMID: 27939779

Ovarian Sex Cord-Stromal Tumors.

Difficult differential diagnoses in testicular pathology.

Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906

Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights.

Looijenga LH
J Pathol 2009 Jun;218(2):146-62. doi: 10.1002/path.2522. PMID: 19253916

See all (97)

Recent systematic reviews

Sertoli Cell Tumors of the Testes: Systematic Literature Review and Meta-Analysis of Outcomes in 435 Patients.

Grogg J, Schneider K, Bode PK, Kranzbühler B, Eberli D, Sulser T, Lorch A, Beyer J, Hermanns T, Fankhauser CD
Oncologist 2020 Jul;25(7):585-590. Epub 2020 Feb 11 doi: 10.1634/theoncologist.2019-0692. PMID: 32043680 Free PMC Article

See all (1)

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