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Conventional Ameloblastoma

MedGen UID:
271208
•Concept ID:
C1513734
•
Neoplastic Process
Synonyms: Intraosseous Ameloblastoma; Solid/Multicystic Ameloblastoma

Definition

An intraosseous ameloblastoma that arises from the jaw, usually the mandible. It grows slowly, invades locally, and recurs frequently. It presents with swelling of the jaw. [from NCI]

Professional guidelines

PubMed

Conservative Versus Radical Treatment of Ameloblastoma: A 14-Year Study in Kedah, Malaysia.
Ling XF, Ismail SB, Zainal Abidin MB, Bt Amran NA, Bin Abd Samad MA, Tew MM, Awang Hasyim NB
J Craniofac Surg 2025 Jan-Feb 01;36(1):186-190. Epub 2024 Sep 25 doi: 10.1097/SCS.0000000000010690. PMID: 39320099
Histopathologic and Molecular Insights Following the Management of Ameloblastomas via Targeted Therapies - Pathological and Clinical Perspectives.
Hirschhorn A, Grynberg S, Campino GA, Dobriyan A, Patel V, Greenberg G, Yacobi R, Barshack I, Yahalom R, Toren A, Vered M
Head Neck Pathol 2024 Dec 2;18(1):129. doi: 10.1007/s12105-024-01734-2. PMID: 39621130Free PMC Article
Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years.
Leite-Lima F, Martins-Chaves RR, de Castro WH, Gomez RS
Oral Maxillofac Surg 2024 Nov 4;29(1):4. doi: 10.1007/s10006-024-01296-1. PMID: 39495234

Recent clinical studies

Etiology

Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years.
Leite-Lima F, Martins-Chaves RR, de Castro WH, Gomez RS
Oral Maxillofac Surg 2024 Nov 4;29(1):4. doi: 10.1007/s10006-024-01296-1. PMID: 39495234
Differential expression of PEA3 in odontogenic cysts and tumors.
Tun KM, Kitkumthorn N, Bumalee D, Arayapisit T, Lapthanasupkul P
J Oral Pathol Med 2023 Sep;52(8):777-785. Epub 2023 Aug 7 doi: 10.1111/jop.13476. PMID: 37549030
Recurrent tumors of ameloblastoma: Clinicopathologic features and diagnostic outcome.
Nwoga MC
Niger J Clin Pract 2022 Oct;25(10):1771-1777. doi: 10.4103/njcp.njcp_82_22. PMID: 36308255
Recurrent tumours of ameloblastoma: Clinicopathologic features and diagnostic outcome.
Nwoga MC
Niger J Clin Pract 2022 Sep;25(9):1529-1534. doi: 10.4103/njcp.njcp_82_22. PMID: 36149215
Immunoexpression of BRAF, EGFR and CD10 in ameloblastoma.
Tan CC, Siar CH, Shanmuhasuntharam P
Malays J Pathol 2022 Apr;44(1):19-28. PMID: 35484883

Diagnosis

Papilliferous Keratoameloblastoma: Systematic review.
Sachdev SS, Chettiankandy TJ, Adhane YB, Sardar MA, Trimukhe A, Jain R
Sultan Qaboos Univ Med J 2023 Aug;23(3):288-296. Epub 2023 Aug 28 doi: 10.18295/squmj.5.2023.021. PMID: 37655071Free PMC Article
Recurrent tumors of ameloblastoma: Clinicopathologic features and diagnostic outcome.
Nwoga MC
Niger J Clin Pract 2022 Oct;25(10):1771-1777. doi: 10.4103/njcp.njcp_82_22. PMID: 36308255
Recurrent tumours of ameloblastoma: Clinicopathologic features and diagnostic outcome.
Nwoga MC
Niger J Clin Pract 2022 Sep;25(9):1529-1534. doi: 10.4103/njcp.njcp_82_22. PMID: 36149215
Adenoid ameloblastoma harbors beta-catenin mutations.
Bastos VC, Coura BP, Guimarães LM, Fernandes BG, Chan AC, Vargas PA, Bastos-Rodrigues L, De Marco LA, Hellstein J, Thavaraj S, Wright JM, Odell EW, Gomez RS, Gomes CC
Mod Pathol 2022 Nov;35(11):1562-1569. Epub 2022 Jul 15 doi: 10.1038/s41379-022-01125-4. PMID: 35840721
Oral and maxillofacial pathology case of the month. Conventional ameloblastoma-granular cell type.
Awagu SC, Vigneswaran N
Tex Dent J 2004 Nov;121(11):1084, 1090-1. PMID: 15643781

Therapy

Ameloblastoma in young persons: a clinicopathologic analysis and etiologic investigation.
Kahn MA
Oral Surg Oral Med Oral Pathol 1989 Jun;67(6):706-15. doi: 10.1016/0030-4220(89)90013-3. PMID: 2544844

Prognosis

Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years.
Leite-Lima F, Martins-Chaves RR, de Castro WH, Gomez RS
Oral Maxillofac Surg 2024 Nov 4;29(1):4. doi: 10.1007/s10006-024-01296-1. PMID: 39495234
Perilipin 1 and adipophilin immunoexpression suggests the presence of lipid droplets in tooth germ, ameloblastoma, and ameloblastic carcinoma.
Sánchez-Romero C, Carreón-Burciaga R, Gónzalez-Gónzalez R, Villarroel-Dorrego M, Molina-Frechero N, Bologna-Molina R
J Oral Pathol Med 2021 Aug;50(7):708-715. Epub 2021 Apr 20 doi: 10.1111/jop.13175. PMID: 33733498
The Mutational Profile of Unicystic Ameloblastoma.
Heikinheimo K, Huhtala JM, Thiel A, Kurppa KJ, Heikinheimo H, Kovac M, Kragelund C, Warfvinge G, Dawson H, Elenius K, Ristimäki A, Baumhoer D, Morgan PR
J Dent Res 2019 Jan;98(1):54-60. Epub 2018 Sep 14 doi: 10.1177/0022034518798810. PMID: 30216733
Comparative Study of the Minichromosome Maintenance Proteins Complex (MCM 4/5/6) in Ameloblastoma and Unicystic Ameloblastoma.
Apellániz D, Pereira-Prado V, Sicco E, Vigil-Bastitta G, González-González R, Mosqueda-Taylor A, Molina-Frechero N, Hernandez M, Sánchez-Romero C, Bologna-Molina R
Int J Surg Pathol 2018 Dec;26(8):714-720. Epub 2018 May 30 doi: 10.1177/1066896918778341. PMID: 29845895
Immunohistochemical detection of p53 protein in ameloblastoma types.
el-Sissy NA
East Mediterr Health J 1999 May;5(3):478-89. PMID: 10793827

Clinical prediction guides

Surgical management of conventional ameloblastoma: a retrospective cohort study over the past 21 years.
Leite-Lima F, Martins-Chaves RR, de Castro WH, Gomez RS
Oral Maxillofac Surg 2024 Nov 4;29(1):4. doi: 10.1007/s10006-024-01296-1. PMID: 39495234
LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma.
Correa-Arzate L, Portilla-Robertson J, Ramírez-Jarquín JO, Jacinto-Alemán LF, Mejía-Velázquez CP, Villanueva-Sánchez FG, Rodríguez-Vázquez M
Genes (Basel) 2023 Jul 26;14(8) doi: 10.3390/genes14081524. PMID: 37628576Free PMC Article
Differential expression of PEA3 in odontogenic cysts and tumors.
Tun KM, Kitkumthorn N, Bumalee D, Arayapisit T, Lapthanasupkul P
J Oral Pathol Med 2023 Sep;52(8):777-785. Epub 2023 Aug 7 doi: 10.1111/jop.13476. PMID: 37549030
Recurrent tumours of ameloblastoma: Clinicopathologic features and diagnostic outcome.
Nwoga MC
Niger J Clin Pract 2022 Sep;25(9):1529-1534. doi: 10.4103/njcp.njcp_82_22. PMID: 36149215
Adenoid ameloblastoma harbors beta-catenin mutations.
Bastos VC, Coura BP, Guimarães LM, Fernandes BG, Chan AC, Vargas PA, Bastos-Rodrigues L, De Marco LA, Hellstein J, Thavaraj S, Wright JM, Odell EW, Gomez RS, Gomes CC
Mod Pathol 2022 Nov;35(11):1562-1569. Epub 2022 Jul 15 doi: 10.1038/s41379-022-01125-4. PMID: 35840721

Recent systematic reviews

Papilliferous Keratoameloblastoma: Systematic review.
Sachdev SS, Chettiankandy TJ, Adhane YB, Sardar MA, Trimukhe A, Jain R
Sultan Qaboos Univ Med J 2023 Aug;23(3):288-296. Epub 2023 Aug 28 doi: 10.18295/squmj.5.2023.021. PMID: 37655071Free PMC Article

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