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Bluetongue

MedGen UID:
2687
•Concept ID:
C0005866
•
Disease or Syndrome
Synonyms: Blue Tongue; Tongue, Blue

Definition

A reovirus infection, chiefly of sheep, characterized by a swollen blue tongue, catarrhal inflammation of upper respiratory and gastrointestinal tracts, and often by inflammation of sensitive laminae of the feet and coronet. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBluetongue

Professional guidelines

PubMed

Bluetongue disease risk assessment based on observed and projected Culicoides obsoletus spp. vector densities.
Brugger K, Rubel F
PLoS One 2013;8(4):e60330. Epub 2013 Apr 1 doi: 10.1371/journal.pone.0060330. PMID: 23560090Free PMC Article

Recent clinical studies

Etiology

BTV risk prompts farmers to store embryos.
Loeb J
Vet Rec 2024 Jul 6;195(1):9. doi: 10.1002/vetr.4444. PMID: 38967185
Bluetongue Virus Particles as Nanoreactors for Enzyme Delivery and Cancer Therapy.
Thuenemann EC, Le DHT, Lomonossoff GP, Steinmetz NF
Mol Pharm 2021 Mar 1;18(3):1150-1156. Epub 2021 Feb 10 doi: 10.1021/acs.molpharmaceut.0c01053. PMID: 33566625Free PMC Article
RECENT CHANGES IN INFECTIOUS DISEASES IN EUROPEAN WILDLIFE.
Yon L, Duff JP, Ågren EO, Erdélyi K, Ferroglio E, Godfroid J, Hars J, Hestvik G, Horton D, Kuiken T, Lavazza A, Markowska-Daniel I, Martel A, Neimanis A, Pasmans F, Price SJ, Ruiz-Fons F, Ryser-Degiorgis MP, Widén F, Gavier-Widén D
J Wildl Dis 2019 Jan;55(1):3-43. Epub 2018 Oct 4 doi: 10.7589/2017-07-172. PMID: 30284963
Present and future arboviral threats.
Weaver SC, Reisen WK
Antiviral Res 2010 Feb;85(2):328-45. Epub 2009 Oct 24 doi: 10.1016/j.antiviral.2009.10.008. PMID: 19857523Free PMC Article
Potential arbovirus emergence and implications for the United Kingdom.
Gould EA, Higgs S, Buckley A, Gritsun TS
Emerg Infect Dis 2006 Apr;12(4):549-55. doi: 10.3201/eid1204.051010. PMID: 16704800Free PMC Article

Diagnosis

Zoonotic risks from small ruminants.
Ganter M
Vet Microbiol 2015 Dec 14;181(1-2):53-65. Epub 2015 Jul 15 doi: 10.1016/j.vetmic.2015.07.015. PMID: 26275853
Orbiviruses: A North American Perspective.
McVey DS, Drolet BS, Ruder MG, Wilson WC, Nayduch D, Pfannenstiel R, Cohnstaedt LW, MacLachlan NJ, Gay CG
Vector Borne Zoonotic Dis 2015 Jun;15(6):335-8. doi: 10.1089/vbz.2014.1699. PMID: 26086554
Orbiviruses: A Gap Analysis.
Gay CG
Vector Borne Zoonotic Dis 2015 Jun;15(6):333-4. doi: 10.1089/vbz.2015.28999.cgg. PMID: 26086553
Evidence-based early clinical detection of emerging diseases in food animals and zoonoses: two cases.
Saegerman C, Humblet MF, Porter SR, Zanella G, Martinelle L
Vet Clin North Am Food Anim Pract 2012 Mar;28(1):121-31, x. doi: 10.1016/j.cvfa.2012.01.001. PMID: 22374122
Genetically engineered particulate virus-like structures and their use as vaccine delivery systems.
Roy P
Intervirology 1996;39(1-2):62-71. doi: 10.1159/000150476. PMID: 8957671

Therapy

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.
Mohd Jaafar F, Monsion B, Belhouchet M, Mertens PPC, Attoui H
Viruses 2021 Jul 23;13(8) doi: 10.3390/v13081437. PMID: 34452303Free PMC Article
Bluetongue Virus Particles as Nanoreactors for Enzyme Delivery and Cancer Therapy.
Thuenemann EC, Le DHT, Lomonossoff GP, Steinmetz NF
Mol Pharm 2021 Mar 1;18(3):1150-1156. Epub 2021 Feb 10 doi: 10.1021/acs.molpharmaceut.0c01053. PMID: 33566625Free PMC Article
Meeting report VLPNPV: Session 5: Plant based technology.
Meador LR, Mor TS
Hum Vaccin Immunother 2014;10(10):3068-73. doi: 10.4161/21645515.2014.979693. PMID: 25581535Free PMC Article
The influence of the wind in the Schmallenberg virus outbreak in Europe.
Sedda L, Rogers DJ
Sci Rep 2013 Nov 28;3:3361. doi: 10.1038/srep03361. PMID: 24285292Free PMC Article
Developing country applications of molecular farming: case studies in South Africa and Argentina.
Rybicki EP, Hitzeroth II, Meyers A, Dus Santos MJ, Wigdorovitz A
Curr Pharm Des 2013;19(31):5612-21. doi: 10.2174/1381612811319310015. PMID: 23394557

Prognosis

Monitoring longitudinal immunological responses to bluetongue virus 17 in experimentally infected sheep.
Westrich JA, McNulty EE, Carpenter M, Burton M, Reed K, Nalls A, Sandoval A, Mayo C, Mathiason CK
Virus Res 2023 Dec;338:199246. Epub 2023 Oct 19 doi: 10.1016/j.virusres.2023.199246. PMID: 37858729Free PMC Article
The current status of phlebotomine sand flies in Albania and incrimination of Phlebotomus neglectus (Diptera, Psychodidae) as the main vector of Leishmania infantum.
Velo E, Bongiorno G, Kadriaj P, Myrseli T, Crilly J, Lika A, Mersini K, Di Muccio T, Bino S, Gramiccia M, Gradoni L, Maroli M
PLoS One 2017;12(6):e0179118. Epub 2017 Jun 19 doi: 10.1371/journal.pone.0179118. PMID: 28628627Free PMC Article
The Interaction between Vector Life History and Short Vector Life in Vector-Borne Disease Transmission and Control.
Brand SP, Rock KS, Keeling MJ
PLoS Comput Biol 2016 Apr;12(4):e1004837. Epub 2016 Apr 29 doi: 10.1371/journal.pcbi.1004837. PMID: 27128163Free PMC Article
The arrival, establishment and spread of exotic diseases: patterns and predictions.
Randolph SE, Rogers DJ
Nat Rev Microbiol 2010 May;8(5):361-71. Epub 2010 Apr 7 doi: 10.1038/nrmicro2336. PMID: 20372156
Potential arbovirus emergence and implications for the United Kingdom.
Gould EA, Higgs S, Buckley A, Gritsun TS
Emerg Infect Dis 2006 Apr;12(4):549-55. doi: 10.3201/eid1204.051010. PMID: 16704800Free PMC Article

Clinical prediction guides

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.
Mohd Jaafar F, Monsion B, Belhouchet M, Mertens PPC, Attoui H
Viruses 2021 Jul 23;13(8) doi: 10.3390/v13081437. PMID: 34452303Free PMC Article
How much can diptera-borne viruses persist over unfavourable seasons?
Charron MV, Balenghien T, Seegers H, Langlais M, Ezanno P
PLoS One 2013;8(9):e74213. Epub 2013 Sep 4 doi: 10.1371/journal.pone.0074213. PMID: 24023929Free PMC Article
Evidence-based early clinical detection of emerging diseases in food animals and zoonoses: two cases.
Saegerman C, Humblet MF, Porter SR, Zanella G, Martinelle L
Vet Clin North Am Food Anim Pract 2012 Mar;28(1):121-31, x. doi: 10.1016/j.cvfa.2012.01.001. PMID: 22374122
Potential arbovirus emergence and implications for the United Kingdom.
Gould EA, Higgs S, Buckley A, Gritsun TS
Emerg Infect Dis 2006 Apr;12(4):549-55. doi: 10.3201/eid1204.051010. PMID: 16704800Free PMC Article
A rapid indirect ELISA for the serogrouping of Australian orbiviruses.
Blacksell SD, Lunt RA, White JR
J Virol Methods 1994 Aug;49(1):67-78. doi: 10.1016/0166-0934(94)90056-6. PMID: 7829593

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