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Functional cyst of ovary

MedGen UID:
256156
•Concept ID:
C1142385
•
Anatomical Abnormality
Synonyms: Functional Cyst of Ovary; Functional Cyst of the Ovary; Functional ovarian cyst; Functional Ovarian Cyst
SNOMED CT: Functional ovarian cyst (116341001); Functional cyst of ovary (116341001)

Definition

A benign ovarian cyst that develops and regresses during the menstrual cycle as part of normal ovarian function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFunctional cyst of ovary

Professional guidelines

PubMed

Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS Network
Eur J Endocrinol 2023 Aug 2;189(2):G43-G64. doi: 10.1093/ejendo/lvad096. PMID: 37580861
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE
J Clin Endocrinol Metab 2023 Sep 18;108(10):2447-2469. doi: 10.1210/clinem/dgad463. PMID: 37580314Free PMC Article
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing.
Sadeghi HM, Adeli I, Calina D, Docea AO, Mousavi T, Daniali M, Nikfar S, Tsatsakis A, Abdollahi M
Int J Mol Sci 2022 Jan 6;23(2) doi: 10.3390/ijms23020583. PMID: 35054768Free PMC Article

Recent clinical studies

Etiology

Pathophysiology and Clinical Implications of Ovarian Endometriomas.
Nezhat FR, Cathcart AM, Nezhat CH, Nezhat CR
Obstet Gynecol 2024 Jun 1;143(6):759-766. Epub 2024 Apr 16 doi: 10.1097/AOG.0000000000005587. PMID: 38626453Free PMC Article
Ovarian torsion in pediatric and adolescent patients: A systematic review.
Dasgupta R, Renaud E, Goldin AB, Baird R, Cameron DB, Arnold MA, Diefenbach KA, Gosain A, Grabowski J, Guner YS, Jancelewicz T, Kawaguchi A, Lal DR, Oyetunji TA, Ricca RL, Shelton J, Somme S, Williams RF, Downard CD
J Pediatr Surg 2018 Jul;53(7):1387-1391. Epub 2017 Nov 16 doi: 10.1016/j.jpedsurg.2017.10.053. PMID: 29153467
Management of Endometriomas.
Muzii L, Di Tucci C, Di Feliciantonio M, Galati G, Verrelli L, Donato VD, Marchetti C, Panici PB
Semin Reprod Med 2017 Jan;35(1):25-30. Epub 2016 Dec 7 doi: 10.1055/s-0036-1597126. PMID: 27926971
Diagnosis and management of ovarian cyst accidents.
Bottomley C, Bourne T
Best Pract Res Clin Obstet Gynaecol 2009 Oct;23(5):711-24. Epub 2009 Mar 18 doi: 10.1016/j.bpobgyn.2009.02.001. PMID: 19299205
Conformations of blood group H-active oligosaccharides of ovarian cyst mucins.
Rao BN, Dua VK, Bush CA
Biopolymers 1985 Dec;24(12):2207-29. doi: 10.1002/bip.360241205. PMID: 4092088

Diagnosis

Pathophysiology and Clinical Implications of Ovarian Endometriomas.
Nezhat FR, Cathcart AM, Nezhat CH, Nezhat CR
Obstet Gynecol 2024 Jun 1;143(6):759-766. Epub 2024 Apr 16 doi: 10.1097/AOG.0000000000005587. PMID: 38626453Free PMC Article
Single-cell analysis of endometriosis reveals a coordinated transcriptional programme driving immunotolerance and angiogenesis across eutopic and ectopic tissues.
Tan Y, Flynn WF, Sivajothi S, Luo D, Bozal SB, Davé M, Luciano AA, Robson P, Luciano DE, Courtois ET
Nat Cell Biol 2022 Aug;24(8):1306-1318. Epub 2022 Jul 21 doi: 10.1038/s41556-022-00961-5. PMID: 35864314Free PMC Article
Ovarian cysts.
Society for Maternal-Fetal Medicine (SMFM), Cheng Y
Am J Obstet Gynecol 2021 Nov;225(5):B23-B25. Epub 2021 Sep 8 doi: 10.1016/j.ajog.2021.06.042. PMID: 34507793
Ovarian Cysts in the Bitch: An Update.
Sasidharan JK, Patra MK, Singh LK, Saxena AC, De UK, Singh V, Mathesh K, Kumar H, Krishnaswamy N
Top Companion Anim Med 2021 Jun;43:100511. Epub 2021 Jan 9 doi: 10.1016/j.tcam.2021.100511. PMID: 33434678
Diagnosis and management of ovarian cyst accidents.
Bottomley C, Bourne T
Best Pract Res Clin Obstet Gynaecol 2009 Oct;23(5):711-24. Epub 2009 Mar 18 doi: 10.1016/j.bpobgyn.2009.02.001. PMID: 19299205

Therapy

Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.
Kite C, Lahart IM, Afzal I, Broom DR, Randeva H, Kyrou I, Brown JE
Syst Rev 2019 Feb 12;8(1):51. doi: 10.1186/s13643-019-0962-3. PMID: 30755271Free PMC Article
Pharmacologic Treatment of Polycystic Ovary Syndrome: Alternate and Future Paths.
Duguech LMM, Legro RS
Semin Reprod Med 2017 Jul;35(4):326-343. Epub 2017 Oct 16 doi: 10.1055/s-0037-1603729. PMID: 29036740
The contraceptive implant.
Hohmann H, Creinin MD
Clin Obstet Gynecol 2007 Dec;50(4):907-17. doi: 10.1097/GRF.0b013e318159c2f6. PMID: 17982333
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).
Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Hum Reprod 2004 Jan;19(1):41-7. doi: 10.1093/humrep/deh098. PMID: 14688154
Clomiphene.
Bishop PM
Br Med Bull 1970 Jan;26(1):22-5. doi: 10.1093/oxfordjournals.bmb.a070737. PMID: 4904682

Prognosis

Ovarian cysts.
Society for Maternal-Fetal Medicine (SMFM), Cheng Y
Am J Obstet Gynecol 2021 Nov;225(5):B23-B25. Epub 2021 Sep 8 doi: 10.1016/j.ajog.2021.06.042. PMID: 34507793
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Kumariya S, Ubba V, Jha RK, Gayen JR
Autophagy 2021 Oct;17(10):2706-2733. Epub 2021 Jun 23 doi: 10.1080/15548627.2021.1938914. PMID: 34161185Free PMC Article
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.
Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH
Endocr Rev 2020 Jul 1;41(4) doi: 10.1210/endrev/bnaa010. PMID: 32310267Free PMC Article
Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R
Fertil Steril 2016 Jul;106(1):6-15. Epub 2016 May 24 doi: 10.1016/j.fertnstert.2016.05.003. PMID: 27233760
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.
Dunaif A
Endocr Rev 1997 Dec;18(6):774-800. doi: 10.1210/edrv.18.6.0318. PMID: 9408743

Clinical prediction guides

Pathophysiology and Clinical Implications of Ovarian Endometriomas.
Nezhat FR, Cathcart AM, Nezhat CH, Nezhat CR
Obstet Gynecol 2024 Jun 1;143(6):759-766. Epub 2024 Apr 16 doi: 10.1097/AOG.0000000000005587. PMID: 38626453Free PMC Article
Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.
Kumariya S, Ubba V, Jha RK, Gayen JR
Autophagy 2021 Oct;17(10):2706-2733. Epub 2021 Jun 23 doi: 10.1080/15548627.2021.1938914. PMID: 34161185Free PMC Article
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.
Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH
Endocr Rev 2020 Jul 1;41(4) doi: 10.1210/endrev/bnaa010. PMID: 32310267Free PMC Article
Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R
Fertil Steril 2016 Jul;106(1):6-15. Epub 2016 May 24 doi: 10.1016/j.fertnstert.2016.05.003. PMID: 27233760
Polycystic ovary syndrome: etiology, pathogenesis and diagnosis.
Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R
Nat Rev Endocrinol 2011 Apr;7(4):219-31. Epub 2011 Jan 25 doi: 10.1038/nrendo.2010.217. PMID: 21263450

Recent systematic reviews

Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines.
Fitz V, Graca S, Mahalingaiah S, Liu J, Lai L, Butt A, Armour M, Rao V, Naidoo D, Maunder A, Yang G, Vaddiparthi V, Witchel SF, Pena A, Spritzer PM, Li R, Tay C, Mousa A, Teede H, Ee C
J Clin Endocrinol Metab 2024 May 17;109(6):1630-1655. doi: 10.1210/clinem/dgad762. PMID: 38163998Free PMC Article
Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM
Reprod Biol Endocrinol 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143Free PMC Article
Life Modifications and PCOS: Old Story But New Tales.
Gu Y, Zhou G, Zhou F, Wu Q, Ma C, Zhang Y, Ding J, Hua K
Front Endocrinol (Lausanne) 2022;13:808898. Epub 2022 Apr 13 doi: 10.3389/fendo.2022.808898. PMID: 35498415Free PMC Article
Dietary Modification for Reproductive Health in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
Shang Y, Zhou H, He R, Lu W
Front Endocrinol (Lausanne) 2021;12:735954. Epub 2021 Nov 1 doi: 10.3389/fendo.2021.735954. PMID: 34790167Free PMC Article
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article

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