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Methotrexate-Associated Diffuse Large B-Cell Lymphoma

MedGen UID:
235324
•Concept ID:
C1334746
•
Neoplastic Process

Definition

A diffuse large B-cell lymphoma that develops in patients who are immunosuppressed with methotrexate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMethotrexate-Associated Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Spontaneous remission of "methotrexate-associated lymphoproliferative disorders" after discontinuation of immunosuppressive treatment for autoimmune disease. Review of the literature.
Rizzi R, Curci P, Delia M, Rinaldi E, Chiefa A, Specchia G, Liso V
Med Oncol 2009;26(1):1-9. Epub 2008 May 7 doi: 10.1007/s12032-008-9069-8. PMID: 18461290

Recent clinical studies

Etiology

Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Satou A, Tabata T, Suzuki Y, Sato Y, Tahara I, Mochizuki K, Oishi N, Takahara T, Yoshino T, Tsuzuki T, Nakamura S
Virchows Arch 2021 May;478(5):969-976. Epub 2020 Nov 9 doi: 10.1007/s00428-020-02967-6. PMID: 33169195
Methotrexate-associated Lymphoproliferative Disorders in Patients With Rheumatoid Arthritis: Clinicopathologic Features and Prognostic Factors.
Kurita D, Miyoshi H, Ichikawa A, Kato K, Imaizumi Y, Seki R, Sato K, Sasaki Y, Kawamoto K, Shimono J, Yamada K, Muto R, Kizaki M, Nagafuji K, Tamaru JI, Tokuhira M, Ohshima K
Am J Surg Pathol 2019 Jul;43(7):869-884. doi: 10.1097/PAS.0000000000001271. PMID: 31116708
Cutaneous manifestations of methotrexate-associated lymphoproliferative disorders: report of two cases and a review of the literature.
Shimizu S, Inokuma D, Murata J, Kikuchi K, Ito T, Fukasawa Y, Mukai M, Moriuchi R
Acta Derm Venereol 2015 Mar;95(3):366-7. doi: 10.2340/00015555-1951. PMID: 25138609
Methotrexate-associated B-cell lymphoproliferative disorders presenting in the skin: A clinicopathologic and immunophenotypical study of 10 cases.
Koens L, Senff NJ, Vermeer MH, Willemze R, Jansen PM
Am J Surg Pathol 2014 Jul;38(7):999-1006. doi: 10.1097/PAS.0000000000000225. PMID: 24805861

Diagnosis

Diffuse Large B-cell Lymphoma with Adrenal Involvement Presenting as Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorders: Sustained Remission with Methotrexate Termination Alone in Two Cases.
Yasuda H, Ando J, Yoshida S, Ota Y, Komatsu N, Ando M
Intern Med 2023 Feb 15;62(4):601-604. Epub 2022 Jul 5 doi: 10.2169/internalmedicine.0130-22. PMID: 35793959Free PMC Article
PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Satou A, Tabata T, Suzuki Y, Sato Y, Tahara I, Mochizuki K, Oishi N, Takahara T, Yoshino T, Tsuzuki T, Nakamura S
Virchows Arch 2021 May;478(5):969-976. Epub 2020 Nov 9 doi: 10.1007/s00428-020-02967-6. PMID: 33169195
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients.
Carreras J, Yukie Kikuti Y, Miyaoka M, Hiraiwa S, Tomita S, Ikoma H, Kondo Y, Shiraiwa S, Ando K, Sato S, Suzuki Y, Miura I, Roncador G, Nakamura N
Am J Surg Pathol 2018 Jul;42(7):936-950. doi: 10.1097/PAS.0000000000001071. PMID: 29738359
Cutaneous manifestations of methotrexate-associated lymphoproliferative disorders: report of two cases and a review of the literature.
Shimizu S, Inokuma D, Murata J, Kikuchi K, Ito T, Fukasawa Y, Mukai M, Moriuchi R
Acta Derm Venereol 2015 Mar;95(3):366-7. doi: 10.2340/00015555-1951. PMID: 25138609

Therapy

Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Methotrexate-Associated Lymphoproliferative Disorder of the Stomach Observed by Magnifying Narrow-Band Imaging Endoscopy.
Kawasaki K, Eizuka M, Nakamura S, Sugai T, Matsumoto T
J Gastrointestin Liver Dis 2019 Jun 1;28:145. doi: 10.15403/jgld-170. PMID: 31204399
Clinicopathological analysis of methotrexate-associated lymphoproliferative disorders: Comparison of diffuse large B-cell lymphoma and classical Hodgkin lymphoma types.
Gion Y, Iwaki N, Takata K, Takeuchi M, Nishida K, Orita Y, Tachibana T, Yoshino T, Sato Y
Cancer Sci 2017 Jun;108(6):1271-1280. Epub 2017 May 23 doi: 10.1111/cas.13249. PMID: 28380678Free PMC Article
Cutaneous manifestations of methotrexate-associated lymphoproliferative disorders: report of two cases and a review of the literature.
Shimizu S, Inokuma D, Murata J, Kikuchi K, Ito T, Fukasawa Y, Mukai M, Moriuchi R
Acta Derm Venereol 2015 Mar;95(3):366-7. doi: 10.2340/00015555-1951. PMID: 25138609
EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate.
Hsiao SC, Ichinohasama R, Lin SH, Liao YL, Chang ST, Cho CY, Chuang SS
Pathol Res Pract 2009;205(1):43-9. Epub 2008 Oct 31 doi: 10.1016/j.prp.2008.08.006. PMID: 18951733

Prognosis

PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Programmed cell death-ligand 1 (PD-L1)(+) tumour cells and low-reacting programmed cell death 1 (PD1)(+) tumour-infiltrating lymphocytes predict poor prognosis in Epstein-Barr virus(+) diffuse large B-cell lymphoma.
Kimura S, Oshiro Y, Iwasaki H, Kadowaki M, Mihashi Y, Sakata T, Kawauchi S, Wang Z, Takamatsu Y, Takeshita M
Clin Exp Med 2022 Aug;22(3):411-419. Epub 2021 Sep 13 doi: 10.1007/s10238-021-00754-4. PMID: 34515880
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Cutaneous manifestations of methotrexate-associated lymphoproliferative disorders: report of two cases and a review of the literature.
Shimizu S, Inokuma D, Murata J, Kikuchi K, Ito T, Fukasawa Y, Mukai M, Moriuchi R
Acta Derm Venereol 2015 Mar;95(3):366-7. doi: 10.2340/00015555-1951. PMID: 25138609
EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate.
Hsiao SC, Ichinohasama R, Lin SH, Liao YL, Chang ST, Cho CY, Chuang SS
Pathol Res Pract 2009;205(1):43-9. Epub 2008 Oct 31 doi: 10.1016/j.prp.2008.08.006. PMID: 18951733

Clinical prediction guides

PD-L1 expression is associated with the spontaneous regression of patients with methotrexate-associated lymphoproliferative disorders.
Gion Y, Doi M, Nishimura Y, Ikeda T, Filiz Nishimura M, Sakamoto M, Egusa Y, Nishikori A, Fujita A, Iwaki N, Nakamura N, Yoshino T, Sato Y
Cancer Med 2022 Jan;11(2):417-432. Epub 2021 Nov 29 doi: 10.1002/cam4.4462. PMID: 34842351Free PMC Article
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Nodal EBV-positive polymorphic B cell lymphoproliferative disorder with plasma cell differentiation: clinicopathological analysis of five cases.
Satou A, Tabata T, Suzuki Y, Sato Y, Tahara I, Mochizuki K, Oishi N, Takahara T, Yoshino T, Tsuzuki T, Nakamura S
Virchows Arch 2021 May;478(5):969-976. Epub 2020 Nov 9 doi: 10.1007/s00428-020-02967-6. PMID: 33169195
Methotrexate-Associated Lymphoproliferative Disorder of the Stomach Observed by Magnifying Narrow-Band Imaging Endoscopy.
Kawasaki K, Eizuka M, Nakamura S, Sugai T, Matsumoto T
J Gastrointestin Liver Dis 2019 Jun 1;28:145. doi: 10.15403/jgld-170. PMID: 31204399
Cutaneous manifestations of methotrexate-associated lymphoproliferative disorders: report of two cases and a review of the literature.
Shimizu S, Inokuma D, Murata J, Kikuchi K, Ito T, Fukasawa Y, Mukai M, Moriuchi R
Acta Derm Venereol 2015 Mar;95(3):366-7. doi: 10.2340/00015555-1951. PMID: 25138609

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