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Bladder urothelial papilloma

MedGen UID:
237227
•Concept ID:
C1384678
•
Neoplastic Process
Synonyms: Bladder Transitional Cell Papilloma; bladder transitional cell papilloma; Bladder Urothelial Papilloma; bladder urothelial papilloma; Urinary Bladder Transitional Cell Papilloma; urinary bladder transitional cell papilloma; Urinary Bladder Urothelial Papilloma; urinary bladder urothelial papilloma
 
Monarch Initiative: MONDO:0044906

Definition

A rare benign neoplasm that arises from the bladder and is characterized by the presence of a papillary growth with a central fibrovascular core. The latter is lined by normal urothelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder urothelial papilloma

Professional guidelines

PubMed

The Genitourinary Pathology Society Update on Classification and Grading of Flat and Papillary Urothelial Neoplasia With New Reporting Recommendations and Approach to Lesions With Mixed and Early Patterns of Neoplasia.
Amin MB, Comperat E, Epstein JI, True LD, Hansel D, Paner GP, Al-Ahmadie H, Baydar D, Bivalacqua T, Brimo F, Cheng L, Cheville J, Dalbagni G, Falzarano S, Gordetsky J, Guo CC, Gupta S, Hes O, Iyer G, Kaushal S, Kunju L, Magi-Galluzzi C, Matoso A, Netto G, Osunkoya AO, Pan CC, Pivovarcikova K, Raspollini MR, Reis H, Rosenberg J, Roupret M, Shah RB, Shariat S, Trpkov K, Weyerer V, Zhou M, McKenney J, Reuter VE
Adv Anat Pathol 2021 Jul 1;28(4):179-195. doi: 10.1097/PAP.0000000000000308. PMID: 34128483
Urothelial lesions with inverted growth patterns: histogenesis, molecular genetic findings, differential diagnosis and clinical management.
Hodges KB, Lopez-Beltran A, Maclennan GT, Montironi R, Cheng L
BJU Int 2011 Feb;107(4):532-7. Epub 2010 Nov 23 doi: 10.1111/j.1464-410X.2010.09853.x. PMID: 21091975
Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications.
Lopez-Beltran A, Cheng L
Hum Pathol 2006 Nov;37(11):1371-88. Epub 2006 Jul 31 doi: 10.1016/j.humpath.2006.05.009. PMID: 16949919

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

Recent clinical studies

Etiology

Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
MRI Findings of Inverted Urothelial Papilloma of the Bladder.
Takeuchi M, Sasaguri K, Naiki T, Mitsumori A, Ito H, Takahama J, Yamada K, Marugami N, Tsuboyama T, Okumura Y, Ohgiya Y, Kawai N, Kohri K, Shibamoto Y
AJR Am J Roentgenol 2015 Aug;205(2):311-6. doi: 10.2214/AJR.14.13879. PMID: 26204280
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573
Bladder cancer: clinical and pathological profile.
Lopez-Beltran A
Scand J Urol Nephrol Suppl 2008 Sep;(218):95-109. doi: 10.1080/03008880802325226. PMID: 18815924
Diagnosis and grading of bladder cancer and associated lesions.
Bostwick DG, Ramnani D, Cheng L
Urol Clin North Am 1999 Aug;26(3):493-507. doi: 10.1016/s0094-0143(05)70197-x. PMID: 10494287

Diagnosis

Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Mimickers of urothelial neoplasia.
Kryvenko ON, Epstein JI
Ann Diagn Pathol 2019 Feb;38:11-19. Epub 2018 Sep 26 doi: 10.1016/j.anndiagpath.2018.09.012. PMID: 30380401
Morphological diagnosis of urothelial neoplasms.
Montironi R, Mazzucchelli R, Scarpelli M, Lopez-Beltran A, Cheng L
J Clin Pathol 2008 Jan;61(1):3-10. Epub 2007 Jun 1 doi: 10.1136/jcp.2007.049312. PMID: 17545560
Nested variant of urothelial carcinoma.
Dhall D, Al-Ahmadie H, Olgac S
Arch Pathol Lab Med 2007 Nov;131(11):1725-7. doi: 10.5858/2007-131-1725-NVOUC. PMID: 17979494
Diagnosis and grading of bladder cancer and associated lesions.
Bostwick DG, Ramnani D, Cheng L
Urol Clin North Am 1999 Aug;26(3):493-507. doi: 10.1016/s0094-0143(05)70197-x. PMID: 10494287

Therapy

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Proteomic characterization of arsenic and cadmium exposure in bladder cells.
Chen YT, Ou Yang WT, Juang HH, Chen CL, Chen HW, Tsui KH, Chang YH, Tsai CH, Hsueh C, Liao WC
Rapid Commun Mass Spectrom 2020 Apr;34 Suppl 1:e8578. Epub 2020 Feb 8 doi: 10.1002/rcm.8578. PMID: 31499585
Urothelial carcinoma in children: A case series.
Marinoni F, Destro F, Selvaggio GGO, Riccipetitoni G
Bull Cancer 2018 Jun;105(6):556-561. Epub 2018 May 1 doi: 10.1016/j.bulcan.2018.03.002. PMID: 29724585
Transurethral Resection of the Bladder Tumour as a Treatment Method in Children with Transitional Cell Carcinoma of the Bladder--Analysis of Our Material and Literature Review.
Apoznański W, Rysiakiewicz J, Polok M, Rysiakiewicz K, Siekanowicz P, Hilger T, Zagierski J, Hilger M, Nowak I, Kolęda P, Szydełko T
Adv Clin Exp Med 2015 May-Jun;24(3):505-9. doi: 10.17219/acem/36600. PMID: 26467141
The prophylaxis of nonindustrial urothelial tumours.
Mount BM
Can Med Assoc J 1973 Jun 23;108(12):1531-2 passim. PMID: 4197537Free PMC Article

Prognosis

Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C
Nat Commun 2023 Sep 13;14(1):5670. doi: 10.1038/s41467-023-41139-3. PMID: 37704624Free PMC Article
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder.
Isharwal S, Hu W, Sarungbam J, Chen YB, Gopalan A, Fine SW, Tickoo SK, Sirintrapun SJ, Jadallah S, Loo FL, Pietzak EJ, Cha EK, Bochner BH, Berger MF, Iyer G, Solit DB, Reuter VE, Al-Ahmadie H
J Pathol 2019 Jul;248(3):260-265. Epub 2019 Apr 22 doi: 10.1002/path.5261. PMID: 30838648Free PMC Article
A clinical and molecular review of inverted papilloma of the urinary tract: how to handle?
Jørgensen PH, Vainer B, Hermann GG
APMIS 2015 Nov;123(11):920-9. Epub 2015 Sep 11 doi: 10.1111/apm.12456. PMID: 26358542
Pathology and staging of urothelial tumors of the kidney and ureter.
Melamed MR, Reuter VE
Urol Clin North Am 1993 May;20(2):333-47. PMID: 8388136

Clinical prediction guides

RAS Family Gene Mutations, Clinicopathological Features, and Spread Patterns of Inverted Urothelial Papilloma of the Bladder.
Kitahama K, Shigematsu Y, Amori G, Sugawara E, Yonese J, Shibahara J, Takeuchi K, Inamura K
Am J Surg Pathol 2024 Apr 1;48(4):458-464. Epub 2023 Dec 25 doi: 10.1097/PAS.0000000000002171. PMID: 38145408
Young population bladder neoplasms.
Çivi Çetin K, Öner S, Erdoğan B, Simşek G, Sezer M
Eur Rev Med Pharmacol Sci 2023 Nov;27(21):10454-10461. doi: 10.26355/eurrev_202311_34320. PMID: 37975369
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article
Urothelial neoplasia.
Murphy WM
Monogr Pathol 1992;(34):77-111. PMID: 1406745

Recent systematic reviews

Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

    Consumer resources

    Reviews

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