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Deletion of Chromosome 22 Associated Meningioma

MedGen UID:
272539
•Concept ID:
C1333269
•
Neoplastic Process

Definition

A meningioma that is associated with deletion of chromosome 22. This abnormality is the most consistent cytogenetic finding that is detected in meningiomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeletion of Chromosome 22 Associated Meningioma

Professional guidelines

PubMed

Neurofibromatosis type 2 (NF2): diagnosis and management.
Lloyd SK, Evans DG
Handb Clin Neurol 2013;115:957-67. doi: 10.1016/B978-0-444-52902-2.00054-0. PMID: 23931824

Recent clinical studies

Etiology

Meningioma in Down Syndrome.
Yamamoto T, Shinojima N, Todaka T, Nishikawa S, Yano S, Kuratsu J
World Neurosurg 2015 Sep;84(3):866.e1-6. Epub 2015 Apr 9 doi: 10.1016/j.wneu.2015.03.065. PMID: 25862935
Radiation-associated meningiomas in children: clinical, pathological, and cytogenetic characteristics with a critical review of the literature.
Elbabaa SK, Gokden M, Crawford JR, Kesari S, Saad AG
J Neurosurg Pediatr 2012 Oct;10(4):281-90. Epub 2012 Aug 17 doi: 10.3171/2012.7.PEDS1251. PMID: 22900483
Pathology and genetics of meningiomas.
Alahmadi H, Croul SE
Semin Diagn Pathol 2011 Nov;28(4):314-24. doi: 10.1053/j.semdp.2011.01.002. PMID: 22195409
Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings.
Al-Mefty O, Kadri PA, Pravdenkova S, Sawyer JR, Stangeby C, Husain M
J Neurosurg 2004 Aug;101(2):210-8. doi: 10.3171/jns.2004.101.2.0210. PMID: 15309910
Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome-specific probes.
Sayagués JM, Tabernero MD, Maillo A, Díaz P, Rasillo A, Bortoluci A, Gomez-Moreta J, Santos-Briz A, Morales F, Orfao A
Cytometry 2002 Jun 15;50(3):153-9. doi: 10.1002/cyto.10075. PMID: 12116338

Diagnosis

Meningioma in Down Syndrome.
Yamamoto T, Shinojima N, Todaka T, Nishikawa S, Yano S, Kuratsu J
World Neurosurg 2015 Sep;84(3):866.e1-6. Epub 2015 Apr 9 doi: 10.1016/j.wneu.2015.03.065. PMID: 25862935
Neurofibromatosis type 2 (NF2): diagnosis and management.
Lloyd SK, Evans DG
Handb Clin Neurol 2013;115:957-67. doi: 10.1016/B978-0-444-52902-2.00054-0. PMID: 23931824
Neurofibromatosis type 2.
Evans GR, Lloyd SKW, Ramsden RT
Adv Otorhinolaryngol 2011;70:91-98. Epub 2011 Feb 24 doi: 10.1159/000322482. PMID: 21358190
Deletion of chromosome 1p and loss of expression of alkaline phosphatase indicate progression of meningiomas.
Müller P, Henn W, Niedermayer I, Ketter R, Feiden W, Steudel WI, Zang KD, Steilen-Gimbel H
Clin Cancer Res 1999 Nov;5(11):3569-77. PMID: 10589773
Meningiomas.
Black PM
Neurosurgery 1993 Apr;32(4):643-57. doi: 10.1227/00006123-199304000-00023. PMID: 8474655

Therapy

Correspondence of tumor localization with tumor recurrence and cytogenetic progression in meningiomas.
Ketter R, Rahnenführer J, Henn W, Kim YJ, Feiden W, Steudel WI, Zang KD, Urbschat S
Neurosurgery 2008 Jan;62(1):61-9; discussion 69-70. doi: 10.1227/01.NEU.0000311062.72626.D6. PMID: 18300892
Cytogenetics and molecular genetics of nervous system tumors.
Rey JA, Pestaña A, Bello MJ
Oncol Res 1992;4(8-9):321-31. PMID: 1336685

Prognosis

Association between inflammatory infiltrates and isolated monosomy 22/del(22q) in meningiomas.
Domingues PH, Teodósio C, Otero Á, Sousa P, Ortiz J, Macias Mdel C, Gonçalves JM, Nieto AB, Lopes MC, de Oliveira C, Orfao A, Tabernero MD
PLoS One 2013;8(10):e74798. Epub 2013 Oct 1 doi: 10.1371/journal.pone.0074798. PMID: 24098347Free PMC Article
Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings.
Al-Mefty O, Kadri PA, Pravdenkova S, Sawyer JR, Stangeby C, Husain M
J Neurosurg 2004 Aug;101(2):210-8. doi: 10.3171/jns.2004.101.2.0210. PMID: 15309910
Incidence of numerical chromosome aberrations in meningioma tumors as revealed by fluorescence in situ hybridization using 10 chromosome-specific probes.
Sayagués JM, Tabernero MD, Maillo A, Díaz P, Rasillo A, Bortoluci A, Gomez-Moreta J, Santos-Briz A, Morales F, Orfao A
Cytometry 2002 Jun 15;50(3):153-9. doi: 10.1002/cyto.10075. PMID: 12116338
Deletion of chromosome 1p and loss of expression of alkaline phosphatase indicate progression of meningiomas.
Müller P, Henn W, Niedermayer I, Ketter R, Feiden W, Steudel WI, Zang KD, Steilen-Gimbel H
Clin Cancer Res 1999 Nov;5(11):3569-77. PMID: 10589773
Meningiomas.
Black PM
Neurosurgery 1993 Apr;32(4):643-57. doi: 10.1227/00006123-199304000-00023. PMID: 8474655

Clinical prediction guides

Association between mutation of the NF2 gene and monosomy 22 in menopausal women with sporadic meningiomas.
Tabernero M, Jara-Acevedo M, Nieto AB, Caballero AR, Otero A, Sousa P, Gonçalves J, Domingues PH, Orfao A
BMC Med Genet 2013 Oct 30;14:114. doi: 10.1186/1471-2350-14-114. PMID: 24171707Free PMC Article
Molecular genetics of meningiomas.
Ragel BT, Jensen RL
Neurosurg Focus 2005 Nov 15;19(5):E9. doi: 10.3171/foc.2005.19.5.10. PMID: 16398473
Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region.
Zucman-Rossi J, Legoix P, Thomas G
Genomics 1996 Dec 15;38(3):247-54. doi: 10.1006/geno.1996.0625. PMID: 8975699
Meningiomas.
Black PM
Neurosurgery 1993 Apr;32(4):643-57. doi: 10.1227/00006123-199304000-00023. PMID: 8474655
Loss of heterozygosity on the long arm of chromosome 22 in pheochromocytoma.
Tanaka N, Nishisho I, Yamamoto M, Miya A, Shin E, Karakawa K, Fujita S, Kobayashi T, Rouleau GA, Mori T
Genes Chromosomes Cancer 1992 Nov;5(4):399-403. doi: 10.1002/gcc.2870050416. PMID: 1283329

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