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Breast extraskeletal osteosarcoma

MedGen UID:
235414
•Concept ID:
C1335149
•
Neoplastic Process
Synonyms: Breast Extraskeletal Osteosarcoma; breast extraskeletal osteosarcoma; Breast Osteosarcoma; breast osteosarcoma; breast osteosarcoma (disease); Osteogenic Breast Sarcoma; osteogenic breast sarcoma; Osteogenic Sarcoma of Breast; osteogenic sarcoma of breast; Osteogenic Sarcoma of the Breast; osteogenic sarcoma of the breast; Osteosarcoma of Breast; osteosarcoma of breast; Osteosarcoma of the Breast; osteosarcoma of the breast
 
Monarch Initiative: MONDO:0004360

Definition

An osteosarcoma arising from the breast tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast extraskeletal osteosarcoma

Recent clinical studies

Etiology

Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system.
Sparreboom BD, Trautman J, Yaxley J
J Med Imaging Radiat Oncol 2022 Sep;66(6):812-818. Epub 2022 Jul 16 doi: 10.1111/1754-9485.13456. PMID: 35842789
Increased Prevalence of Malignancies in Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS): Data from a National Referral Center and the Dutch National Pathology Registry (PALGA).
Hagelstein-Rotman M, Meier ME, Majoor BCJ, Cleven AHG, Dijkstra PDS, Hamdy NAT, van de Sande MAJ, Dekkers OM, Appelman-Dijkstra NM
Calcif Tissue Int 2021 Mar;108(3):346-353. Epub 2020 Nov 23 doi: 10.1007/s00223-020-00780-6. PMID: 33226445
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity.
Makise N, Sekimizu M, Kubo T, Wakai S, Watanabe SI, Kato T, Kinoshita T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A
Histopathology 2018 Jul;73(1):147-156. Epub 2018 Apr 19 doi: 10.1111/his.13506. PMID: 29489027
Extraosseous osteosarcoma: single institutional experience in Korea.
Lee S, Lee MR, Lee SJ, Ahn HK, Yi J, Yi SY, Seo SW, Sung KS, Park JO, Lee J
Asia Pac J Clin Oncol 2010 Jun;6(2):126-9. doi: 10.1111/j.1743-7563.2010.01278.x. PMID: 20565425
Primary osteogenic sarcoma of the breast: a clinicopathologic analysis of 50 cases.
Silver SA, Tavassoli FA
Am J Surg Pathol 1998 Aug;22(8):925-33. doi: 10.1097/00000478-199808000-00002. PMID: 9706972

Diagnosis

Expression of TRPS1 in phyllodes tumor and sarcoma of the breast.
Wang J, Wang WL, Sun H, Huo L, Wu Y, Chen H, Gan Q, Meis JM, Maloney N, Lazar AJ, Yoon EC, Albarracin CT, Krishnamurthy S, Middleton LP, Resetkova E, Yu W, Tan D, Lu W, Solis Soto LM, Wang S, Wistuba II, Parwani AV, Prieto VG, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Mar;121:73-80. Epub 2022 Jan 19 doi: 10.1016/j.humpath.2022.01.002. PMID: 35063444
Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review.
Mujtaba B, Nassar SM, Aslam R, Garg N, Madewell JE, Taher A, Hanafy AK, Whitman G
Curr Probl Diagn Radiol 2020 Mar-Apr;49(2):116-123. Epub 2019 Jan 3 doi: 10.1067/j.cpradiol.2019.01.001. PMID: 30655112
Extraskeletal Ewing's sarcoma arising in the larynx.
Lynch MC, Baker A, Drabick JJ, Williams N, Goldenberg D
Head Neck Pathol 2014 Jun;8(2):225-8. Epub 2013 Sep 27 doi: 10.1007/s12105-013-0492-6. PMID: 24072589Free PMC Article
Primary osteosarcoma of the breast.
Murakami S, Isozaki H, Shou T, Sakai K, Yamamoto Y, Oomori M, Toyoda H
Pathol Int 2009 Feb;59(2):111-5. doi: 10.1111/j.1440-1827.2008.02338.x. PMID: 19154266
Extraskeletal osteosarcoma with a highly malignant course. A case report.
Simank HG, Welkerling H, Bernd L, Ewerbeck V
Int Orthop 1995;19(4):251-4. doi: 10.1007/BF00185234. PMID: 8557425

Therapy

Extraskeletal Ewing's sarcoma arising in the larynx.
Lynch MC, Baker A, Drabick JJ, Williams N, Goldenberg D
Head Neck Pathol 2014 Jun;8(2):225-8. Epub 2013 Sep 27 doi: 10.1007/s12105-013-0492-6. PMID: 24072589Free PMC Article
Osteosarcoma of breast: a rare case of extraskeletal osteosarcoma.
Kallianpur AA, Gupta R, Muduly DK, Kapali A, Subbarao KC
J Cancer Res Ther 2013 Apr-Jun;9(2):292-4. doi: 10.4103/0973-1482.113392. PMID: 23771379
Postradiation soft tissue sarcoma: a multiinstitutional analysis of 14 cases in Japan.
Fang Z, Matsumoto S, Ae K, Kawaguchi N, Yoshikawa H, Ueda T, Ishii T, Araki N, Kito M
J Orthop Sci 2004;9(3):242-6. doi: 10.1007/s00776-004-0768-5. PMID: 15168177
Extraskeletal osteosarcoma with a highly malignant course. A case report.
Simank HG, Welkerling H, Bernd L, Ewerbeck V
Int Orthop 1995;19(4):251-4. doi: 10.1007/BF00185234. PMID: 8557425
Radiation-induced extraskeletal osteosarcoma.
Alpert LI, Abaci IF, Werthamer S
Cancer 1973 Jun;31(6):1359-63. doi: 10.1002/1097-0142(197306)31:6<1359::aid-cncr2820310609>3.0.co;2-f. PMID: 4350957

Prognosis

Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system.
Sparreboom BD, Trautman J, Yaxley J
J Med Imaging Radiat Oncol 2022 Sep;66(6):812-818. Epub 2022 Jul 16 doi: 10.1111/1754-9485.13456. PMID: 35842789
Extraosseous osteosarcoma: single institutional experience in Korea.
Lee S, Lee MR, Lee SJ, Ahn HK, Yi J, Yi SY, Seo SW, Sung KS, Park JO, Lee J
Asia Pac J Clin Oncol 2010 Jun;6(2):126-9. doi: 10.1111/j.1743-7563.2010.01278.x. PMID: 20565425
Whole-body MRI for detecting metastatic bone tumor: diagnostic value of diffusion-weighted images.
Nakanishi K, Kobayashi M, Nakaguchi K, Kyakuno M, Hashimoto N, Onishi H, Maeda N, Nakata S, Kuwabara M, Murakami T, Nakamura H
Magn Reson Med Sci 2007;6(3):147-55. doi: 10.2463/mrms.6.147. PMID: 18037795
Primary osteosarcoma of the breast.
Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, Katayama T, Ootoshi M, Fukumoto M
Breast Cancer 2004;11(4):396-400. doi: 10.1007/BF02968048. PMID: 15604996
Extraskeletal osteosarcoma with a highly malignant course. A case report.
Simank HG, Welkerling H, Bernd L, Ewerbeck V
Int Orthop 1995;19(4):251-4. doi: 10.1007/BF00185234. PMID: 8557425

Clinical prediction guides

Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system.
Sparreboom BD, Trautman J, Yaxley J
J Med Imaging Radiat Oncol 2022 Sep;66(6):812-818. Epub 2022 Jul 16 doi: 10.1111/1754-9485.13456. PMID: 35842789
Increased Prevalence of Malignancies in Fibrous Dysplasia/McCune-Albright Syndrome (FD/MAS): Data from a National Referral Center and the Dutch National Pathology Registry (PALGA).
Hagelstein-Rotman M, Meier ME, Majoor BCJ, Cleven AHG, Dijkstra PDS, Hamdy NAT, van de Sande MAJ, Dekkers OM, Appelman-Dijkstra NM
Calcif Tissue Int 2021 Mar;108(3):346-353. Epub 2020 Nov 23 doi: 10.1007/s00223-020-00780-6. PMID: 33226445
Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity.
Makise N, Sekimizu M, Kubo T, Wakai S, Watanabe SI, Kato T, Kinoshita T, Hiraoka N, Fukayama M, Kawai A, Ichikawa H, Yoshida A
Histopathology 2018 Jul;73(1):147-156. Epub 2018 Apr 19 doi: 10.1111/his.13506. PMID: 29489027
Whole-body MRI for detecting metastatic bone tumor: diagnostic value of diffusion-weighted images.
Nakanishi K, Kobayashi M, Nakaguchi K, Kyakuno M, Hashimoto N, Onishi H, Maeda N, Nakata S, Kuwabara M, Murakami T, Nakamura H
Magn Reson Med Sci 2007;6(3):147-55. doi: 10.2463/mrms.6.147. PMID: 18037795
Primary osteosarcoma of the breast.
Momoi H, Wada Y, Sarumaru S, Tamaki N, Gomi T, Kanaya S, Katayama T, Ootoshi M, Fukumoto M
Breast Cancer 2004;11(4):396-400. doi: 10.1007/BF02968048. PMID: 15604996

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