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Arthrogryposis

MedGen UID:
2455
Concept ID:
C0003886
Disease or Syndrome; Finding
Synonyms: Arthrogryposes, congenital multiple; arthrogryposis; congenital multiple Arthrogryposes; congenital multiple arthrogryposis
SNOMED CT: Arthrogryposis (111246005)
 
Monarch Initiative: MONDO:0008779

Definition

A rare, non-progressive congenital disorder characterized by multiple joint contractures which are present at birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVArthrogryposis
Follow this link to review classifications for Arthrogryposis in Orphanet.

Professional guidelines

PubMed

Ravenscroft G, Clayton JS, Faiz F, Sivadorai P, Milnes D, Cincotta R, Moon P, Kamien B, Edwards M, Delatycki M, Lamont PJ, Chan SH, Colley A, Ma A, Collins F, Hennington L, Zhao T, McGillivray G, Ghedia S, Chao K, O'Donnell-Luria A, Laing NG, Davis MR
J Med Genet 2021 Sep;58(9):609-618. Epub 2020 Oct 15 doi: 10.1136/jmedgenet-2020-106901. PMID: 33060286Free PMC Article
Savarese M, Vihola A, Oates EC, Barresi R, Fiorillo C, Tasca G, Jokela M, Sarkozy A, Luo S, Díaz-Manera J, Ehrstedt C, Rojas-García R, Sáenz A, Muelas N, Lonardo F, Fodstad H, Qureshi T, Johari M, Välipakka S, Luque H, Petiot P, de Munain AL, Pane M, Mercuri E, Torella A, Nigro V, Astrea G, Santorelli FM, Bruno C, Kuntzer T, Illa I, Vílchez JJ, Julien C, Ferreiro A, Malandrini A, Zhao CB, Casar-Borota O, Davis M, Muntoni F, Hackman P, Udd B
Genet Med 2020 Dec;22(12):2029-2040. Epub 2020 Aug 11 doi: 10.1038/s41436-020-0914-2. PMID: 32778822
Rodriguez LM, Bickley C, Russo S, Barnes D, Gagnon M, Hamdy R, Veilleux LN
Am J Med Genet C Semin Med Genet 2019 Sep;181(3):404-409. Epub 2019 Jul 29 doi: 10.1002/ajmg.c.31728. PMID: 31359604

Recent clinical studies

Etiology

Filges I, Jünemann S, Viehweger E, Tercanli S
Prenat Diagn 2023 Jun;43(6):798-805. Epub 2023 Jan 12 doi: 10.1002/pd.6299. PMID: 36588183
Hall JG, Kimber E, van Bosse HJP
J Pediatr Orthop 2017 Jul/Aug;37 Suppl 1:S4-S8. doi: 10.1097/BPO.0000000000000997. PMID: 28594686
van Bosse HJ
Foot Ankle Clin 2015 Dec;20(4):619-44. Epub 2015 Oct 21 doi: 10.1016/j.fcl.2015.07.010. PMID: 26589082
Zekanowski C, Religa D, Graff C, Filipek S, Kuźnicki J
Acta Neurobiol Exp (Wars) 2004;64(1):19-31. doi: 10.55782/ane-2004-1488. PMID: 15190677
Preus M, Fraser FC
Am J Dis Child 1972 Dec;124(6):933-43. doi: 10.1001/archpedi.1972.02110180135022. PMID: 4265019

Diagnosis

Langston S, Chu A
Pediatr Ann 2020 Jul 1;49(7):e299-e304. doi: 10.3928/19382359-20200624-01. PMID: 32674167
Attarian S, Fatehi F, Rajabally YA, Pareyson D
J Neurol 2020 Aug;267(8):2198-2206. Epub 2019 Apr 15 doi: 10.1007/s00415-019-09319-8. PMID: 30989370
Society for Maternal-Fetal Medicine, Rac MWF, McKinney J, Gandhi M
Am J Obstet Gynecol 2019 Dec;221(6):B7-B9. doi: 10.1016/j.ajog.2019.09.021. PMID: 31787162
Hall JG, Kimber E, Dieterich K
Am J Med Genet C Semin Med Genet 2019 Sep;181(3):300-303. Epub 2019 Jul 4 doi: 10.1002/ajmg.c.31716. PMID: 31271512
Hall JG, Kimber E, van Bosse HJP
J Pediatr Orthop 2017 Jul/Aug;37 Suppl 1:S4-S8. doi: 10.1097/BPO.0000000000000997. PMID: 28594686

Therapy

Thakker A, Sharma SC, Hussain NM, Devani P, Lahiri A
J Plast Reconstr Aesthet Surg 2021 Mar;74(3):549-559. Epub 2020 Nov 8 doi: 10.1016/j.bjps.2020.10.085. PMID: 33268044
Anderson TA, Kasser JR, Holzman RS
Paediatr Anaesth 2014 May;24(5):538-40. doi: 10.1111/pan.12303. PMID: 24829975
Benca J, Hogan K
Anesth Analg 2009 Oct;109(4):1049-53. doi: 10.1213/ane.0b013e3181adca28. PMID: 19762731
Dinger J, Prager B
Neuromuscul Disord 1993 Jul;3(4):335-9. doi: 10.1016/0960-8966(93)90027-h. PMID: 8268731
Barlow CF
Am J Dis Child 1981 Mar;135(3):209. doi: 10.1001/archpedi.1981.02130270001001. PMID: 7211772

Prognosis

Langston S, Chu A
Pediatr Ann 2020 Jul 1;49(7):e299-e304. doi: 10.3928/19382359-20200624-01. PMID: 32674167
Society for Maternal-Fetal Medicine, Rac MWF, McKinney J, Gandhi M
Am J Obstet Gynecol 2019 Dec;221(6):B7-B9. doi: 10.1016/j.ajog.2019.09.021. PMID: 31787162
Mutlu M, Aslan Y, Aktürk-Acar F, Çakır M, Erduran E, Kalyoncu M
Turk J Pediatr 2017;59(4):487-490. doi: 10.24953/turkjped.2017.04.019. PMID: 29624233
Mennen U, van Heest A, Ezaki MB, Tonkin M, Gericke G
J Hand Surg Br 2005 Oct;30(5):468-74. doi: 10.1016/j.jhsb.2005.06.004. PMID: 16061316
Sztriha L, Al-Gazali L, Várady E, Nork M, Varughese M
Pediatr Neurol 1998 Apr;18(4):362-5. doi: 10.1016/s0887-8994(97)00213-0. PMID: 9588537

Clinical prediction guides

Saffari A, Lau T, Tajsharghi H, Karimiani EG, Kariminejad A, Efthymiou S, Zifarelli G, Sultan T, Toosi MB, Sedighzadeh S, Siu VM, Ortigoza-Escobar JD, AlShamsi AM, Ibrahim S, Al-Sannaa NA, Al-Hertani W, Sandra W, Tarnopolsky M, Alavi S, Li C, Day-Salvatore DL, Martínez-González MJ, Levandoski KM, Bedoukian E, Madan-Khetarpal S, Idleburg MJ, Menezes MJ, Siddharth A, Platzer K, Oppermann H, Smitka M, Collins F, Lek M, Shahrooei M, Ghavideldarestani M, Herman I, Rendu J, Faure J, Baker J, Bhambhani V, Calderwood L, Akhondian J, Imannezhad S, Mirzadeh HS, Hashemi N, Doosti M, Safi M, Ahangari N, Torbati PN, Abedini S, Salpietro V, Gulec EY, Eshaghian S, Ghazavi M, Pascher MT, Vogel M, Abicht A, Moutton S, Bruel AL, Rieubland C, Gallati S, Strom TM, Lochmüller H, Mohammadi MH, Alvi JR, Zackai EH, Keena BA, Skraban CM, Berger SI, Andrew EH, Rahimian E, Morrow MM, Wentzensen IM, Millan F, Henderson LB, Dafsari HS, Jungbluth H, Gomez-Ospina N, McRae A, Peter M, Veltra D, Marinakis NM, Sofocleous C, Ashrafzadeh F, Pehlivan D, Lemke JR, Melki J, Benezit A, Bauer P, Weis D, Lupski JR, Senderek J, Christodoulou J, Chung WK, Goodchild R, Offiah AC, Moreno-De-Luca A, Suri M, Ebrahimi-Fakhari D, Houlden H, Maroofian R
Brain 2023 Aug 1;146(8):3273-3288. doi: 10.1093/brain/awad039. PMID: 36757831Free PMC Article
Laquerriere A, Jaber D, Abiusi E, Maluenda J, Mejlachowicz D, Vivanti A, Dieterich K, Stoeva R, Quevarec L, Nolent F, Biancalana V, Latour P, Sternberg D, Capri Y, Verloes A, Bessieres B, Loeuillet L, Attie-Bitach T, Martinovic J, Blesson S, Petit F, Beneteau C, Whalen S, Marguet F, Bouligand J, Héron D, Viot G, Amiel J, Amram D, Bellesme C, Bucourt M, Faivre L, Jouk PS, Khung S, Sigaudy S, Delezoide AL, Goldenberg A, Jacquemont ML, Lambert L, Layet V, Lyonnet S, Munnich A, Van Maldergem L, Piard J, Guimiot F, Landrieu P, Letard P, Pelluard F, Perrin L, Saint-Frison MH, Topaloglu H, Trestard L, Vincent-Delorme C, Amthor H, Barnerias C, Benachi A, Bieth E, Boucher E, Cormier-Daire V, Delahaye-Duriez A, Desguerre I, Eymard B, Francannet C, Grotto S, Lacombe D, Laffargue F, Legendre M, Martin-Coignard D, Mégarbané A, Mercier S, Nizon M, Rigonnot L, Prieur F, Quélin C, Ranjatoelina-Randrianaivo H, Resta N, Toutain A, Verhelst H, Vincent M, Colin E, Fallet-Bianco C, Granier M, Grigorescu R, Saada J, Gonzales M, Guiochon-Mantel A, Bessereau JL, Tawk M, Gut I, Gitiaux C, Melki J
J Med Genet 2022 Jun;59(6):559-567. Epub 2021 Apr 5 doi: 10.1136/jmedgenet-2020-107595. PMID: 33820833Free PMC Article
Vetro A, Nielsen HN, Holm R, Hevner RF, Parrini E, Powis Z, Møller RS, Bellan C, Simonati A, Lesca G, Helbig KL, Palmer EE, Mei D, Ballardini E, Van Haeringen A, Syrbe S, Leuzzi V, Cioni G, Curry CJ, Costain G, Santucci M, Chong K, Mancini GMS, Clayton-Smith J, Bigoni S, Scheffer IE, Dobyns WB, Vilsen B, Guerrini R; ATP1A2/A3-collaborators
Brain 2021 Jun 22;144(5):1435-1450. doi: 10.1093/brain/awab052. PMID: 33880529
Ravenscroft G, Clayton JS, Faiz F, Sivadorai P, Milnes D, Cincotta R, Moon P, Kamien B, Edwards M, Delatycki M, Lamont PJ, Chan SH, Colley A, Ma A, Collins F, Hennington L, Zhao T, McGillivray G, Ghedia S, Chao K, O'Donnell-Luria A, Laing NG, Davis MR
J Med Genet 2021 Sep;58(9):609-618. Epub 2020 Oct 15 doi: 10.1136/jmedgenet-2020-106901. PMID: 33060286Free PMC Article
Poling MI, Dufresne CR, Chamberlain RL
Orphanet J Rare Dis 2019 Jan 10;14(1):14. doi: 10.1186/s13023-018-0984-2. PMID: 30630514Free PMC Article

Recent systematic reviews

Erden M, Uyanik E, Demeestere I, Oktay KH
Am J Obstet Gynecol 2024 Nov;231(5):480-489. Epub 2024 Apr 15 doi: 10.1016/j.ajog.2024.04.012. PMID: 38621483Free PMC Article
Taqi D, Nematollahi S, Lemin S, Rauch F, Hamdy R, Dahan-Oliel N
Bone 2024 Feb;179:116955. Epub 2023 Nov 10 doi: 10.1016/j.bone.2023.116955. PMID: 37951521
Chergui S, Al-Ali H, Marwan Y, Abu Dalu K, Dahan-Oliel N, Hamdy RC
Foot Ankle Surg 2023 Jan;29(1):15-21. Epub 2022 Oct 15 doi: 10.1016/j.fas.2022.10.002. PMID: 36266132
Freitas DA, Souza-Santos R, Carvalho LMA, Barros WB, Neves LM, Brasil P, Wakimoto MD
PLoS One 2020;15(12):e0242367. Epub 2020 Dec 15 doi: 10.1371/journal.pone.0242367. PMID: 33320867Free PMC Article
Sun C, Xu D, Pei Z, Yang L, Qiao Z, Lu W, Luo F, Qiu Z
Birth Defects Res 2020 Dec;112(20):1834-1842. Epub 2020 Oct 8 doi: 10.1002/bdr2.1814. PMID: 33030311

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