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Eccrine syringofibroadenoma

MedGen UID:
266096
•Concept ID:
C1266060
•
Neoplastic Process
Synonym: Syringofibroadenoma
SNOMED CT: Eccrine syringofibroadenoma (403936002); Eccrine syringofibroadenoma of skin (403936002); Syringofibroadenoma (403936002); Syringofibroadenoma (128684002); Acrosyringeal nevus (239117002)
 
HPO: HP:0031018
Monarch Initiative: MONDO:0024246

Definition

Eccrine syringofibroadenoma (ESFA) is a benign adnexal tumor arising most often on the extremities of elderly individuals characterized by anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells and ductal structures. ESFA stains positively with epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEccrine syringofibroadenoma

Professional guidelines

PubMed

Intraepidermal Poroma (Hidroacanthoma Simplex) Versus Clonal Seborrheic Keratosis: Will GATA3 Immunohistochemistry Help in the Differential Diagnosis?
Schukow C, McCalmont TH, Surprenant D, Yang HH
Am J Dermatopathol 2023 Oct 1;45(10):728-730. Epub 2023 Jul 28 doi: 10.1097/DAD.0000000000002503. PMID: 37506277
Expression of lumican in hidroacanthoma simplex and clonal-type seborrheic keratosis as a potent differential diagnostic marker.
Takayama R, Ansai S, Ishiwata T, Yamamoto T, Matsuda Y, Naito Z, Kawana S
Am J Dermatopathol 2014 Aug;36(8):655-60. doi: 10.1097/DAD.0b013e31828b6bbf. PMID: 23656908
Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation.
Aslan F, Demirkesen C, Cağatay P, Tüzüner N
J Cutan Pathol 2006 Aug;33(8):531-8. doi: 10.1111/j.1600-0560.2006.00466.x. PMID: 16919026

Recent clinical studies

Etiology

Multiple Eccrine Syringofibroadenoma of Mascaro of the Lower Extremity.
Lowell DL, Salvo NL, Weily WJ, Swiatek M, Sahli H
J Am Podiatr Med Assoc 2016 Nov;106(6):433-438. doi: 10.7547/15-066. PMID: 28033055
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Schöpf-Schulz-Passarge syndrome: further delineation of the phenotype and genetic considerations.
Castori M, Ruggieri S, Giannetti L, Annessi G, Zambruno G
Acta Derm Venereol 2008;88(6):607-12. doi: 10.2340/00015555-0547. PMID: 19002348
Leprosy-associated eccrine syringofibroadenoma of Mascaro.
Tey HL, Chong WS, Wong SN
Clin Exp Dermatol 2007 Sep;32(5):533-5. Epub 2007 Apr 24 doi: 10.1111/j.1365-2230.2007.02434.x. PMID: 17459067
Eccrine syringofibroadenoma: case report and review of the literature.
Takeda H, Mitsuhashi Y, Hayashi M, Kondo S
J Eur Acad Dermatol Venereol 2001 Mar;15(2):147-9. doi: 10.1046/j.1468-3083.2001.00213.x. PMID: 11495523

Diagnosis

(Reactive) Eccrine Syringofibroadenoma with Foci of Squamous Cell Carcinoma in situ: A Case Report.
Franin I, Regović Džombeta T, Krušlin B, Tomas D
Acta Dermatovenerol Croat 2021 Nov;29(4):224-227. PMID: 36896694
Eccrine syringofibroadenoma as a clue for the diagnosis of Schöpf-Schulz-Passarge syndrome in acquired palmoplantar keratoderma.
Riera-Monroig J, Martínez-Romero MDC, Alós L, Guillén-Navarro E, Mascaró JM Jr
J Cutan Pathol 2020 Oct;47(10):987-989. Epub 2020 Jun 1 doi: 10.1111/cup.13743. PMID: 32406069
Syringocystadenocarcinoma Papilliferum In Situ-Like Changes in Extramammary Paget Disease: A Report of 11 Cases.
Konstantinova AM, Kacerovska D, Stewart CJ, Szepe P, Pitha J, Sulc M, Bencik V, Michal M, Shideler B, Kerl K, Kazakov DV
Am J Dermatopathol 2016 Dec;38(12):882-886. doi: 10.1097/DAD.0000000000000554. PMID: 26863065
Immunohistochemical analysis of cytokeratin expression in reactive eccrine syringofibroadenoma-like lesion: a comparative study with eccrine syringofibroadenoma.
Ohnishi T, Watanabe S, Nomura K
J Cutan Pathol 2000 Apr;27(4):164-8. doi: 10.1034/j.1600-0560.2000.027004164.x. PMID: 10774936
Solitary eccrine syringofibroadenoma (or eccrine syringofibroadenomatous hyperplasia?) and diabetic polyneuropathy.
Gambini C, Rongioletti F, Semino MT, Rebora A
Dermatology 1996;193(1):68-9. doi: 10.1159/000246210. PMID: 8864629

Therapy

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Eccrine syringofibroadenoma-like change adjacent to a squamous cell carcinoma: potential histologic pitfall in Mohs micrographic surgery.
Duffy KL, Bowen AR, Tristani-Firouzi P, Florell SR, Hadley ML
Dermatol Surg 2009 Mar;35(3):519-22. doi: 10.1111/j.1524-4725.2009.01079.x. PMID: 19292840
Reactive eccrine syringofibroadenoma arising in peristomal skin: An unusual presentation of a rare lesion.
Mattoch IW, Pham N, Robbins JB, Bogomilsky J, Tandon M, Kohler S
J Am Acad Dermatol 2008 Apr;58(4):691-6. doi: 10.1016/j.jaad.2007.08.032. PMID: 18342718
Eccrine syringofibroadenoma arising in peristomal skin: a report of two cases.
Clarke LE, Ioffreda M, Abt AB
Int J Surg Pathol 2003 Jan;11(1):61-3. doi: 10.1177/106689690301100116. PMID: 12598924
A reactive acrosyringeal proliferation in a patient with ectodermal dysplasia: eccrine syringofibroadenoma-like lesion.
Utani A, Hattori Y
J Dermatol 1999 Jan;26(1):36-43. doi: 10.1111/j.1346-8138.1999.tb03507.x. PMID: 10063211

Prognosis

Multiple Eccrine Syringofibroadenoma of Mascaro of the Lower Extremity.
Lowell DL, Salvo NL, Weily WJ, Swiatek M, Sahli H
J Am Podiatr Med Assoc 2016 Nov;106(6):433-438. doi: 10.7547/15-066. PMID: 28033055
Syringocystadenocarcinoma Papilliferum In Situ-Like Changes in Extramammary Paget Disease: A Report of 11 Cases.
Konstantinova AM, Kacerovska D, Stewart CJ, Szepe P, Pitha J, Sulc M, Bencik V, Michal M, Shideler B, Kerl K, Kazakov DV
Am J Dermatopathol 2016 Dec;38(12):882-886. doi: 10.1097/DAD.0000000000000554. PMID: 26863065
Schöpf-Schulz-Passarge syndrome: further delineation of the phenotype and genetic considerations.
Castori M, Ruggieri S, Giannetti L, Annessi G, Zambruno G
Acta Derm Venereol 2008;88(6):607-12. doi: 10.2340/00015555-0547. PMID: 19002348
Leprosy-associated eccrine syringofibroadenoma of Mascaro.
Tey HL, Chong WS, Wong SN
Clin Exp Dermatol 2007 Sep;32(5):533-5. Epub 2007 Apr 24 doi: 10.1111/j.1365-2230.2007.02434.x. PMID: 17459067
Eccrine syringofibroadenoma: case report and review of the literature.
Takeda H, Mitsuhashi Y, Hayashi M, Kondo S
J Eur Acad Dermatol Venereol 2001 Mar;15(2):147-9. doi: 10.1046/j.1468-3083.2001.00213.x. PMID: 11495523

Clinical prediction guides

(Reactive) Eccrine Syringofibroadenoma with Foci of Squamous Cell Carcinoma in situ: A Case Report.
Franin I, Regović Džombeta T, Krušlin B, Tomas D
Acta Dermatovenerol Croat 2021 Nov;29(4):224-227. PMID: 36896694
Syringocystadenocarcinoma Papilliferum In Situ-Like Changes in Extramammary Paget Disease: A Report of 11 Cases.
Konstantinova AM, Kacerovska D, Stewart CJ, Szepe P, Pitha J, Sulc M, Bencik V, Michal M, Shideler B, Kerl K, Kazakov DV
Am J Dermatopathol 2016 Dec;38(12):882-886. doi: 10.1097/DAD.0000000000000554. PMID: 26863065
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?
Shalin SC, Rinaldi C, Horn TD
J Cutan Pathol 2013 Dec;40(12):1021-6. Epub 2013 Oct 10 doi: 10.1111/cup.12232. PMID: 24117902
Immunohistochemical analysis of cytokeratin expression in reactive eccrine syringofibroadenoma-like lesion: a comparative study with eccrine syringofibroadenoma.
Ohnishi T, Watanabe S, Nomura K
J Cutan Pathol 2000 Apr;27(4):164-8. doi: 10.1034/j.1600-0560.2000.027004164.x. PMID: 10774936
Filaggrin immunoreactive composite keratohyalin granules specific to acrosyringia and related tumours.
Ishida-Yamamoto A, Iizuka H, Eady RA
Acta Derm Venereol 1994 Jan;74(1):37-42. doi: 10.2340/00015555743742. PMID: 7511866

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