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Metanephric adenoma

MedGen UID:
266093
•Concept ID:
C1266045
•
Neoplastic Process
Synonyms: Kidney Embryonal Adenoma; Metanephric Adenoma; metanephric adenoma; metanephric adenoma (morphologic abnormality)
SNOMED CT: Metanephric adenoma (128670007)
 
Monarch Initiative: MONDO:0006301

Definition

A benign, well-circumscribed renal cortical neoplasm affecting females more often than males. Polycythemia has been reported in twelve-percent of patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetanephric adenoma

Professional guidelines

PubMed

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.
Sarlos DP, Banyai D, Peterfi L, Szanto A, Kovacs G
Anticancer Res 2018 Dec;38(12):6663-6667. doi: 10.21873/anticanres.13033. PMID: 30504374
Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma.
Kinney SN, Eble JN, Hes O, Williamson SR, Grignon DJ, Wang M, Zhang S, Baldrige LA, Martignoni G, Brunelli M, Wang L, Comperat E, Fan R, Montironi R, MacLennan GT, Cheng L
Mod Pathol 2015 Sep;28(9):1236-48. Epub 2015 Aug 7 doi: 10.1038/modpathol.2015.81. PMID: 26248896
Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
Olgac S, Hutchinson B, Tickoo SK, Reuter VE
Mod Pathol 2006 Feb;19(2):218-24. doi: 10.1038/modpathol.3800520. PMID: 16424894

Recent clinical studies

Etiology

Renal cell carcinoma in children and adolescents: a retrospective study of a French-Italian series of 93 cases.
Denize T, Massa S, Valent A, Militti L, Bertolotti A, Barisella M, Rioux-Leclercq N, Malouf GG, Spreafico F, Verschuur A, van der Beek J, Tytgat L, van den Heuvel-Eibrink MM, Vujanic G, Collini P, Coulomb A
Histopathology 2022 May;80(6):928-945. Epub 2022 Mar 22 doi: 10.1111/his.14634. PMID: 35238063
Key Renal Neoplasms With a Female Predominance.
Baniak N, Barletta JA, Hirsch MS
Adv Anat Pathol 2021 Jul 1;28(4):228-250. doi: 10.1097/PAP.0000000000000301. PMID: 34009777
The history of urologic pathology: an overview.
Young RH, Eble JN
Histopathology 2019 Jan;74(1):184-212. doi: 10.1111/his.13753. PMID: 30565309
Novel clinicopathological and molecular characterization of metanephric adenoma: a study of 28 cases.
Ding Y, Wang C, Li X, Jiang Y, Mei P, Huang W, Song G, Wang J, Ping G, Hu R, Miao C, He X, Chen G, Li H, Zhu Y, Zhang Z
Diagn Pathol 2018 Aug 16;13(1):54. doi: 10.1186/s13000-018-0732-x. PMID: 30111351Free PMC Article
The clinical and CT imaging features of metanephric adenoma.
Zhu Q, Zhu W, Wu J, Chen W, Wang S
Acta Radiol 2014 Mar;55(2):231-8. Epub 2013 Jul 24 doi: 10.1177/0284185113493411. PMID: 23884840

Diagnosis

Metanephric adenoma: molecular study and review of the literature.
Rodríguez-Zarco E, Machuca-Aguado J, Macías-García L, Vallejo-Benítez A, Ríos-Martín JJ
Oncotarget 2022;13:387-392. Epub 2022 Feb 17 doi: 10.18632/oncotarget.28192. PMID: 35198098Free PMC Article
The history of urologic pathology: an overview.
Young RH, Eble JN
Histopathology 2019 Jan;74(1):184-212. doi: 10.1111/his.13753. PMID: 30565309
Unusual benign solid neoplasms of the kidney: cross-sectional imaging findings.
Karaosmanoğlu AD, Onur MR, Shirkhoda A, Ozmen M, Hahn PF
Diagn Interv Radiol 2015 Sep-Oct;21(5):376-81. doi: 10.5152/dir.2015.14545. PMID: 26200482Free PMC Article
CT and ultrasound findings of metanephric adenoma: a report of two cases and literature review.
Zhang LJ, Yang GF, Shen W, Lu GM
Br J Radiol 2011 Mar;84(999):e51-4. doi: 10.1259/bjr/62994226. PMID: 21325357Free PMC Article
Adult mesoblastic nephroma.
Daniel L, Lechevallier E, Bouvier C, Coulange C, Pellissier JF
Pathol Res Pract 2000;196(2):135-9. doi: 10.1016/S0344-0338(00)80046-1. PMID: 10707372

Therapy

Secondary renal neoplasia following chemotherapy or radiation in pediatric patients.
Gupta S, Vanderbilt CM, Leibovich BC, Herrera-Hernandez L, Raghunathan A, Sukov WR, Voss JS, Barr Fritcher EG, Reed KA, Lohse CM, Reuter VE, Jimenez RE, Thompson RH, Cheville JC
Hum Pathol 2020 Sep;103:1-13. Epub 2020 Jul 15 doi: 10.1016/j.humpath.2020.07.014. PMID: 32681944Free PMC Article
Robotic-assisted laparoscopic surgery for pediatric tumors: a bicenter experience.
Meignan P, Ballouhey Q, Lejeune J, Braik K, Longis B, Cook AR, Lardy H, Fourcade L, Binet A
J Robot Surg 2018 Sep;12(3):501-508. Epub 2017 Dec 29 doi: 10.1007/s11701-017-0773-2. PMID: 29288372
Chimerism of metanephric adenoma but not of carcinoma in kidney transplants.
Mengel M, Jonigk D, Wilkens L, Radermacher J, von Wasielewski R, Lehmann U, Haller H, Mihatsch M, Kreipe H
Am J Pathol 2004 Dec;165(6):2079-85. doi: 10.1016/S0002-9440(10)63258-0. PMID: 15579450Free PMC Article
Pure cystic nephroblastoma of the ovary with a review of extrarenal Wilms' tumors.
Isaac MA, Vijayalakshmi S, Madhu CS, Bosincu L, Nogales FF
Hum Pathol 2000 Jun;31(6):761-4. doi: 10.1053/hupa.2000.7627. PMID: 10872672
Metanephric adenofibroma: report of a case and review of the literature.
Shek TW, Luk IS, Peh WC, Chan KL, Chan GC
Am J Surg Pathol 1999 Jun;23(6):727-33. doi: 10.1097/00000478-199906000-00014. PMID: 10366157

Prognosis

Metanephric adenoma an unusual renal mass: A rare case.
Anshu A, Kumar A
Trop Doct 2023 Jul;53(3):400-401. Epub 2023 Apr 5 doi: 10.1177/00494755231164793. PMID: 37016960
Metanephric adenoma: molecular study and review of the literature.
Rodríguez-Zarco E, Machuca-Aguado J, Macías-García L, Vallejo-Benítez A, Ríos-Martín JJ
Oncotarget 2022;13:387-392. Epub 2022 Feb 17 doi: 10.18632/oncotarget.28192. PMID: 35198098Free PMC Article
Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma.
Sun Z, Kan S, Zhang L, Zhang Y, Jing H, Huang G, Yu Q, Wu J
Int J Clin Exp Pathol 2015;8(6):6031-6. Epub 2015 Jun 1 PMID: 26261480Free PMC Article
Unusual benign solid neoplasms of the kidney: cross-sectional imaging findings.
Karaosmanoğlu AD, Onur MR, Shirkhoda A, Ozmen M, Hahn PF
Diagn Interv Radiol 2015 Sep-Oct;21(5):376-81. doi: 10.5152/dir.2015.14545. PMID: 26200482Free PMC Article
Incidence of benign pathologic findings at partial nephrectomy for solitary renal mass presumed to be renal cell carcinoma on preoperative imaging.
Kutikov A, Fossett LK, Ramchandani P, Tomaszewski JE, Siegelman ES, Banner MP, Van Arsdalen KN, Wein AJ, Malkowicz SB
Urology 2006 Oct;68(4):737-40. doi: 10.1016/j.urology.2006.04.011. PMID: 17070344

Clinical prediction guides

Metanephric adenoma an unusual renal mass: A rare case.
Anshu A, Kumar A
Trop Doct 2023 Jul;53(3):400-401. Epub 2023 Apr 5 doi: 10.1177/00494755231164793. PMID: 37016960
The history of urologic pathology: an overview.
Young RH, Eble JN
Histopathology 2019 Jan;74(1):184-212. doi: 10.1111/his.13753. PMID: 30565309
The findings of CT and MRI in patients with metanephric adenoma.
Yan J, Cheng JL, Li CF, Lian YB, Zheng Y, Zhang XP, Wang CY
Diagn Pathol 2016 Oct 27;11(1):104. doi: 10.1186/s13000-016-0535-x. PMID: 27784295Free PMC Article
Immunohistochemical phenotype and molecular pathological characteristics of metanephric adenoma.
Sun Z, Kan S, Zhang L, Zhang Y, Jing H, Huang G, Yu Q, Wu J
Int J Clin Exp Pathol 2015;8(6):6031-6. Epub 2015 Jun 1 PMID: 26261480Free PMC Article
Adult metanephric adenoma presumed to be all benign? A clinical perspective.
Li G, Tang Y, Zhang R, Song H, Zhang S, Niu Y
BMC Cancer 2015 Apr 25;15:310. doi: 10.1186/s12885-015-1211-3. PMID: 25907695Free PMC Article

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