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Malignant testicular Leydig cell tumor

MedGen UID:: 271769
•Concept ID:: C1515288
•: Neoplastic Process

Synonyms:	Malignant Testicular Leydig Cell Tumor; malignant testicular Leydig cell tumor; testicular Leydig cell tumor, malignant

Monarch Initiative:	MONDO:0003737

Definition

A Leydig cell tumor characterized by a large size, cellular atypia, high mitotic activity, vascular invasion and necrotic changes. The prognosis is usually poor. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant testicular Leydig cell tumor

Adnexal Diseases
- Disorder of ovary
  - Ovarian neoplasm
    - Sertoli-Leydig cell tumor
      - Leydig cell tumor
        Malignant Leydig cell tumor
        Malignant testicular Leydig cell tumor

Professional guidelines

PubMed

Testicular adrenal rest tumors - Epidemiology, diagnosis and treatment.

Eyer de Jesus L, Paz de Oliveira AP, Porto LC, Dekermacher S
J Pediatr Urol 2024 Feb;20(1):77-87. Epub 2023 Oct 7 doi: 10.1016/j.jpurol.2023.10.005. PMID: 37845103

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841

Gynaecomastia--pathophysiology, diagnosis and treatment.

Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235

See all (20)

Recent clinical studies

Etiology

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Androgen-Secreting Ovarian Tumors.

Macut D, Ilić D, Mitrović Jovanović A, Bjekić-Macut J
Front Horm Res 2019;53:100-107. Epub 2019 Sep 9 doi: 10.1159/000494906. PMID: 31499493

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA
Clin Cancer Res 2018 May 15;24(10):2251-2261. Epub 2018 Jan 17 doi: 10.1158/1078-0432.CCR-17-3089. PMID: 29343557 Free PMC Article

Testicular tumors other than germ cell tumors.

Young RH, Talerman A
Semin Diagn Pathol 1987 Nov;4(4):342-60. PMID: 2832918

See all (195)

Diagnosis

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Gynaecomastia--pathophysiology, diagnosis and treatment.

Narula HS, Carlson HE
Nat Rev Endocrinol 2014 Nov;10(11):684-98. Epub 2014 Aug 12 doi: 10.1038/nrendo.2014.139. PMID: 25112235

Testicular tumours.

Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

Testicular tumors.

Markland C
Curr Probl Surg 1968 Sep:3-51. doi: 10.1016/s0011-3840(68)80001-2. PMID: 4386486

See all (368)

Therapy

Cryptorchidism --disease or symptom?

Toppari J, Rodprasert W, Virtanen HE
Ann Endocrinol (Paris) 2014 May;75(2):72-6. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.010. PMID: 24786701

Contrast-enhanced ultrasonographic (CEUS) and elastosonographic features of a case of testicular Leydig tumor.

Cantisani V, Olive M, Di Segni M, Di Leo N, Grazdhani H, D'Ettorre G, Ceccarelli G, Fioravanti C, Ricci P
Ultraschall Med 2012 Oct;33(5):409-410. doi: 10.1055/s-0031-1299430. PMID: 22623134

High frequency of metastatic Leydig cell testicular tumours.

Farkas LM, Székely JG, Pusztai C, Baki M
Oncology 2000 Aug;59(2):118-21. doi: 10.1159/000012147. PMID: 10971169

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Testicular tumours.

Peckham MJ, McElwain TJ
Clin Endocrinol Metab 1975 Nov;4(3):665-92. doi: 10.1016/s0300-595x(75)80052-1. PMID: 58746

See all (83)

Prognosis

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Leydig cell hyperplasia in children: Case series and review.

Mennie N, King SK, Marulaiah M, Ferguson P, Heloury Y, Kimber C
J Pediatr Urol 2017 Apr;13(2):158-163. Epub 2017 Feb 10 doi: 10.1016/j.jpurol.2016.12.028. PMID: 28238607

Leydig cell tumor of the testis.

Jou P, Maclennan GT
J Urol 2009 May;181(5):2299-300. Epub 2009 Mar 19 doi: 10.1016/j.juro.2009.02.051. PMID: 19303105

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

INTERSTITIAL-CELL TUMOUR.

COLLINS DH, CAMERON KM
Br J Urol 1964 Jun;36:SUPPL:62-9. PMID: 14184711

See all (161)

Clinical prediction guides

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.

Ovarian Sex Cord-Stromal Tumors.

Schultz KA, Harris AK, Schneider DT, Young RH, Brown J, Gershenson DM, Dehner LP, Hill DA, Messinger YH, Frazier AL
J Oncol Pract 2016 Oct;12(10):940-946. doi: 10.1200/JOP.2016.016261. PMID: 27858560 Free PMC Article

Testicular and testicular adnexa tumors in the elderly.

Gigantino V, La Mantia E, Franco R, Cecere S, Rossetti S, Di Napoli M, Pisano C, Berretta M, Galzerano A, Botti G, Pignata S, Facchini G
Anticancer Drugs 2013 Mar;24(3):228-36. doi: 10.1097/CAD.0b013e32835a3598. PMID: 23059385

The toxicology of perfluorooctanoate.

Kennedy GL Jr, Butenhoff JL, Olsen GW, O'Connor JC, Seacat AM, Perkins RG, Biegel LB, Murphy SR, Farrar DG
Crit Rev Toxicol 2004 Jul-Aug;34(4):351-84. doi: 10.1080/10408440490464705. PMID: 15328768

High frequency of metastatic Leydig cell testicular tumours.

Farkas LM, Székely JG, Pusztai C, Baki M
Oncology 2000 Aug;59(2):118-21. doi: 10.1159/000012147. PMID: 10971169

See all (171)

Recent systematic reviews

Testis-sparing surgery in children with testicular tumors: A systematic review and meta-analysis.

Miao X, Li Y, Zhou T, Lv M
Asian J Surg 2021 Dec;44(12):1503-1509. Epub 2021 Apr 21 doi: 10.1016/j.asjsur.2021.03.016. PMID: 33893031

Testis-sparing surgery for testicular tumors in children: a 20 year single center experience and systematic review of the literature.

Bois JI, Vagni RL, de Badiola FI, Moldes JM, Losty PD, Lobos PA
Pediatr Surg Int 2021 May;37(5):607-616. Epub 2021 Jan 17 doi: 10.1007/s00383-020-04850-6. PMID: 33454815

Treatment of leydig cell tumours of the testis: Can testis-sparing surgery replace radical orchidectomy? Results of a systematic review.

Bozzini G, Ratti D, Carmignani L; en representación de Young Academic Urologists (YAU) Men's Health Group
Actas Urol Esp 2017 Apr;41(3):146-154. Epub 2016 Nov 25 doi: 10.1016/j.acuro.2016.04.014. PMID: 27890492

See all (3)

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Malignant testicular Leydig cell tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

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Clinical resources

Practice guidelines

Consumer resources

Reviews

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