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Breast Inflammatory Myofibroblastic Tumor

MedGen UID:
267767
•Concept ID:
C1511315
•
Neoplastic Process

Definition

A multinodular intermediate fibroblastic neoplasm arising from the breast. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Inflammatory Myofibroblastic Tumor

Professional guidelines

PubMed

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response.
Kang K, Wu Y, Han C, Wang L, Wang Z, Zhao A
Comput Biol Med 2023 May;158:106836. Epub 2023 Mar 29 doi: 10.1016/j.compbiomed.2023.106836. PMID: 37031511
Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast.
Liu S, Yuan R, Jin Y, He C, Zheng X, Zhan Y
Breast J 2022;2022:1863123. Epub 2022 Aug 12 doi: 10.1155/2022/1863123. PMID: 36304484Free PMC Article
An inflammatory myofibroblastic tumour of the breast with ALK overexpression.
Zhou Y, Zhu J, Zhang Y, Jiang J, Jia M
BMJ Case Rep 2013 Feb 4;2013 doi: 10.1136/bcr-07-2011-4474. PMID: 23386486Free PMC Article
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824

Diagnosis

Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Mesenchymal tumors and tumor-like lesions of the breast: a contemporary approach review.
Stolnicu S, Moldovan C, Podoleanu C, Georgescu R
Ann Pathol 2015 Jan;35(1):15-31. Epub 2014 Dec 20 doi: 10.1016/j.annpat.2014.10.001. PMID: 25533916
IgG4-related disease.
Hirabayashi K, Zamboni G
Pathologica 2012 Apr;104(2):43-55. PMID: 22953500

Therapy

Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study.
Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z
Cancer Res Treat 2023 Jul;55(3):1001-1010. Epub 2023 Mar 3 doi: 10.4143/crt.2022.894. PMID: 36915248Free PMC Article
Impact of ALK Inhibitors in Patients With ALK-Rearranged Nonlung Solid Tumors.
Takeyasu Y, Okuma HS, Kojima Y, Nishikawa T, Tanioka M, Sudo K, Shimoi T, Noguchi E, Arakawa A, Mori T, Sunami K, Kubo T, Kohno T, Akihiko Y, Yamamoto N, Yonemori K
JCO Precis Oncol 2021;5 Epub 2021 May 3 doi: 10.1200/PO.20.00383. PMID: 34036223Free PMC Article
ALK-positive Histiocytosis of the Breast: A Clinicopathologic Study Highlighting Spindle Cell Histology.
Kashima J, Yoshida M, Jimbo K, Izutsu K, Ushiku T, Yonemori K, Yoshida A
Am J Surg Pathol 2021 Mar 1;45(3):347-355. doi: 10.1097/PAS.0000000000001567. PMID: 32826530
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824

Prognosis

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response.
Kang K, Wu Y, Han C, Wang L, Wang Z, Zhao A
Comput Biol Med 2023 May;158:106836. Epub 2023 Mar 29 doi: 10.1016/j.compbiomed.2023.106836. PMID: 37031511
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Mesenchymal tumors and tumor-like lesions of the breast: a contemporary approach review.
Stolnicu S, Moldovan C, Podoleanu C, Georgescu R
Ann Pathol 2015 Jan;35(1):15-31. Epub 2014 Dec 20 doi: 10.1016/j.annpat.2014.10.001. PMID: 25533916

Clinical prediction guides

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer.
Croizer H, Mhaidly R, Kieffer Y, Gentric G, Djerroudi L, Leclere R, Pelon F, Robley C, Bohec M, Meng A, Meseure D, Romano E, Baulande S, Peltier A, Vincent-Salomon A, Mechta-Grigoriou F
Nat Commun 2024 Apr 1;15(1):2806. doi: 10.1038/s41467-024-47068-z. PMID: 38561380Free PMC Article
Homologous recombination deficiency in triple-negative breast cancer: Multi-scale transcriptomics reveals distinct tumor microenvironments and limitations in predicting immunotherapy response.
Kang K, Wu Y, Han C, Wang L, Wang Z, Zhao A
Comput Biol Med 2023 May;158:106836. Epub 2023 Mar 29 doi: 10.1016/j.compbiomed.2023.106836. PMID: 37031511
TRK Fusion Cancers in Children: A Clinical Review and Recommendations for Screening.
Albert CM, Davis JL, Federman N, Casanova M, Laetsch TW
J Clin Oncol 2019 Feb 20;37(6):513-524. Epub 2018 Dec 28 doi: 10.1200/JCO.18.00573. PMID: 30592640
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor of the Spleen: Case Report and Review of the Literature.
Kitamura Y, Takayama Y, Nishie A, Asayama Y, Ushijima Y, Fujita N, Morita K, Baba S, Kubo Y, Shirabe K, Honda H
Magn Reson Med Sci 2015;14(4):347-54. Epub 2015 Feb 12 doi: 10.2463/mrms.2014-0052. PMID: 25740238

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