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Testicular trophoblastic tumor

MedGen UID:
272844
•Concept ID:
C1515301
•
Neoplastic Process
Synonyms: Testicular Trophoblastic Tumor; testicular trophoblastic tumor
 
Monarch Initiative: MONDO:0002871

Definition

A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. The vast majority of cases are choriocarcinomas. [from NCI]

Professional guidelines

PubMed

Trophoblastic disease: natural history, diagnosis, and treatment.
Li MC
Ann Intern Med 1971 Jan;74(1):102-12. doi: 10.7326/0003-4819-74-1-102. PMID: 4321708
The place of chemotherapy in the treatment of testicular tumors.
Golbey RB
JAMA 1970 Jul 6;213(1):101-3 passim. PMID: 5467953
Management of choriocarcinoma and related tumors of uterus and testis.
LI MC
Med Clin North Am 1961 May;45:661-76. doi: 10.1016/s0025-7125(16)33879-2. PMID: 13761821

Recent clinical studies

Etiology

Hemorrhage: a complication of metastatic testicular choriocarcinoma.
Motzer RJ, Bosl GJ
Urology 1987 Aug;30(2):119-22. doi: 10.1016/0090-4295(87)90175-0. PMID: 3617293
Curative cancer chemotherapy.
Frei E 3rd
Cancer Res 1985 Dec;45(12 Pt 1):6523-37. PMID: 2998603
Bleomycin in testicular teratomas.
Brunner KW, Sonntag RW
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1975 Nov 25;84(3):291-7. doi: 10.1007/BF00312250. PMID: 53948
Malignant testicular tumours.
Del Vecchio P, Tawil E, Béland G
Can Med Assoc J 1974 Jan 19;110(2):159-62. PMID: 4855670Free PMC Article
Proceedings: Testicular tumors. Epidemiologic, etiologic, and pathologic features.
Mostofi FK
Cancer 1973 Nov;32(5):1186-201. doi: 10.1002/1097-0142(197311)32:5<1186::aid-cncr2820320527>3.0.co;2-8. PMID: 4148412

Diagnosis

Ten testicular trapdoors.
Rajab R, Berney DM
Histopathology 2008 Dec;53(6):728-39. Epub 2008 Mar 12 doi: 10.1111/j.1365-2559.2008.03001.x. PMID: 18336561
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Scrotal ultrasound.
Krone KD, Carroll BA
Radiol Clin North Am 1985 Mar;23(1):121-39. PMID: 2858113
Testicular carcinoma.
Paulson DF
Curr Probl Cancer 1982 May;6(11):1-44. doi: 10.1016/s0147-0272(82)80013-5. PMID: 6179719
Testicular tumors.
Markland C
Curr Probl Surg 1968 Sep:3-51. doi: 10.1016/s0011-3840(68)80001-2. PMID: 4386486

Therapy

A 20-Year-Old-Man With New Onset of Melena.
Yang XY, Bégin LR, Tamaz R
Gastroenterology 2022 Jan;162(1):e14-e15. Epub 2021 Jun 17 doi: 10.1053/j.gastro.2021.05.065. PMID: 34146570
Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature.
Razafimahefa J, Gosset C, Culine S, Mongiat-Artus P, Verine J
Clin Genitourin Cancer 2018 Apr;16(2):e349-e354. Epub 2017 Dec 27 doi: 10.1016/j.clgc.2017.12.010. PMID: 29395947
Testicular carcinoma.
Paulson DF
Curr Probl Cancer 1982 May;6(11):1-44. doi: 10.1016/s0147-0272(82)80013-5. PMID: 6179719
Cancer chemotherapy.
Einhorn LH
Am Fam Physician 1977 Mar;15(3):186-90. PMID: 265134
The present status of cancer chemotherapy.
Krakoff IH
Med Clin North Am 1971 May;55(3):683-701. doi: 10.1016/s0025-7125(16)32511-1. PMID: 4102661

Prognosis

Placental Site Trophoblastic Tumor in Nonseminomatous Mixed Germ Cell Tumors of the Testis: a Case Report and Review of the Literature.
Razafimahefa J, Gosset C, Culine S, Mongiat-Artus P, Verine J
Clin Genitourin Cancer 2018 Apr;16(2):e349-e354. Epub 2017 Dec 27 doi: 10.1016/j.clgc.2017.12.010. PMID: 29395947
Neurological picture. Metastatic choriocarcinoma.
Vivekananda U, Howard RS, Matar W, Phadke R
J Neurol Neurosurg Psychiatry 2011 Mar;82(3):347-8. Epub 2010 Sep 30 doi: 10.1136/jnnp.2010.220012. PMID: 20884676
Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221
Malignant testicular tumours.
Del Vecchio P, Tawil E, Béland G
Can Med Assoc J 1974 Jan 19;110(2):159-62. PMID: 4855670Free PMC Article

Clinical prediction guides

Hyperglycosylated hCG.
Cole LA
Placenta 2007 Oct;28(10):977-86. Epub 2007 Mar 7 doi: 10.1016/j.placenta.2007.01.011. PMID: 17346790
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396
Prognostic significance of a decline in serum human chorionic gonadotropin levels after initial chemotherapy for advanced germ-cell carcinoma.
Picozzi VJ Jr, Freiha FS, Hannigan JF Jr, Torti FM
Ann Intern Med 1984 Feb;100(2):183-6. doi: 10.7326/0003-4819-100-2-183. PMID: 6318631
Testicular carcinoma in Denmark 1976-1980. Stage and selected clinical parameters at presentation.
Schultz HP, Arends J, Barlebo H, Brincker H, Strøyer-Christoffersen I, Engelholm SA, Gammelgaard PA, Genster H, Hansen HH, Krag Jacobsen G
Acta Radiol Oncol 1984;23(4):249-53. doi: 10.3109/02841868409136020. PMID: 6093441
Bleomycin in testicular teratomas.
Brunner KW, Sonntag RW
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol 1975 Nov 25;84(3):291-7. doi: 10.1007/BF00312250. PMID: 53948

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