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Desmoplastic spitz nevus

MedGen UID:: 266159
•Concept ID:: C1275419
•: Neoplastic Process

Synonyms:	Desmoplastic spindle and epithelioid cell melanocytic nevus of skin; Desmoplastic spindle and epithelioid cell nevus; Desmoplastic Spitz Nevus; Desmoplastic Spitz nevus; desmoplastic spitz nevus; Desmoplastic spitz Nevus
SNOMED CT:	Desmoplastic Spitz nevus (400022009); Desmoplastic spindle and epithelioid cell melanocytic nevus of skin (400022009); Desmoplastic spindle and epithelioid cell nevus (400022009)

Monarch Initiative:	MONDO:0044800

Definition

A Spitz nevus associated with fibrous stroma formation. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDesmoplastic spitz nevus

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign neoplasm of skin
      - Benign melanocytic skin nevus
        Desmoplastic nevus
        Desmoplastic spitz nevus

Recent clinical studies

Etiology

MAP2K1-mutated melanocytic tumors have reproducible histopathologic features and share similarities with melanocytic tumors with BRAF V600E mutations.

Alomari AK, Harms PW, Andea AA, Warren SJ
J Cutan Pathol 2023 Dec;50(12):1083-1093. Epub 2023 Aug 11 doi: 10.1111/cup.14502. PMID: 37565534

Rosette-like structures in the spectrum of spitzoid tumors.

Arps DP, Harms PW, Chan MP, Fullen DR
J Cutan Pathol 2013 Sep;40(9):788-95. Epub 2013 Jun 29 doi: 10.1111/cup.12192. PMID: 23808731

The spectrum of Spitz nevi: a clinicopathologic study of 83 cases.

Ferrara G, Argenziano G, Soyer HP, Chimenti S, Di Blasi A, Pellacani G, Peris K, Piccolo D, Rubegni P, Seidenari S, Staibano S, Zalaudek I, De Rosa G
Arch Dermatol 2005 Nov;141(11):1381-7. doi: 10.1001/archderm.141.11.1381. PMID: 16301385

Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases.

Harvell JD, Bastian BC, LeBoit PE
Am J Surg Pathol 2002 May;26(5):654-61. doi: 10.1097/00000478-200205000-00012. PMID: 11979096

Angiomatoid Spitz nevus: a distinct variant of desmoplastic Spitz nevus with prominent vasculature.

Diaz-Cascajo C, Borghi S, Weyers W
Am J Dermatopathol 2000 Apr;22(2):135-9. doi: 10.1097/00000372-200004000-00008. PMID: 10770433

See all (7)

Diagnosis

MAP2K1-mutated melanocytic tumors have reproducible histopathologic features and share similarities with melanocytic tumors with BRAF V600E mutations.

Alomari AK, Harms PW, Andea AA, Warren SJ
J Cutan Pathol 2023 Dec;50(12):1083-1093. Epub 2023 Aug 11 doi: 10.1111/cup.14502. PMID: 37565534

Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.

Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201 Free PMC Article

What is your diagnosis? Desmoplastic Spitz nevus.

Tam CC, Hoover AZ, Elias AR
Cutis 2012 Jan;89(1):13, 22. PMID: 22439303

Angiomatoid Spitz nevus: a clinicopathological study of six cases and a review of the literature.

Tetzlaff MT, Xu X, Elder DE, Elenitsas R
J Cutan Pathol 2009 Apr;36(4):471-6. doi: 10.1111/j.1600-0560.2008.01060.x. PMID: 19278435

Desmoplastic spitz nevus: report of a case and review of the literature.

Dhouib RS, Sassi S, Jbeli A, Driss M, Mrad K, Abbes I, Ben Romdhane K
Pathologica 2008 Jun;100(3):181-4. PMID: 18841824

See all (10)

Prognosis

Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.

Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201 Free PMC Article

Angiomatoid Spitz nevus: a distinct variant of desmoplastic Spitz nevus with prominent vasculature.

Diaz-Cascajo C, Borghi S, Weyers W
Am J Dermatopathol 2000 Apr;22(2):135-9. doi: 10.1097/00000372-200004000-00008. PMID: 10770433

See all (2)

Clinical prediction guides

Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms.

Gerami P, Kim D, Compres EV, Zhang B, Khan AU, Sunshine JC, Quan VL, Busam K
Mod Pathol 2021 Feb;34(2):348-357. Epub 2020 Aug 29 doi: 10.1038/s41379-020-00658-w. PMID: 32862201 Free PMC Article

Desmoplastic spitz nevus: report of a case and review of the literature.

Dhouib RS, Sassi S, Jbeli A, Driss M, Mrad K, Abbes I, Ben Romdhane K
Pathologica 2008 Jun;100(3):181-4. PMID: 18841824

The spectrum of Spitz nevi: a clinicopathologic study of 83 cases.

See all (3)

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Desmoplastic spitz nevus

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Prognosis

Clinical prediction guides

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Reviews

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