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Ocular cicatricial pemphigoid(OCP)

MedGen UID:
266181
Concept ID:
C1282359
Disease or Syndrome
Synonyms: OCP; Ocular pemphigoid
SNOMED CT: OCP - Ocular cicatricial pemphigoid (314757003); Ocular cicatricial pemphigoid (314757003)
 
Monarch Initiative: MONDO:0008109
OMIM®: 164185

Definition

A chronic autoimmune disorder that belongs to the mucous membrane pemphigoid disorders. It is characterized by bilateral scarring and opacification of the conjunctivae. It presents with pain and burning sensation in the eyes and photophobia. It leads to blindness. [from NCI]

Clinical features

From HPO
Abnormality of the eye
MedGen UID:
1370071
Concept ID:
C4316870
Anatomical Abnormality
Any abnormality of the eye, including location, spacing, and intraocular abnormalities.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOcular cicatricial pemphigoid
Follow this link to review classifications for Ocular cicatricial pemphigoid in Orphanet.

Professional guidelines

PubMed

Wilson SE
J Ocul Pharmacol Ther 2023 Apr;39(3):191-206. Epub 2023 Mar 6 doi: 10.1089/jop.2022.0174. PMID: 36877777Free PMC Article
Sobolewska B, Deuter C, Zierhut M
Ocul Surf 2013 Oct;11(4):259-66. Epub 2013 Jul 9 doi: 10.1016/j.jtos.2013.02.003. PMID: 24112229
Chang JH, McCluskey PJ
Curr Allergy Asthma Rep 2005 Jul;5(4):333-8. doi: 10.1007/s11882-005-0078-9. PMID: 15967079

Recent clinical studies

Etiology

Çiftçi MD, Korkmaz İ, Palamar M, Yaman B, Eğrilmez S, Yağcı A, Akalın T, Barut Selver Ö
Turk J Ophthalmol 2023 Apr 20;53(2):79-84. doi: 10.4274/tjo.galenos.2022.34683. PMID: 37089009Free PMC Article
Philip AM, Stephenson A, Al-Dabbagh A, Ramezani K, Fernandez-Santos CC, Foster CS
Cornea 2023 Dec 1;42(12):1503-1505. Epub 2023 Jan 10 doi: 10.1097/ICO.0000000000003235. PMID: 36728301
Fremont F, Pelissier-Suarez C, Fournié P, Porterie M, Thevenin A, Astudillo L, Paricaud K, Gualino V, Soler V, Pugnet G
Cornea 2019 Nov;38(11):1406-1411. doi: 10.1097/ICO.0000000000002080. PMID: 31356420
Zierhut M, Stübiger N, Siepmann K, Deuter CM
Lupus 2005;14 Suppl 1:s50-4. doi: 10.1191/0961203305lu2119oa. PMID: 15803933
Francis IC, McCluskey PJ, Walls RS, Wakefield D, Brewer JM
Aust N Z J Ophthalmol 1990 May;18(2):143-50. doi: 10.1111/j.1442-9071.1990.tb00605.x. PMID: 2202335

Diagnosis

Stan C, Diaconu E, Hopirca L, Petra N, Rednic A, Stan C
Rom J Ophthalmol 2020 Apr-Jun;64(2):226-230. PMID: 32685792Free PMC Article
Wang K, Seitzman G, Gonzales JA
Curr Opin Ophthalmol 2018 Nov;29(6):543-551. doi: 10.1097/ICU.0000000000000517. PMID: 30222656
Hingorani M, Lightman S
Curr Opin Allergy Clin Immunol 2006 Oct;6(5):373-8. doi: 10.1097/01.all.0000244799.33734.d4. PMID: 16954792
Holsclaw DS
Int Ophthalmol Clin 1998 Fall;38(4):89-106. doi: 10.1097/00004397-199803840-00009. PMID: 10200078
Mondino BJ, Brown SI
Ophthalmology 1981 Feb;88(2):95-100. doi: 10.1016/s0161-6420(81)35069-6. PMID: 7015218

Therapy

Wang K, Seitzman G, Gonzales JA
Curr Opin Ophthalmol 2018 Nov;29(6):543-551. doi: 10.1097/ICU.0000000000000517. PMID: 30222656
Queisi MM, Zein M, Lamba N, Meese H, Foster CS
Surv Ophthalmol 2016 May-Jun;61(3):314-7. Epub 2015 Dec 19 doi: 10.1016/j.survophthal.2015.12.007. PMID: 26708362
Hingorani M, Lightman S
Curr Opin Allergy Clin Immunol 2006 Oct;6(5):373-8. doi: 10.1097/01.all.0000244799.33734.d4. PMID: 16954792
Chang JH, McCluskey PJ
Curr Allergy Asthma Rep 2005 Jul;5(4):333-8. doi: 10.1007/s11882-005-0078-9. PMID: 15967079
Holsclaw DS
Int Ophthalmol Clin 1998 Fall;38(4):89-106. doi: 10.1097/00004397-199803840-00009. PMID: 10200078

Prognosis

Hingorani M, Lightman S
Curr Opin Allergy Clin Immunol 2006 Oct;6(5):373-8. doi: 10.1097/01.all.0000244799.33734.d4. PMID: 16954792
Foster CS, Sainz De La Maza M
Curr Opin Allergy Clin Immunol 2004 Oct;4(5):435-9. doi: 10.1097/00130832-200410000-00017. PMID: 15349045
Khan B, Dudenhoefer EJ, Dohlman CH
Curr Opin Ophthalmol 2001 Aug;12(4):282-7. doi: 10.1097/00055735-200108000-00007. PMID: 11507341
Holsclaw DS
Int Ophthalmol Clin 1998 Fall;38(4):89-106. doi: 10.1097/00004397-199803840-00009. PMID: 10200078
Mondino BJ, Brown SI
Ophthalmology 1981 Feb;88(2):95-100. doi: 10.1016/s0161-6420(81)35069-6. PMID: 7015218

Clinical prediction guides

Jinagal J, Gupta B, Hanumanthu V, Chatterjee D, Limbu S, Malhotra C, Gupta A, Jain AK, Yangzes S, Mahajan R, Handa S, Pandav SS, De D
Cornea 2024 Aug 1;43(8):1015-1021. Epub 2024 Apr 26 doi: 10.1097/ICO.0000000000003547. PMID: 38692674
Ringer A, Smichowski AM, Gómez R, Virasoro B, Martínez L, Bertiller E, Siegrist C, Abdala B, Chulibert S, Grossi G, Rubín E, Kostianovsky A, Muñoz SA, Lutgen S, Gandino IJ; Study Working Group of Rheumatological Ocular Diseases, Argentinian Society of Rheumatology.
Int Ophthalmol 2024 Feb 20;44(1):99. doi: 10.1007/s10792-024-02939-8. PMID: 38376602
Çiftçi MD, Korkmaz İ, Palamar M, Yaman B, Eğrilmez S, Yağcı A, Akalın T, Barut Selver Ö
Turk J Ophthalmol 2023 Apr 20;53(2):79-84. doi: 10.4274/tjo.galenos.2022.34683. PMID: 37089009Free PMC Article
Smichowski AM, Caputo VD, Romeo C, Rivero E, Morales NS, Casado G
Reumatol Clin (Engl Ed) 2022 Jan;18(1):30-32. Epub 2021 Jun 2 doi: 10.1016/j.reumae.2020.10.003. PMID: 34088654
Wright P
Trans Ophthalmol Soc U K (1962) 1979 Apr;99(1):141-5. PMID: 398602

Recent systematic reviews

Bocanegra-Oyola N, Pardo-Pizza D, Cifuentes-González C, Oliver-Hernández MV, Romero-Osorio MJ, Romero-Santos S, Parra-Tanoux D, Barragán AM, de-la-Torre A
Ocul Immunol Inflamm 2024 Dec;32(10):2388-2404. Epub 2024 Jul 29 doi: 10.1080/09273948.2024.2376746. PMID: 39074301
Hingorani M, Lightman S
Curr Opin Allergy Clin Immunol 2006 Oct;6(5):373-8. doi: 10.1097/01.all.0000244799.33734.d4. PMID: 16954792

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