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Undifferentiated carcinoma of stomach

MedGen UID:
237029
Concept ID:
C1336858
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Stomach; anaplastic carcinoma of stomach; Anaplastic Carcinoma of the Stomach; anaplastic carcinoma of the stomach; Anaplastic Gastric Carcinoma; anaplastic gastric carcinoma; Gastric Undifferentiated Carcinoma; Gastric undifferentiated carcinoma; stomach undifferentiated carcinoma; Undifferentiated Carcinoma of Stomach; undifferentiated carcinoma of stomach; Undifferentiated Carcinoma of the Stomach; undifferentiated carcinoma of the stomach; undifferentiated gastric (stomach) cancer; Undifferentiated gastric carcinoma; Undifferentiated Gastric Carcinoma; undifferentiated gastric carcinoma; undifferentiated stomach adenocarcinoma
SNOMED CT: Undifferentiated gastric carcinoma (766757006); Undifferentiated carcinoma of stomach (766757006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018504
Orphanet: ORPHA423786

Definition

Undifferentiated carcinoma of stomach is a rare epithelial tumour of the stomach that lacks any features of differentiation beyond an epithelial phenotype. The presenting symptoms are usually vague and nonspecific, such as weight loss, anorexia, fatigue, epigastric pain and discomfort, heartburn and nausea, vomiting or hematemesis. Patients may also be asymptomatic. Ascites, jaundice, intestinal obstruction and peripheral lymphadenopathy indicate advanced stages and metastatic spread. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated carcinoma of stomach

Professional guidelines

PubMed

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Joshi SS, Badgwell BD
CA Cancer J Clin 2021 May;71(3):264-279. Epub 2021 Feb 16 doi: 10.3322/caac.21657. PMID: 33592120Free PMC Article
Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla JB, Caplin M, O'Toole D, Perren A; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):186-94. Epub 2016 Jan 5 doi: 10.1159/000443172. PMID: 26731334

Recent clinical studies

Etiology

Huang XB, Huang Q, Jiang MC, Zhong Q, Zheng HL, Wang JB, Huang ZN, Wang HG, Liu ZY, Li YF, Xu KX, Lin M, Li P, Huang ZH, Xie JW, Lin JX, Lu J, Que JW, Zheng CH, Chen QY, Huang CM
Gut 2024 Oct 7;73(11):1785-1798. doi: 10.1136/gutjnl-2023-331111. PMID: 38969490
Lumish MA, Walch H, Maron SB, Chatila W, Kemel Y, Maio A, Ku GY, Ilson DH, Won E, Li J, Joshi SS, Gu P, Schattner MA, Laszkowska M, Gerdes H, Jones DR, Sihag S, Coit DG, Tang LH, Strong VE, Molena D, Stadler ZK, Schultz N, Janjigian YY, Cercek A
J Natl Cancer Inst 2024 Feb 8;116(2):299-308. doi: 10.1093/jnci/djad186. PMID: 37699004Free PMC Article
Waldum HL, Fossmark R
Int J Mol Sci 2018 Dec 18;19(12) doi: 10.3390/ijms19124109. PMID: 30567376Free PMC Article
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article
Rice TW, Ishwaran H, Ferguson MK, Blackstone EH, Goldstraw P
J Thorac Oncol 2017 Jan;12(1):36-42. Epub 2016 Oct 31 doi: 10.1016/j.jtho.2016.10.016. PMID: 27810391Free PMC Article

Diagnosis

Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
AbdullGaffar B, Quraishi H
Int J Surg Pathol 2020 Sep;28(6):647-648. Epub 2019 Dec 10 doi: 10.1177/1066896919892691. PMID: 31822146
Waldum HL, Fossmark R
Int J Mol Sci 2018 Dec 18;19(12) doi: 10.3390/ijms19124109. PMID: 30567376Free PMC Article
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article

Therapy

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F, Gisbertz SS, Hannink G, Haveman JW, Heisterkamp J, Jansen W, Kouwenhoven EA, van Lanschot JJB, Nieuwenhuijzen GAP, van der Peet DL, Polat F, Ubels S, Wijnhoven BPL, Rovers MM, Rosman C; ICAN collaborative research group
JAMA Surg 2021 Jul 1;156(7):601-610. doi: 10.1001/jamasurg.2021.1555. PMID: 33978698Free PMC Article
Chung HC, Bang YJ, S Fuchs C, Qin SK, Satoh T, Shitara K, Tabernero J, Van Cutsem E, Alsina M, Cao ZA, Lu J, Bhagia P, Shih CS, Janjigian YY
Future Oncol 2021 Feb;17(5):491-501. Epub 2020 Nov 10 doi: 10.2217/fon-2020-0737. PMID: 33167735Free PMC Article
Magnusson J
Curr Surg 2006 Mar-Apr;63(2):96-100; quiz 100-1. doi: 10.1016/j.cursur.2005.10.005. PMID: 16520108

Prognosis

Neil AJ, Zhao L, Isidro RA, Srivastava A, Cleary JM, Dong F
Mod Pathol 2023 Jun;36(6):100183. Epub 2023 Apr 11 doi: 10.1016/j.modpat.2023.100183. PMID: 37054973
Ruan J, Xu J, Mao J
Gastroenterology 2023 Feb;164(2):e1-e3. Epub 2022 Aug 11 doi: 10.1053/j.gastro.2022.08.015. PMID: 35964696
Thongtan T, Deb A, Costilla V
Am J Med 2022 Jan;135(1):e14-e15. Epub 2021 Aug 14 doi: 10.1016/j.amjmed.2021.07.010. PMID: 34403703
Kong X, Wang JL, Chen HM, Fang JY
J Surg Oncol 2012 Sep 1;106(3):346-52. Epub 2012 Feb 13 doi: 10.1002/jso.23004. PMID: 22331676
CHAUNCEY LR
AMA Arch Surg 1954 Jun;68(6):872-85. doi: 10.1001/archsurg.1954.01260050874016. PMID: 13157790

Clinical prediction guides

Lumish MA, Walch H, Maron SB, Chatila W, Kemel Y, Maio A, Ku GY, Ilson DH, Won E, Li J, Joshi SS, Gu P, Schattner MA, Laszkowska M, Gerdes H, Jones DR, Sihag S, Coit DG, Tang LH, Strong VE, Molena D, Stadler ZK, Schultz N, Janjigian YY, Cercek A
J Natl Cancer Inst 2024 Feb 8;116(2):299-308. doi: 10.1093/jnci/djad186. PMID: 37699004Free PMC Article
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Ferreira RM, Pereira-Marques J, Pinto-Ribeiro I, Costa JL, Carneiro F, Machado JC, Figueiredo C
Gut 2018 Feb;67(2):226-236. Epub 2017 Nov 4 doi: 10.1136/gutjnl-2017-314205. PMID: 29102920Free PMC Article
Bailey C
BMJ Clin Evid 2008 Sep 3;2008 PMID: 19445803Free PMC Article

Recent systematic reviews

Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Li J, Pan J, Xiao D, Shen N, Wang R, Miao H, Pu P, Zhang H, Yv X, Xing L
J Transl Med 2024 May 6;22(1):429. doi: 10.1186/s12967-023-04736-w. PMID: 38711123Free PMC Article
Di Y, Ding L, Gao L, Huang H
BMC Cancer 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. PMID: 37612616Free PMC Article
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Yoon HH, Jin Z, Kour O, Kankeu Fonkoua LA, Shitara K, Gibson MK, Prokop LJ, Moehler M, Kang YK, Shi Q, Ajani JA
JAMA Oncol 2022 Oct 1;8(10):1456-1465. doi: 10.1001/jamaoncol.2022.3707. PMID: 36006624Free PMC Article

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